{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:VQ7Q243HRDWQR3HPA7COZB35IL","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"bc4d349fefa3a9686e7a111a0441377d964329f556121288b000a2e011c33d6b","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.OC","submitted_at":"2021-11-08T21:53:16Z","title_canon_sha256":"fb6f534ae237d89fa4673ba6372520a6f1873e6f0214149f5d69a934253ccea3"},"schema_version":"1.0","source":{"id":"2111.04847","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2111.04847","created_at":"2026-07-05T04:06:00Z"},{"alias_kind":"arxiv_version","alias_value":"2111.04847v2","created_at":"2026-07-05T04:06:00Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2111.04847","created_at":"2026-07-05T04:06:00Z"},{"alias_kind":"pith_short_12","alias_value":"VQ7Q243HRDWQ","created_at":"2026-07-05T04:06:00Z"},{"alias_kind":"pith_short_16","alias_value":"VQ7Q243HRDWQR3HP","created_at":"2026-07-05T04:06:00Z"},{"alias_kind":"pith_short_8","alias_value":"VQ7Q243H","created_at":"2026-07-05T04:06:00Z"}],"graph_snapshots":[{"event_id":"sha256:fd36f7f05b5f95212979f1f23e57665f97398b6d76b93f52a11d6d20df8c5afc","target":"graph","created_at":"2026-07-05T04:06:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2111.04847/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Intensity-modulated radiation therapy (IMRT) allows for the design of customized, highly-conformal treatments for cancer patients. Creating IMRT treatment plans, however, is a mathematically complex process, which is often tackled in multiple, simpler stages. This sequential approach typically separates radiation dose requirements from mechanical deliverability considerations, which may result in suboptimal treatment quality. For patient health to be considered paramount, holistic models must address these plan elements concurrently, eliminating quality loss between stages. This combined direc","authors_text":"Danielle A. Ripsman, Houra Mahmoudzadeh, Thomas G. Purdie, Timothy C. Y. Chan","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.OC","submitted_at":"2021-11-08T21:53:16Z","title":"Robust Direct Aperture Optimization for Radiation Therapy Treatment Planning"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2111.04847","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:afa5ca5b12c14f65a9a8032e1ac9a8b35cde30129edfa2b531cde6754ad7fec3","target":"record","created_at":"2026-07-05T04:06:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"bc4d349fefa3a9686e7a111a0441377d964329f556121288b000a2e011c33d6b","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.OC","submitted_at":"2021-11-08T21:53:16Z","title_canon_sha256":"fb6f534ae237d89fa4673ba6372520a6f1873e6f0214149f5d69a934253ccea3"},"schema_version":"1.0","source":{"id":"2111.04847","kind":"arxiv","version":2}},"canonical_sha256":"ac3f0d736788ed08ecef07c4ec877d42e87a860fe6e42111cf906b1255a3cd9b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ac3f0d736788ed08ecef07c4ec877d42e87a860fe6e42111cf906b1255a3cd9b","first_computed_at":"2026-07-05T04:06:00.938394Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T04:06:00.938394Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"ceIAOD3loWjkY/stLoXA7VmLcyC4Y8vahSpk5Oe3n9ISiolGmQk26GN7iVOfLgA5lkFz699tIcYynzgpKl7CDQ==","signature_status":"signed_v1","signed_at":"2026-07-05T04:06:00.938818Z","signed_message":"canonical_sha256_bytes"},"source_id":"2111.04847","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:afa5ca5b12c14f65a9a8032e1ac9a8b35cde30129edfa2b531cde6754ad7fec3","sha256:fd36f7f05b5f95212979f1f23e57665f97398b6d76b93f52a11d6d20df8c5afc"],"state_sha256":"96e006404b7c6f3f5151b0a8fced086c814d82d758de7a33e64ac68b7dd9fc3f"}