{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2020:VQL6TXVJEX5LCQMUSO57EIWP4O","short_pith_number":"pith:VQL6TXVJ","canonical_record":{"source":{"id":"2003.14042","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2020-03-31T09:11:42Z","cross_cats_sorted":["cond-mat.stat-mech"],"title_canon_sha256":"46be4098f07f7409f20fe4d131c66900e0ce56857eabd571b66d452c85ccf22a","abstract_canon_sha256":"f31f741bac1dc9eedf9d63a8d1cfe3c87033a24c30e8e624c786f55df928db17"},"schema_version":"1.0"},"canonical_sha256":"ac17e9dea925fab1419493bbf222cfe3802cbaf875f4515bfe7736382e6b07d6","source":{"kind":"arxiv","id":"2003.14042","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2003.14042","created_at":"2026-07-05T04:00:00Z"},{"alias_kind":"arxiv_version","alias_value":"2003.14042v1","created_at":"2026-07-05T04:00:00Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2003.14042","created_at":"2026-07-05T04:00:00Z"},{"alias_kind":"pith_short_12","alias_value":"VQL6TXVJEX5L","created_at":"2026-07-05T04:00:00Z"},{"alias_kind":"pith_short_16","alias_value":"VQL6TXVJEX5LCQMU","created_at":"2026-07-05T04:00:00Z"},{"alias_kind":"pith_short_8","alias_value":"VQL6TXVJ","created_at":"2026-07-05T04:00:00Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2020:VQL6TXVJEX5LCQMUSO57EIWP4O","target":"record","payload":{"canonical_record":{"source":{"id":"2003.14042","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2020-03-31T09:11:42Z","cross_cats_sorted":["cond-mat.stat-mech"],"title_canon_sha256":"46be4098f07f7409f20fe4d131c66900e0ce56857eabd571b66d452c85ccf22a","abstract_canon_sha256":"f31f741bac1dc9eedf9d63a8d1cfe3c87033a24c30e8e624c786f55df928db17"},"schema_version":"1.0"},"canonical_sha256":"ac17e9dea925fab1419493bbf222cfe3802cbaf875f4515bfe7736382e6b07d6","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T04:00:00.767632Z","signature_b64":"u79U0CCGvjSXBw9q7pbn+yLEvsakSj0w90PuRhSsCjTtwElfi4tNL8XR/2ViSEZ/brE8757J00XR5aPfJ1FkCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ac17e9dea925fab1419493bbf222cfe3802cbaf875f4515bfe7736382e6b07d6","last_reissued_at":"2026-07-05T04:00:00.767214Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T04:00:00.767214Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2003.14042","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T04:00:00Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"f9VmUmBkUV/uyjJugTw5Oeu4VGL7Yu7xZCcdaoEuyGIP1CS5D82jWchtzW4Cx+9rZpvHZ+7wVekPPd2B1uZLCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-22T13:24:50.273534Z"},"content_sha256":"cf775ae96a0b586bcd8fde47147a2d0fa84bec8cb40eaa310b3c7363ac91188f","schema_version":"1.0","event_id":"sha256:cf775ae96a0b586bcd8fde47147a2d0fa84bec8cb40eaa310b3c7363ac91188f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2020:VQL6TXVJEX5LCQMUSO57EIWP4O","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Thermodynamic cost, speed, fluctuations, and error reduction of biological copy machines","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech"],"primary_cat":"physics.bio-ph","authors_text":"Changbong Hyeon, Yonghyun Song","submitted_at":"2020-03-31T09:11:42Z","abstract_excerpt":"Due to large fluctuations in cellular environments, transfer of information in biological processes without regulation is inherently error-prone. The mechanistic details of error-reducing mechanisms in biological copying processes have been a subject of active research; however, how error reduction of a process is balanced with its thermodynamic cost and dynamical properties remain largely unexplored. Here, we study the error reducing strategies in light of the recently discovered thermodynamic uncertainty relation (TUR) that sets a physical bound to the cost-precision trade-off relevant in ge"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2003.14042","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2003.14042/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T04:00:00Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"uWSvl/KiGSDt1FGSHNzGXSgY3zHk5N9PVixLuymMplAsDquDrZkZgVRzkzSA8ORO8E6PqDwnySRbemcLvmWMBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-22T13:24:50.274410Z"},"content_sha256":"abb42734cacb0f196a6a5b0283075c1654f76177d6fdfcc4ff0b3eee409586d7","schema_version":"1.0","event_id":"sha256:abb42734cacb0f196a6a5b0283075c1654f76177d6fdfcc4ff0b3eee409586d7"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/VQL6TXVJEX5LCQMUSO57EIWP4O/bundle.json","state_url":"https://pith.science/pith/VQL6TXVJEX5LCQMUSO57EIWP4O/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/VQL6TXVJEX5LCQMUSO57EIWP4O/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-22T13:24:50Z","links":{"resolver":"https://pith.science/pith/VQL6TXVJEX5LCQMUSO57EIWP4O","bundle":"https://pith.science/pith/VQL6TXVJEX5LCQMUSO57EIWP4O/bundle.json","state":"https://pith.science/pith/VQL6TXVJEX5LCQMUSO57EIWP4O/state.json","well_known_bundle":"https://pith.science/.well-known/pith/VQL6TXVJEX5LCQMUSO57EIWP4O/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2020:VQL6TXVJEX5LCQMUSO57EIWP4O","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f31f741bac1dc9eedf9d63a8d1cfe3c87033a24c30e8e624c786f55df928db17","cross_cats_sorted":["cond-mat.stat-mech"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2020-03-31T09:11:42Z","title_canon_sha256":"46be4098f07f7409f20fe4d131c66900e0ce56857eabd571b66d452c85ccf22a"},"schema_version":"1.0","source":{"id":"2003.14042","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2003.14042","created_at":"2026-07-05T04:00:00Z"},{"alias_kind":"arxiv_version","alias_value":"2003.14042v1","created_at":"2026-07-05T04:00:00Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2003.14042","created_at":"2026-07-05T04:00:00Z"},{"alias_kind":"pith_short_12","alias_value":"VQL6TXVJEX5L","created_at":"2026-07-05T04:00:00Z"},{"alias_kind":"pith_short_16","alias_value":"VQL6TXVJEX5LCQMU","created_at":"2026-07-05T04:00:00Z"},{"alias_kind":"pith_short_8","alias_value":"VQL6TXVJ","created_at":"2026-07-05T04:00:00Z"}],"graph_snapshots":[{"event_id":"sha256:abb42734cacb0f196a6a5b0283075c1654f76177d6fdfcc4ff0b3eee409586d7","target":"graph","created_at":"2026-07-05T04:00:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2003.14042/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Due to large fluctuations in cellular environments, transfer of information in biological processes without regulation is inherently error-prone. The mechanistic details of error-reducing mechanisms in biological copying processes have been a subject of active research; however, how error reduction of a process is balanced with its thermodynamic cost and dynamical properties remain largely unexplored. Here, we study the error reducing strategies in light of the recently discovered thermodynamic uncertainty relation (TUR) that sets a physical bound to the cost-precision trade-off relevant in ge","authors_text":"Changbong Hyeon, Yonghyun Song","cross_cats":["cond-mat.stat-mech"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2020-03-31T09:11:42Z","title":"Thermodynamic cost, speed, fluctuations, and error reduction of biological copy machines"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2003.14042","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:cf775ae96a0b586bcd8fde47147a2d0fa84bec8cb40eaa310b3c7363ac91188f","target":"record","created_at":"2026-07-05T04:00:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f31f741bac1dc9eedf9d63a8d1cfe3c87033a24c30e8e624c786f55df928db17","cross_cats_sorted":["cond-mat.stat-mech"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2020-03-31T09:11:42Z","title_canon_sha256":"46be4098f07f7409f20fe4d131c66900e0ce56857eabd571b66d452c85ccf22a"},"schema_version":"1.0","source":{"id":"2003.14042","kind":"arxiv","version":1}},"canonical_sha256":"ac17e9dea925fab1419493bbf222cfe3802cbaf875f4515bfe7736382e6b07d6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ac17e9dea925fab1419493bbf222cfe3802cbaf875f4515bfe7736382e6b07d6","first_computed_at":"2026-07-05T04:00:00.767214Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T04:00:00.767214Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"u79U0CCGvjSXBw9q7pbn+yLEvsakSj0w90PuRhSsCjTtwElfi4tNL8XR/2ViSEZ/brE8757J00XR5aPfJ1FkCw==","signature_status":"signed_v1","signed_at":"2026-07-05T04:00:00.767632Z","signed_message":"canonical_sha256_bytes"},"source_id":"2003.14042","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:cf775ae96a0b586bcd8fde47147a2d0fa84bec8cb40eaa310b3c7363ac91188f","sha256:abb42734cacb0f196a6a5b0283075c1654f76177d6fdfcc4ff0b3eee409586d7"],"state_sha256":"48bbc438bb05bf875e4c503c3da7e76c6e5e79550525a989c61152649803a61f"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"dncdjaeAU+l6Kw/hPIORgerG7p04D7GBmrQKHN9TbIqOBXhVSeiJre8DcccqUDNlX34kqST07mjobRN/7GhtDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-22T13:24:50.284863Z","bundle_sha256":"e78f538a5b5958ba491d9588bad1e3bc571a30ce33c470ea726ebc92423775ba"}}