{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2015:VI5XRES4JXPNLJYNV2A7ML6EMD","short_pith_number":"pith:VI5XRES4","schema_version":"1.0","canonical_sha256":"aa3b78925c4dded5a70dae81f62fc460cd5feca5f6a6caea0d4c75085c5784ae","source":{"kind":"arxiv","id":"1509.07990","version":1},"attestation_state":"computed","paper":{"title":"Cortical microtubule nucleation can organise the cytoskeleton of $Drosophila$ oocytes to define the anteroposterior axis","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cond-mat.soft","physics.bio-ph"],"primary_cat":"q-bio.SC","authors_text":"Daniel St. Johnston, H\\'el\\`ene Doerflinger, J\\\"orn Dunkel, Philipp Khuc Trong, Raymond E. Goldstein","submitted_at":"2015-09-26T15:07:23Z","abstract_excerpt":"Many cells contain non-centrosomal arrays of microtubules (MT), but the assembly, organisation and function of these arrays are poorly understood. We present the first theoretical model for the non-centrosomal MT cytoskeleton in $Drosophila$ oocytes, in which $bicoid$ and $oskar$ mRNAs become localised to establish the anterior-posterior body axis. Constrained by experimental measurements, the model shows that a simple gradient of cortical MT nucleation is sufficient to reproduce the observed MT distribution, cytoplasmic flow patterns and localisation of $oskar$ and naive $bicoid$ mRNAs. Our s"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1509.07990","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.SC","submitted_at":"2015-09-26T15:07:23Z","cross_cats_sorted":["cond-mat.soft","physics.bio-ph"],"title_canon_sha256":"3a9c58302ec560a448b16aa7f3d8bdae796207682cac6983f0eaf1ebae2b1a90","abstract_canon_sha256":"0bdb22416c8c6c69036e0f3a1c0c6eec7ca3f17ee99b0971ab090c3c8f214ef3"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:31:54.972335Z","signature_b64":"EaC+Xxu19u+Nf9x7IBzerRrY2tlYi+VzURbH0wG/S11iCl3nHO3lXZOTuZ1mALrPA88Qyso8NieeUyI5Tg4AAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"aa3b78925c4dded5a70dae81f62fc460cd5feca5f6a6caea0d4c75085c5784ae","last_reissued_at":"2026-05-18T01:31:54.971873Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:31:54.971873Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Cortical microtubule nucleation can organise the cytoskeleton of $Drosophila$ oocytes to define the anteroposterior axis","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cond-mat.soft","physics.bio-ph"],"primary_cat":"q-bio.SC","authors_text":"Daniel St. Johnston, H\\'el\\`ene Doerflinger, J\\\"orn Dunkel, Philipp Khuc Trong, Raymond E. Goldstein","submitted_at":"2015-09-26T15:07:23Z","abstract_excerpt":"Many cells contain non-centrosomal arrays of microtubules (MT), but the assembly, organisation and function of these arrays are poorly understood. We present the first theoretical model for the non-centrosomal MT cytoskeleton in $Drosophila$ oocytes, in which $bicoid$ and $oskar$ mRNAs become localised to establish the anterior-posterior body axis. Constrained by experimental measurements, the model shows that a simple gradient of cortical MT nucleation is sufficient to reproduce the observed MT distribution, cytoplasmic flow patterns and localisation of $oskar$ and naive $bicoid$ mRNAs. Our s"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1509.07990","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1509.07990","created_at":"2026-05-18T01:31:54.971937+00:00"},{"alias_kind":"arxiv_version","alias_value":"1509.07990v1","created_at":"2026-05-18T01:31:54.971937+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1509.07990","created_at":"2026-05-18T01:31:54.971937+00:00"},{"alias_kind":"pith_short_12","alias_value":"VI5XRES4JXPN","created_at":"2026-05-18T12:29:44.643036+00:00"},{"alias_kind":"pith_short_16","alias_value":"VI5XRES4JXPNLJYN","created_at":"2026-05-18T12:29:44.643036+00:00"},{"alias_kind":"pith_short_8","alias_value":"VI5XRES4","created_at":"2026-05-18T12:29:44.643036+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/VI5XRES4JXPNLJYNV2A7ML6EMD","json":"https://pith.science/pith/VI5XRES4JXPNLJYNV2A7ML6EMD.json","graph_json":"https://pith.science/api/pith-number/VI5XRES4JXPNLJYNV2A7ML6EMD/graph.json","events_json":"https://pith.science/api/pith-number/VI5XRES4JXPNLJYNV2A7ML6EMD/events.json","paper":"https://pith.science/paper/VI5XRES4"},"agent_actions":{"view_html":"https://pith.science/pith/VI5XRES4JXPNLJYNV2A7ML6EMD","download_json":"https://pith.science/pith/VI5XRES4JXPNLJYNV2A7ML6EMD.json","view_paper":"https://pith.science/paper/VI5XRES4","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1509.07990&json=true","fetch_graph":"https://pith.science/api/pith-number/VI5XRES4JXPNLJYNV2A7ML6EMD/graph.json","fetch_events":"https://pith.science/api/pith-number/VI5XRES4JXPNLJYNV2A7ML6EMD/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/VI5XRES4JXPNLJYNV2A7ML6EMD/action/timestamp_anchor","attest_storage":"https://pith.science/pith/VI5XRES4JXPNLJYNV2A7ML6EMD/action/storage_attestation","attest_author":"https://pith.science/pith/VI5XRES4JXPNLJYNV2A7ML6EMD/action/author_attestation","sign_citation":"https://pith.science/pith/VI5XRES4JXPNLJYNV2A7ML6EMD/action/citation_signature","submit_replication":"https://pith.science/pith/VI5XRES4JXPNLJYNV2A7ML6EMD/action/replication_record"}},"created_at":"2026-05-18T01:31:54.971937+00:00","updated_at":"2026-05-18T01:31:54.971937+00:00"}