{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2016:VJXVVHOROFP66FXJLZY36ZIYNB","short_pith_number":"pith:VJXVVHOR","schema_version":"1.0","canonical_sha256":"aa6f5a9dd1715fef16e95e71bf6518684ccfe1a43d9bb3d607fa72601f31bb6f","source":{"kind":"arxiv","id":"1612.07992","version":1},"attestation_state":"computed","paper":{"title":"Robustness of synthetic oscillators in growing and dividing cells","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.SC"],"primary_cat":"physics.bio-ph","authors_text":"David K Lubensky, Joris Paijmans, Pieter Rein ten Wolde","submitted_at":"2016-12-23T15:00:02Z","abstract_excerpt":"Synthetic biology sets out to implement new functions in cells, and to develop a deeper understanding of biological design principles. In 2000, Elowitz and Leibler showed that by rational design of the reaction network, and using existing biological components, they could create a network that exhibits periodic gene expression, dubbed the repressilator (Elowitz and Leibler, Nature, 2000). More recently, Stricker et al. presented another synthetic oscillator, called the dual-feedback oscillator (Stricker et al., 2008), which is more stable. How the stability of these oscillators is affected by "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1612.07992","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2016-12-23T15:00:02Z","cross_cats_sorted":["q-bio.SC"],"title_canon_sha256":"0c066603cdd69411fb1a41384429a71c6efc7da113cebd1bc8b58b2c34248719","abstract_canon_sha256":"ae4d50c0f6b4114123e4397741d5b7e36fd45b8ec4b20689fed2734a57441424"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:44:23.927257Z","signature_b64":"LI5PTP2xYFkeS4wzb9XA4rbWocnybMiAPSdH8vt1c+JFkjPVy/qSe5pmkrA8jH2do9FHjEBBYGFFlDlaT9dNDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"aa6f5a9dd1715fef16e95e71bf6518684ccfe1a43d9bb3d607fa72601f31bb6f","last_reissued_at":"2026-05-18T00:44:23.926788Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:44:23.926788Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Robustness of synthetic oscillators in growing and dividing cells","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.SC"],"primary_cat":"physics.bio-ph","authors_text":"David K Lubensky, Joris Paijmans, Pieter Rein ten Wolde","submitted_at":"2016-12-23T15:00:02Z","abstract_excerpt":"Synthetic biology sets out to implement new functions in cells, and to develop a deeper understanding of biological design principles. In 2000, Elowitz and Leibler showed that by rational design of the reaction network, and using existing biological components, they could create a network that exhibits periodic gene expression, dubbed the repressilator (Elowitz and Leibler, Nature, 2000). More recently, Stricker et al. presented another synthetic oscillator, called the dual-feedback oscillator (Stricker et al., 2008), which is more stable. How the stability of these oscillators is affected by "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1612.07992","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1612.07992","created_at":"2026-05-18T00:44:23.926856+00:00"},{"alias_kind":"arxiv_version","alias_value":"1612.07992v1","created_at":"2026-05-18T00:44:23.926856+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1612.07992","created_at":"2026-05-18T00:44:23.926856+00:00"},{"alias_kind":"pith_short_12","alias_value":"VJXVVHOROFP6","created_at":"2026-05-18T12:30:48.956258+00:00"},{"alias_kind":"pith_short_16","alias_value":"VJXVVHOROFP66FXJ","created_at":"2026-05-18T12:30:48.956258+00:00"},{"alias_kind":"pith_short_8","alias_value":"VJXVVHOR","created_at":"2026-05-18T12:30:48.956258+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/VJXVVHOROFP66FXJLZY36ZIYNB","json":"https://pith.science/pith/VJXVVHOROFP66FXJLZY36ZIYNB.json","graph_json":"https://pith.science/api/pith-number/VJXVVHOROFP66FXJLZY36ZIYNB/graph.json","events_json":"https://pith.science/api/pith-number/VJXVVHOROFP66FXJLZY36ZIYNB/events.json","paper":"https://pith.science/paper/VJXVVHOR"},"agent_actions":{"view_html":"https://pith.science/pith/VJXVVHOROFP66FXJLZY36ZIYNB","download_json":"https://pith.science/pith/VJXVVHOROFP66FXJLZY36ZIYNB.json","view_paper":"https://pith.science/paper/VJXVVHOR","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1612.07992&json=true","fetch_graph":"https://pith.science/api/pith-number/VJXVVHOROFP66FXJLZY36ZIYNB/graph.json","fetch_events":"https://pith.science/api/pith-number/VJXVVHOROFP66FXJLZY36ZIYNB/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/VJXVVHOROFP66FXJLZY36ZIYNB/action/timestamp_anchor","attest_storage":"https://pith.science/pith/VJXVVHOROFP66FXJLZY36ZIYNB/action/storage_attestation","attest_author":"https://pith.science/pith/VJXVVHOROFP66FXJLZY36ZIYNB/action/author_attestation","sign_citation":"https://pith.science/pith/VJXVVHOROFP66FXJLZY36ZIYNB/action/citation_signature","submit_replication":"https://pith.science/pith/VJXVVHOROFP66FXJLZY36ZIYNB/action/replication_record"}},"created_at":"2026-05-18T00:44:23.926856+00:00","updated_at":"2026-05-18T00:44:23.926856+00:00"}