{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:VI5XRES4JXPNLJYNV2A7ML6EMD","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0bdb22416c8c6c69036e0f3a1c0c6eec7ca3f17ee99b0971ab090c3c8f214ef3","cross_cats_sorted":["cond-mat.soft","physics.bio-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.SC","submitted_at":"2015-09-26T15:07:23Z","title_canon_sha256":"3a9c58302ec560a448b16aa7f3d8bdae796207682cac6983f0eaf1ebae2b1a90"},"schema_version":"1.0","source":{"id":"1509.07990","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1509.07990","created_at":"2026-05-18T01:31:54Z"},{"alias_kind":"arxiv_version","alias_value":"1509.07990v1","created_at":"2026-05-18T01:31:54Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1509.07990","created_at":"2026-05-18T01:31:54Z"},{"alias_kind":"pith_short_12","alias_value":"VI5XRES4JXPN","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_16","alias_value":"VI5XRES4JXPNLJYN","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_8","alias_value":"VI5XRES4","created_at":"2026-05-18T12:29:44Z"}],"graph_snapshots":[{"event_id":"sha256:fe2710de90d50b2dad8ff8b25f927af6be4e743efc22757e768a81d2022f13da","target":"graph","created_at":"2026-05-18T01:31:54Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Many cells contain non-centrosomal arrays of microtubules (MT), but the assembly, organisation and function of these arrays are poorly understood. We present the first theoretical model for the non-centrosomal MT cytoskeleton in $Drosophila$ oocytes, in which $bicoid$ and $oskar$ mRNAs become localised to establish the anterior-posterior body axis. Constrained by experimental measurements, the model shows that a simple gradient of cortical MT nucleation is sufficient to reproduce the observed MT distribution, cytoplasmic flow patterns and localisation of $oskar$ and naive $bicoid$ mRNAs. Our s","authors_text":"Daniel St. Johnston, H\\'el\\`ene Doerflinger, J\\\"orn Dunkel, Philipp Khuc Trong, Raymond E. Goldstein","cross_cats":["cond-mat.soft","physics.bio-ph"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.SC","submitted_at":"2015-09-26T15:07:23Z","title":"Cortical microtubule nucleation can organise the cytoskeleton of $Drosophila$ oocytes to define the anteroposterior axis"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1509.07990","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a5e791d5f327573cc2af04dc821d51c1ad8aae237dadb1e04cc76c108dd330db","target":"record","created_at":"2026-05-18T01:31:54Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0bdb22416c8c6c69036e0f3a1c0c6eec7ca3f17ee99b0971ab090c3c8f214ef3","cross_cats_sorted":["cond-mat.soft","physics.bio-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.SC","submitted_at":"2015-09-26T15:07:23Z","title_canon_sha256":"3a9c58302ec560a448b16aa7f3d8bdae796207682cac6983f0eaf1ebae2b1a90"},"schema_version":"1.0","source":{"id":"1509.07990","kind":"arxiv","version":1}},"canonical_sha256":"aa3b78925c4dded5a70dae81f62fc460cd5feca5f6a6caea0d4c75085c5784ae","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"aa3b78925c4dded5a70dae81f62fc460cd5feca5f6a6caea0d4c75085c5784ae","first_computed_at":"2026-05-18T01:31:54.971873Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:31:54.971873Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"EaC+Xxu19u+Nf9x7IBzerRrY2tlYi+VzURbH0wG/S11iCl3nHO3lXZOTuZ1mALrPA88Qyso8NieeUyI5Tg4AAA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:31:54.972335Z","signed_message":"canonical_sha256_bytes"},"source_id":"1509.07990","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a5e791d5f327573cc2af04dc821d51c1ad8aae237dadb1e04cc76c108dd330db","sha256:fe2710de90d50b2dad8ff8b25f927af6be4e743efc22757e768a81d2022f13da"],"state_sha256":"0b45be0e916a4d3282e1c3ad39d208263f78c21ec877241639dfb4dc040ad68d"}