{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2022:VJOU4PK62JXFUTYECUSGDU3HPR","short_pith_number":"pith:VJOU4PK6","canonical_record":{"source":{"id":"2211.07472","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2022-11-06T22:28:11Z","cross_cats_sorted":["eess.SP"],"title_canon_sha256":"767d28049a96780b82cfd8fa691d7d0b6456dcdb936e689766814fd8769e9e70","abstract_canon_sha256":"2c988d9f4b0b85f1440a3b95fd753f0e15fd85f90a7b11430425a2584e852aa5"},"schema_version":"1.0"},"canonical_sha256":"aa5d4e3d5ed26e5a4f04152461d3677c43b8c2d5a03991a13cbb79abe2f93ea5","source":{"kind":"arxiv","id":"2211.07472","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2211.07472","created_at":"2026-07-05T07:26:35Z"},{"alias_kind":"arxiv_version","alias_value":"2211.07472v1","created_at":"2026-07-05T07:26:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2211.07472","created_at":"2026-07-05T07:26:35Z"},{"alias_kind":"pith_short_12","alias_value":"VJOU4PK62JXF","created_at":"2026-07-05T07:26:35Z"},{"alias_kind":"pith_short_16","alias_value":"VJOU4PK62JXFUTYE","created_at":"2026-07-05T07:26:35Z"},{"alias_kind":"pith_short_8","alias_value":"VJOU4PK6","created_at":"2026-07-05T07:26:35Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2022:VJOU4PK62JXFUTYECUSGDU3HPR","target":"record","payload":{"canonical_record":{"source":{"id":"2211.07472","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2022-11-06T22:28:11Z","cross_cats_sorted":["eess.SP"],"title_canon_sha256":"767d28049a96780b82cfd8fa691d7d0b6456dcdb936e689766814fd8769e9e70","abstract_canon_sha256":"2c988d9f4b0b85f1440a3b95fd753f0e15fd85f90a7b11430425a2584e852aa5"},"schema_version":"1.0"},"canonical_sha256":"aa5d4e3d5ed26e5a4f04152461d3677c43b8c2d5a03991a13cbb79abe2f93ea5","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T07:26:35.753304Z","signature_b64":"6DcxjrWfdSH5phN1xcX2Kq+oOH8h27lbM3hNKgrXxEUtsHw+d74hARD0MSFjHpxm6Nfdq+yMnPlAOU0HFdpuBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"aa5d4e3d5ed26e5a4f04152461d3677c43b8c2d5a03991a13cbb79abe2f93ea5","last_reissued_at":"2026-07-05T07:26:35.752925Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T07:26:35.752925Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2211.07472","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:26:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"b1q3OZhhcH9vsjLuzXfC2ZPiorojTxzcPO0Av3fF7jSrcXziGIA1FHT3gRehrFusOD5+7+UX5vcrSQWlABIwDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-06T10:42:54.193562Z"},"content_sha256":"d6a8760e2d4300becea543e24139c90ad79b414a4090721e2115f4653423938e","schema_version":"1.0","event_id":"sha256:d6a8760e2d4300becea543e24139c90ad79b414a4090721e2115f4653423938e"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2022:VJOU4PK62JXFUTYECUSGDU3HPR","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A new method using machine learning to integrate ECG and gated SPECT MPI for Cardiac Resynchronization Therapy Decision Support on behalf of the VISION-CRT","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["eess.SP"],"primary_cat":"physics.med-ph","authors_text":"Amalia Peix, Claudio T Mesquita, Diana Paez, Erivelton Nascimento, Ernest V. Garcia, Fernando de A. Fernandes, Kristoffer Larsen, Qiuying Sha, Weihua Zhou, Zhuo He","submitted_at":"2022-11-06T22:28:11Z","abstract_excerpt":"Cardiac resynchronization therapy (CRT) has been established as an important therapy for heart failure. Mechanical dyssynchrony has the potential to predict responders to CRT. The aim of this study was to report the development and the validation of machine learning (ML) models which integrates ECG, gated SPECT MPI (GMPS) and clinical variables to predict patients' response to CRT. This analysis included 153 patients who met criteria for CRT from a prospective cohort study. The variables were used to modeling predictive methods for CRT. Patients were classified as responders for an increase of"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2211.07472","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2211.07472/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:26:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"O2Tyw2JXe57rUUHu46V2AQECS1+Cn+YBhRhKteuwe+6a+JUqd+9pKdRSPo4NOF/Dj/28C4KyEzTFQAA1ijxCBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-06T10:42:54.193947Z"},"content_sha256":"a31e53fb19e3cebe23778cb5796f9bc2f3478122859befeafd02823f80a15498","schema_version":"1.0","event_id":"sha256:a31e53fb19e3cebe23778cb5796f9bc2f3478122859befeafd02823f80a15498"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/VJOU4PK62JXFUTYECUSGDU3HPR/bundle.json","state_url":"https://pith.science/pith/VJOU4PK62JXFUTYECUSGDU3HPR/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/VJOU4PK62JXFUTYECUSGDU3HPR/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-06T10:42:54Z","links":{"resolver":"https://pith.science/pith/VJOU4PK62JXFUTYECUSGDU3HPR","bundle":"https://pith.science/pith/VJOU4PK62JXFUTYECUSGDU3HPR/bundle.json","state":"https://pith.science/pith/VJOU4PK62JXFUTYECUSGDU3HPR/state.json","well_known_bundle":"https://pith.science/.well-known/pith/VJOU4PK62JXFUTYECUSGDU3HPR/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:VJOU4PK62JXFUTYECUSGDU3HPR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"2c988d9f4b0b85f1440a3b95fd753f0e15fd85f90a7b11430425a2584e852aa5","cross_cats_sorted":["eess.SP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2022-11-06T22:28:11Z","title_canon_sha256":"767d28049a96780b82cfd8fa691d7d0b6456dcdb936e689766814fd8769e9e70"},"schema_version":"1.0","source":{"id":"2211.07472","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2211.07472","created_at":"2026-07-05T07:26:35Z"},{"alias_kind":"arxiv_version","alias_value":"2211.07472v1","created_at":"2026-07-05T07:26:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2211.07472","created_at":"2026-07-05T07:26:35Z"},{"alias_kind":"pith_short_12","alias_value":"VJOU4PK62JXF","created_at":"2026-07-05T07:26:35Z"},{"alias_kind":"pith_short_16","alias_value":"VJOU4PK62JXFUTYE","created_at":"2026-07-05T07:26:35Z"},{"alias_kind":"pith_short_8","alias_value":"VJOU4PK6","created_at":"2026-07-05T07:26:35Z"}],"graph_snapshots":[{"event_id":"sha256:a31e53fb19e3cebe23778cb5796f9bc2f3478122859befeafd02823f80a15498","target":"graph","created_at":"2026-07-05T07:26:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2211.07472/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Cardiac resynchronization therapy (CRT) has been established as an important therapy for heart failure. Mechanical dyssynchrony has the potential to predict responders to CRT. The aim of this study was to report the development and the validation of machine learning (ML) models which integrates ECG, gated SPECT MPI (GMPS) and clinical variables to predict patients' response to CRT. This analysis included 153 patients who met criteria for CRT from a prospective cohort study. The variables were used to modeling predictive methods for CRT. Patients were classified as responders for an increase of","authors_text":"Amalia Peix, Claudio T Mesquita, Diana Paez, Erivelton Nascimento, Ernest V. Garcia, Fernando de A. Fernandes, Kristoffer Larsen, Qiuying Sha, Weihua Zhou, Zhuo He","cross_cats":["eess.SP"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2022-11-06T22:28:11Z","title":"A new method using machine learning to integrate ECG and gated SPECT MPI for Cardiac Resynchronization Therapy Decision Support on behalf of the VISION-CRT"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2211.07472","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:d6a8760e2d4300becea543e24139c90ad79b414a4090721e2115f4653423938e","target":"record","created_at":"2026-07-05T07:26:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"2c988d9f4b0b85f1440a3b95fd753f0e15fd85f90a7b11430425a2584e852aa5","cross_cats_sorted":["eess.SP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2022-11-06T22:28:11Z","title_canon_sha256":"767d28049a96780b82cfd8fa691d7d0b6456dcdb936e689766814fd8769e9e70"},"schema_version":"1.0","source":{"id":"2211.07472","kind":"arxiv","version":1}},"canonical_sha256":"aa5d4e3d5ed26e5a4f04152461d3677c43b8c2d5a03991a13cbb79abe2f93ea5","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"aa5d4e3d5ed26e5a4f04152461d3677c43b8c2d5a03991a13cbb79abe2f93ea5","first_computed_at":"2026-07-05T07:26:35.752925Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T07:26:35.752925Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"6DcxjrWfdSH5phN1xcX2Kq+oOH8h27lbM3hNKgrXxEUtsHw+d74hARD0MSFjHpxm6Nfdq+yMnPlAOU0HFdpuBw==","signature_status":"signed_v1","signed_at":"2026-07-05T07:26:35.753304Z","signed_message":"canonical_sha256_bytes"},"source_id":"2211.07472","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:d6a8760e2d4300becea543e24139c90ad79b414a4090721e2115f4653423938e","sha256:a31e53fb19e3cebe23778cb5796f9bc2f3478122859befeafd02823f80a15498"],"state_sha256":"face16b91a1bd4f07e3dc228014dbe815aacf81b0b7e6ae9c55e0b93200ecb32"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"sm3tDGiG9Z0b9AWvq7dQfq6UBMUmIjqjEPvuwRw9MusG4GOtuZWNL+4oih6IfrZJeH6IaqvDChfwibPH9TwkCw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-06T10:42:54.196298Z","bundle_sha256":"012506b9fed4b70bf9dcdb88a2724c75d7ae7591c8f3f086a2073ce3c9fb367c"}}