{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:VDVAZWTQWGVYAIPHQO2KEJUKQF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"4ce3ef216f4ed62e01fd0499f869750ef4efab7eb5d498e3c99f8427df45c65c","cross_cats_sorted":["q-bio.CB","q-bio.MN"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.GN","submitted_at":"2018-12-17T05:05:09Z","title_canon_sha256":"a630fffe05c43441aad122ddd4b0ef8614062deb882589f0e069cac8bbdb6618"},"schema_version":"1.0","source":{"id":"1812.06617","kind":"arxiv","version":4}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1812.06617","created_at":"2026-05-17T23:47:43Z"},{"alias_kind":"arxiv_version","alias_value":"1812.06617v4","created_at":"2026-05-17T23:47:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1812.06617","created_at":"2026-05-17T23:47:43Z"},{"alias_kind":"pith_short_12","alias_value":"VDVAZWTQWGVY","created_at":"2026-05-18T12:32:59Z"},{"alias_kind":"pith_short_16","alias_value":"VDVAZWTQWGVYAIPH","created_at":"2026-05-18T12:32:59Z"},{"alias_kind":"pith_short_8","alias_value":"VDVAZWTQ","created_at":"2026-05-18T12:32:59Z"}],"graph_snapshots":[{"event_id":"sha256:7359283ee8cb625faad73cb740b93254f1e7fcb81cf8d50102b7aa3f06435035","target":"graph","created_at":"2026-05-17T23:47:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in fetal astrocytes will augment their neuroprotective transcriptome profile, while the antagonistic stimulation of alpha7nAChR will achieve the opposite. Using an in vivo - in vitro model of developmental programming of neuroinflammation induced by lipopolysacchar","authors_text":"A. Desrochers, G. Fecteau, H.L. Liu, J. Schulkin, J.W. MacDonald, L.D. Durosier, M. C. Antonelli, M. Cao, M. Cortes, M. Dorschner, M.G. Frasch, M. Weaver, P. Burns, R.A. Bernier, T. K. Bammler","cross_cats":["q-bio.CB","q-bio.MN"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.GN","submitted_at":"2018-12-17T05:05:09Z","title":"Alpha7 nicotinic acetylcholine receptor signaling modulates ovine fetal brain astrocytes transcriptome in response to endotoxin"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1812.06617","kind":"arxiv","version":4},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:3e5739b854c9a8b56173dd1d9c7537a8cd0d612ca13b9f0061d1f65cbee5f432","target":"record","created_at":"2026-05-17T23:47:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"4ce3ef216f4ed62e01fd0499f869750ef4efab7eb5d498e3c99f8427df45c65c","cross_cats_sorted":["q-bio.CB","q-bio.MN"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.GN","submitted_at":"2018-12-17T05:05:09Z","title_canon_sha256":"a630fffe05c43441aad122ddd4b0ef8614062deb882589f0e069cac8bbdb6618"},"schema_version":"1.0","source":{"id":"1812.06617","kind":"arxiv","version":4}},"canonical_sha256":"a8ea0cda70b1ab8021e783b4a2268a8176322b4b4b7e8251271fec46e5d37887","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a8ea0cda70b1ab8021e783b4a2268a8176322b4b4b7e8251271fec46e5d37887","first_computed_at":"2026-05-17T23:47:43.973234Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:47:43.973234Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"3+xJvvkMdgNMWtqDiUJmojx775h6BbthMq7Dw1x45OXQGH6y0uBaSyb8TQnjVe73icfiDdPF2Nfu7TL/PMaFBA==","signature_status":"signed_v1","signed_at":"2026-05-17T23:47:43.973912Z","signed_message":"canonical_sha256_bytes"},"source_id":"1812.06617","source_kind":"arxiv","source_version":4}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:3e5739b854c9a8b56173dd1d9c7537a8cd0d612ca13b9f0061d1f65cbee5f432","sha256:7359283ee8cb625faad73cb740b93254f1e7fcb81cf8d50102b7aa3f06435035"],"state_sha256":"01ccc5fdf0d9e677d9f4b8bed20b7bf3dc41131cbc7c8b0b38292ed94466fc84"}