{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:VH5TZRQG4DMKFIHERUN33VYGTS","short_pith_number":"pith:VH5TZRQG","canonical_record":{"source":{"id":"1510.01195","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2015-10-05T15:50:28Z","cross_cats_sorted":[],"title_canon_sha256":"44f66951c6aaad029bbf74bc8be6fc44aba71322e2cf4aace67aa0c06ed2bc13","abstract_canon_sha256":"6c425561b26d995b9b736540f2e2c007388fd0a08a97c7c794b7fb10d041a160"},"schema_version":"1.0"},"canonical_sha256":"a9fb3cc606e0d8a2a0e48d1bbdd7069cb988543ab40f2afb12c820c2e7d0906e","source":{"kind":"arxiv","id":"1510.01195","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1510.01195","created_at":"2026-05-18T01:16:17Z"},{"alias_kind":"arxiv_version","alias_value":"1510.01195v1","created_at":"2026-05-18T01:16:17Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1510.01195","created_at":"2026-05-18T01:16:17Z"},{"alias_kind":"pith_short_12","alias_value":"VH5TZRQG4DMK","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_16","alias_value":"VH5TZRQG4DMKFIHE","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_8","alias_value":"VH5TZRQG","created_at":"2026-05-18T12:29:44Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:VH5TZRQG4DMKFIHERUN33VYGTS","target":"record","payload":{"canonical_record":{"source":{"id":"1510.01195","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2015-10-05T15:50:28Z","cross_cats_sorted":[],"title_canon_sha256":"44f66951c6aaad029bbf74bc8be6fc44aba71322e2cf4aace67aa0c06ed2bc13","abstract_canon_sha256":"6c425561b26d995b9b736540f2e2c007388fd0a08a97c7c794b7fb10d041a160"},"schema_version":"1.0"},"canonical_sha256":"a9fb3cc606e0d8a2a0e48d1bbdd7069cb988543ab40f2afb12c820c2e7d0906e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:16:17.709178Z","signature_b64":"btFEoelUUQa/7oSVpLyydd73sH0I2rF8pr6OavJb95PBD5TMuGEpiq4b78tHUoj2cNGnVBIZfgggBq0VguhbCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a9fb3cc606e0d8a2a0e48d1bbdd7069cb988543ab40f2afb12c820c2e7d0906e","last_reissued_at":"2026-05-18T01:16:17.708416Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:16:17.708416Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1510.01195","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:16:17Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"neCofqSx+iA4+Fo6RYm2SpJYXq6Ad9umsKHqF3B6+k7NdOT4cG/5yvNBGuNaz726Gtm77/JsSYxtnDwpglYSBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T06:47:21.942131Z"},"content_sha256":"b7db1940aba4639af741bd911aa3db80b5251f50901c8d0c9d8cdb82278ed7ed","schema_version":"1.0","event_id":"sha256:b7db1940aba4639af741bd911aa3db80b5251f50901c8d0c9d8cdb82278ed7ed"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:VH5TZRQG4DMKFIHERUN33VYGTS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Boris I. Shraiman, Colin A. Russell, Richard A. Neher, Rodney S. Daniels, Trevor Bedford","submitted_at":"2015-10-05T15:50:28Z","abstract_excerpt":"Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and re-infect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA) and amino acid substitutions at exposed epitope sites in HA mediate loss of recognition by antibodies. Here, we show that antigenic differences measured through serological assay data are well described by a sum of antigenic changes along the path connecting viruses in a phylogenetic tree. This mapping onto the tree allows prediction of antigenicity from HA seque"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1510.01195","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:16:17Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"c7qIfHpRHEFG2lDSGY6G//bnJxhGKRWfDRMKE6DGQgHd6HGVNhiCnwPiIrBNOkxUKyu1+K1YWm4FAiWEu2GwBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T06:47:21.942821Z"},"content_sha256":"c94d8b59eb7596ef99f18e0900396033cd40523d57a6a4493121cd15e84f74a3","schema_version":"1.0","event_id":"sha256:c94d8b59eb7596ef99f18e0900396033cd40523d57a6a4493121cd15e84f74a3"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/VH5TZRQG4DMKFIHERUN33VYGTS/bundle.json","state_url":"https://pith.science/pith/VH5TZRQG4DMKFIHERUN33VYGTS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/VH5TZRQG4DMKFIHERUN33VYGTS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-06T06:47:21Z","links":{"resolver":"https://pith.science/pith/VH5TZRQG4DMKFIHERUN33VYGTS","bundle":"https://pith.science/pith/VH5TZRQG4DMKFIHERUN33VYGTS/bundle.json","state":"https://pith.science/pith/VH5TZRQG4DMKFIHERUN33VYGTS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/VH5TZRQG4DMKFIHERUN33VYGTS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:VH5TZRQG4DMKFIHERUN33VYGTS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6c425561b26d995b9b736540f2e2c007388fd0a08a97c7c794b7fb10d041a160","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2015-10-05T15:50:28Z","title_canon_sha256":"44f66951c6aaad029bbf74bc8be6fc44aba71322e2cf4aace67aa0c06ed2bc13"},"schema_version":"1.0","source":{"id":"1510.01195","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1510.01195","created_at":"2026-05-18T01:16:17Z"},{"alias_kind":"arxiv_version","alias_value":"1510.01195v1","created_at":"2026-05-18T01:16:17Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1510.01195","created_at":"2026-05-18T01:16:17Z"},{"alias_kind":"pith_short_12","alias_value":"VH5TZRQG4DMK","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_16","alias_value":"VH5TZRQG4DMKFIHE","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_8","alias_value":"VH5TZRQG","created_at":"2026-05-18T12:29:44Z"}],"graph_snapshots":[{"event_id":"sha256:c94d8b59eb7596ef99f18e0900396033cd40523d57a6a4493121cd15e84f74a3","target":"graph","created_at":"2026-05-18T01:16:17Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and re-infect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA) and amino acid substitutions at exposed epitope sites in HA mediate loss of recognition by antibodies. Here, we show that antigenic differences measured through serological assay data are well described by a sum of antigenic changes along the path connecting viruses in a phylogenetic tree. This mapping onto the tree allows prediction of antigenicity from HA seque","authors_text":"Boris I. Shraiman, Colin A. Russell, Richard A. Neher, Rodney S. Daniels, Trevor Bedford","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2015-10-05T15:50:28Z","title":"Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1510.01195","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b7db1940aba4639af741bd911aa3db80b5251f50901c8d0c9d8cdb82278ed7ed","target":"record","created_at":"2026-05-18T01:16:17Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6c425561b26d995b9b736540f2e2c007388fd0a08a97c7c794b7fb10d041a160","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2015-10-05T15:50:28Z","title_canon_sha256":"44f66951c6aaad029bbf74bc8be6fc44aba71322e2cf4aace67aa0c06ed2bc13"},"schema_version":"1.0","source":{"id":"1510.01195","kind":"arxiv","version":1}},"canonical_sha256":"a9fb3cc606e0d8a2a0e48d1bbdd7069cb988543ab40f2afb12c820c2e7d0906e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a9fb3cc606e0d8a2a0e48d1bbdd7069cb988543ab40f2afb12c820c2e7d0906e","first_computed_at":"2026-05-18T01:16:17.708416Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:16:17.708416Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"btFEoelUUQa/7oSVpLyydd73sH0I2rF8pr6OavJb95PBD5TMuGEpiq4b78tHUoj2cNGnVBIZfgggBq0VguhbCw==","signature_status":"signed_v1","signed_at":"2026-05-18T01:16:17.709178Z","signed_message":"canonical_sha256_bytes"},"source_id":"1510.01195","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b7db1940aba4639af741bd911aa3db80b5251f50901c8d0c9d8cdb82278ed7ed","sha256:c94d8b59eb7596ef99f18e0900396033cd40523d57a6a4493121cd15e84f74a3"],"state_sha256":"7da4526c3f327c82ab91373a582fee5c244cbd8894cb149ccd506157754691ff"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"rMXs9tCLftVbD13GMe4eRwi9SvKNoUx/OZDItfN29mgSwO1a/FzLm6uKzY5zR1Xr9QZ5RMr9ZFfv4pc0uZNPDw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-06T06:47:21.946714Z","bundle_sha256":"bf8bedd34ca94dbdee5ecab04c72f2839096cc3717ef2dbb631941e80b437643"}}