{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:VASMV4NNTPG24RDPYHHG6YZ6KR","short_pith_number":"pith:VASMV4NN","canonical_record":{"source":{"id":"2507.08688","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-07-11T15:38:19Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"e64624dc913ae8894d28fab8b8fd1655a9f67125cbb005e1851d15c588549508","abstract_canon_sha256":"a2e022b14dae3d8c09066fa2dbb14f57bd935e22996331cd293faa07c161f8c7"},"schema_version":"1.0"},"canonical_sha256":"a824caf1ad9bcdae446fc1ce6f633e5471acfc53501205a7038072b3a3e732c7","source":{"kind":"arxiv","id":"2507.08688","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2507.08688","created_at":"2026-07-05T11:35:44Z"},{"alias_kind":"arxiv_version","alias_value":"2507.08688v1","created_at":"2026-07-05T11:35:44Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2507.08688","created_at":"2026-07-05T11:35:44Z"},{"alias_kind":"pith_short_12","alias_value":"VASMV4NNTPG2","created_at":"2026-07-05T11:35:44Z"},{"alias_kind":"pith_short_16","alias_value":"VASMV4NNTPG24RDP","created_at":"2026-07-05T11:35:44Z"},{"alias_kind":"pith_short_8","alias_value":"VASMV4NN","created_at":"2026-07-05T11:35:44Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:VASMV4NNTPG24RDPYHHG6YZ6KR","target":"record","payload":{"canonical_record":{"source":{"id":"2507.08688","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-07-11T15:38:19Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"e64624dc913ae8894d28fab8b8fd1655a9f67125cbb005e1851d15c588549508","abstract_canon_sha256":"a2e022b14dae3d8c09066fa2dbb14f57bd935e22996331cd293faa07c161f8c7"},"schema_version":"1.0"},"canonical_sha256":"a824caf1ad9bcdae446fc1ce6f633e5471acfc53501205a7038072b3a3e732c7","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:35:44.924860Z","signature_b64":"wyN+J6wO2j+2/hMZJkxSTctLVpMyUkRe2D2LDsWCJ15ZbR9iUwuak3v0+5+O43wFwpBw5A74daPzPVm6I5VFAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a824caf1ad9bcdae446fc1ce6f633e5471acfc53501205a7038072b3a3e732c7","last_reissued_at":"2026-07-05T11:35:44.924366Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:35:44.924366Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2507.08688","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:35:44Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"vlzPrqYuW7h5344hCB2nmiKNu8232/PuDZiJPdIMBDID6RZFI2GMxjPAvM42jhxfm6fXcARELkOdAwfg++zECw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-22T15:47:13.768960Z"},"content_sha256":"f5d5f9fc0396f1fb066a6a93e01fa2611e39d40088f1a7581b94e6c040740e70","schema_version":"1.0","event_id":"sha256:f5d5f9fc0396f1fb066a6a93e01fa2611e39d40088f1a7581b94e6c040740e70"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:VASMV4NNTPG24RDPYHHG6YZ6KR","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Rapid MRI-Based Synthetic CT Simulations for Precise tFUS Targeting","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"physics.med-ph","authors_text":"Bolun Li, Hengyu Gao, Jiefu Zhang, Jing Jing, Li Wang, Shaodong Ding, Tao Liu, Yubo Fan, Zhiwu An, Zhongtao Hu, Ziyang Liu","submitted_at":"2025-07-11T15:38:19Z","abstract_excerpt":"Accurate targeting is critical for the effectiveness of transcranial focused ultrasound (tFUS) neuromodulation. While CT provides accurate skull acoustic properties, its ionizing radiation and poor soft tissue contrast limit clinical applicability. In contrast, MRI offers superior neuroanatomical visualization without radiation exposure but lacks skull property mapping. This study proposes a novel, fully CT free simulation framework that integrates MRI-derived synthetic CT (sCT) with efficient modeling techniques for rapid and precise tFUS targeting. We trained a deep-learning model to generat"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2507.08688","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2507.08688/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:35:44Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/lGoAv2jYHMsjrf7fx/EocfWuFHWxLLVmIa1MKvaVjw/VhWDb/hq1Q71iqmEeI1err3N+Z+kLHkr98+Ar8XcBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-22T15:47:13.769564Z"},"content_sha256":"bcc405bf8cb1dfd13314b0b2ad8ab425a945877fdfb4fdb268dd67cc6bf5e96b","schema_version":"1.0","event_id":"sha256:bcc405bf8cb1dfd13314b0b2ad8ab425a945877fdfb4fdb268dd67cc6bf5e96b"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/VASMV4NNTPG24RDPYHHG6YZ6KR/bundle.json","state_url":"https://pith.science/pith/VASMV4NNTPG24RDPYHHG6YZ6KR/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/VASMV4NNTPG24RDPYHHG6YZ6KR/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-22T15:47:13Z","links":{"resolver":"https://pith.science/pith/VASMV4NNTPG24RDPYHHG6YZ6KR","bundle":"https://pith.science/pith/VASMV4NNTPG24RDPYHHG6YZ6KR/bundle.json","state":"https://pith.science/pith/VASMV4NNTPG24RDPYHHG6YZ6KR/state.json","well_known_bundle":"https://pith.science/.well-known/pith/VASMV4NNTPG24RDPYHHG6YZ6KR/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:VASMV4NNTPG24RDPYHHG6YZ6KR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a2e022b14dae3d8c09066fa2dbb14f57bd935e22996331cd293faa07c161f8c7","cross_cats_sorted":["physics.bio-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-07-11T15:38:19Z","title_canon_sha256":"e64624dc913ae8894d28fab8b8fd1655a9f67125cbb005e1851d15c588549508"},"schema_version":"1.0","source":{"id":"2507.08688","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2507.08688","created_at":"2026-07-05T11:35:44Z"},{"alias_kind":"arxiv_version","alias_value":"2507.08688v1","created_at":"2026-07-05T11:35:44Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2507.08688","created_at":"2026-07-05T11:35:44Z"},{"alias_kind":"pith_short_12","alias_value":"VASMV4NNTPG2","created_at":"2026-07-05T11:35:44Z"},{"alias_kind":"pith_short_16","alias_value":"VASMV4NNTPG24RDP","created_at":"2026-07-05T11:35:44Z"},{"alias_kind":"pith_short_8","alias_value":"VASMV4NN","created_at":"2026-07-05T11:35:44Z"}],"graph_snapshots":[{"event_id":"sha256:bcc405bf8cb1dfd13314b0b2ad8ab425a945877fdfb4fdb268dd67cc6bf5e96b","target":"graph","created_at":"2026-07-05T11:35:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2507.08688/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Accurate targeting is critical for the effectiveness of transcranial focused ultrasound (tFUS) neuromodulation. While CT provides accurate skull acoustic properties, its ionizing radiation and poor soft tissue contrast limit clinical applicability. In contrast, MRI offers superior neuroanatomical visualization without radiation exposure but lacks skull property mapping. This study proposes a novel, fully CT free simulation framework that integrates MRI-derived synthetic CT (sCT) with efficient modeling techniques for rapid and precise tFUS targeting. We trained a deep-learning model to generat","authors_text":"Bolun Li, Hengyu Gao, Jiefu Zhang, Jing Jing, Li Wang, Shaodong Ding, Tao Liu, Yubo Fan, Zhiwu An, Zhongtao Hu, Ziyang Liu","cross_cats":["physics.bio-ph"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-07-11T15:38:19Z","title":"Rapid MRI-Based Synthetic CT Simulations for Precise tFUS Targeting"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2507.08688","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f5d5f9fc0396f1fb066a6a93e01fa2611e39d40088f1a7581b94e6c040740e70","target":"record","created_at":"2026-07-05T11:35:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a2e022b14dae3d8c09066fa2dbb14f57bd935e22996331cd293faa07c161f8c7","cross_cats_sorted":["physics.bio-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-07-11T15:38:19Z","title_canon_sha256":"e64624dc913ae8894d28fab8b8fd1655a9f67125cbb005e1851d15c588549508"},"schema_version":"1.0","source":{"id":"2507.08688","kind":"arxiv","version":1}},"canonical_sha256":"a824caf1ad9bcdae446fc1ce6f633e5471acfc53501205a7038072b3a3e732c7","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a824caf1ad9bcdae446fc1ce6f633e5471acfc53501205a7038072b3a3e732c7","first_computed_at":"2026-07-05T11:35:44.924366Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:35:44.924366Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"wyN+J6wO2j+2/hMZJkxSTctLVpMyUkRe2D2LDsWCJ15ZbR9iUwuak3v0+5+O43wFwpBw5A74daPzPVm6I5VFAg==","signature_status":"signed_v1","signed_at":"2026-07-05T11:35:44.924860Z","signed_message":"canonical_sha256_bytes"},"source_id":"2507.08688","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f5d5f9fc0396f1fb066a6a93e01fa2611e39d40088f1a7581b94e6c040740e70","sha256:bcc405bf8cb1dfd13314b0b2ad8ab425a945877fdfb4fdb268dd67cc6bf5e96b"],"state_sha256":"4d183f561708f3571faf08c8a17a8c07490f22a67769c9d7f2093b518523acb8"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"HgbP69F3Iz4+12tX6YtKIA6qHPjD58veX0lngzwdXY4e2pU9wxHYVJgGtg/fk6mtDlZzokDQuDpKpa0mQFywDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-22T15:47:13.774365Z","bundle_sha256":"0ee06193df9cf5ed8600c1555fd5deb577df98b56bea10c0c2c61cc649d29f31"}}