{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:VRDB2VMF62PL7S4WA3UMODG3PS","short_pith_number":"pith:VRDB2VMF","canonical_record":{"source":{"id":"1805.05795","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2018-05-15T14:20:53Z","cross_cats_sorted":[],"title_canon_sha256":"c84876cc32d0f211573f4e81d18f8ccf63adfbccc899eac8718722d709ed37c4","abstract_canon_sha256":"6602320455237ccd1dd33a0f6c26a2687ea9468a9a61e0f1c55c31d781b4c22f"},"schema_version":"1.0"},"canonical_sha256":"ac461d5585f69ebfcb9606e8c70cdb7cb046dac16c928bfe543fcd64d76cf920","source":{"kind":"arxiv","id":"1805.05795","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1805.05795","created_at":"2026-05-18T00:15:53Z"},{"alias_kind":"arxiv_version","alias_value":"1805.05795v1","created_at":"2026-05-18T00:15:53Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1805.05795","created_at":"2026-05-18T00:15:53Z"},{"alias_kind":"pith_short_12","alias_value":"VRDB2VMF62PL","created_at":"2026-05-18T12:32:59Z"},{"alias_kind":"pith_short_16","alias_value":"VRDB2VMF62PL7S4W","created_at":"2026-05-18T12:32:59Z"},{"alias_kind":"pith_short_8","alias_value":"VRDB2VMF","created_at":"2026-05-18T12:32:59Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:VRDB2VMF62PL7S4WA3UMODG3PS","target":"record","payload":{"canonical_record":{"source":{"id":"1805.05795","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2018-05-15T14:20:53Z","cross_cats_sorted":[],"title_canon_sha256":"c84876cc32d0f211573f4e81d18f8ccf63adfbccc899eac8718722d709ed37c4","abstract_canon_sha256":"6602320455237ccd1dd33a0f6c26a2687ea9468a9a61e0f1c55c31d781b4c22f"},"schema_version":"1.0"},"canonical_sha256":"ac461d5585f69ebfcb9606e8c70cdb7cb046dac16c928bfe543fcd64d76cf920","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:15:53.661217Z","signature_b64":"1zbaKGxSuGoolFZQUfPimpZ/dvVkM0bheKAFWri/Gbj7L554kIoWpGYiI6zSaPNbMQ8MyvL9mlbQxs6D0eVlCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ac461d5585f69ebfcb9606e8c70cdb7cb046dac16c928bfe543fcd64d76cf920","last_reissued_at":"2026-05-18T00:15:53.660618Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:15:53.660618Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1805.05795","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:15:53Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"gvaPoz+lcgj1uBYXMACKd2CkHAiXfsfvrO3DFXazpIFpKif7sVQ/bvOf3dEajbuCK53BAMgNRi5qnRisONgMDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-01T03:18:03.612085Z"},"content_sha256":"d66b2c9f079784ed1d6dff722856cd14ca0f40258fe4c7860d27c7ff03ade017","schema_version":"1.0","event_id":"sha256:d66b2c9f079784ed1d6dff722856cd14ca0f40258fe4c7860d27c7ff03ade017"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:VRDB2VMF62PL7S4WA3UMODG3PS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Information-Anchored Sensitivity Analysis: Theory and Application","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"James R Carpenter, Michael G Kenward, Suzie Cro","submitted_at":"2018-05-15T14:20:53Z","abstract_excerpt":"Analysis of longitudinal randomised controlled trials is frequently complicated because patients deviate from the protocol. Where such deviations are relevant for the estimand, we are typically required to make an untestable assumption about post-deviation behaviour in order to perform our primary analysis and estimate the treatment effect. In such settings, it is now widely recognised that we should follow this with sensitivity analyses to explore the robustness of our inferences to alternative assumptions about post-deviation behaviour. Although there has been a lot of work on how to conduct"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1805.05795","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:15:53Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2pMtRZ8RsQNUr/Ti2bWBlOUClusGk1up52+PDiUVpKgnbo9iZq0Io2uAMnvbYVBoawf09rAUPaJt+lFVXrQWAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-01T03:18:03.612457Z"},"content_sha256":"b113bfddeafc465084db7944fdb7d7e7c1c359f7ef3ddcade42309e2133493c1","schema_version":"1.0","event_id":"sha256:b113bfddeafc465084db7944fdb7d7e7c1c359f7ef3ddcade42309e2133493c1"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/VRDB2VMF62PL7S4WA3UMODG3PS/bundle.json","state_url":"https://pith.science/pith/VRDB2VMF62PL7S4WA3UMODG3PS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/VRDB2VMF62PL7S4WA3UMODG3PS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-01T03:18:03Z","links":{"resolver":"https://pith.science/pith/VRDB2VMF62PL7S4WA3UMODG3PS","bundle":"https://pith.science/pith/VRDB2VMF62PL7S4WA3UMODG3PS/bundle.json","state":"https://pith.science/pith/VRDB2VMF62PL7S4WA3UMODG3PS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/VRDB2VMF62PL7S4WA3UMODG3PS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:VRDB2VMF62PL7S4WA3UMODG3PS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6602320455237ccd1dd33a0f6c26a2687ea9468a9a61e0f1c55c31d781b4c22f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2018-05-15T14:20:53Z","title_canon_sha256":"c84876cc32d0f211573f4e81d18f8ccf63adfbccc899eac8718722d709ed37c4"},"schema_version":"1.0","source":{"id":"1805.05795","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1805.05795","created_at":"2026-05-18T00:15:53Z"},{"alias_kind":"arxiv_version","alias_value":"1805.05795v1","created_at":"2026-05-18T00:15:53Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1805.05795","created_at":"2026-05-18T00:15:53Z"},{"alias_kind":"pith_short_12","alias_value":"VRDB2VMF62PL","created_at":"2026-05-18T12:32:59Z"},{"alias_kind":"pith_short_16","alias_value":"VRDB2VMF62PL7S4W","created_at":"2026-05-18T12:32:59Z"},{"alias_kind":"pith_short_8","alias_value":"VRDB2VMF","created_at":"2026-05-18T12:32:59Z"}],"graph_snapshots":[{"event_id":"sha256:b113bfddeafc465084db7944fdb7d7e7c1c359f7ef3ddcade42309e2133493c1","target":"graph","created_at":"2026-05-18T00:15:53Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Analysis of longitudinal randomised controlled trials is frequently complicated because patients deviate from the protocol. Where such deviations are relevant for the estimand, we are typically required to make an untestable assumption about post-deviation behaviour in order to perform our primary analysis and estimate the treatment effect. In such settings, it is now widely recognised that we should follow this with sensitivity analyses to explore the robustness of our inferences to alternative assumptions about post-deviation behaviour. Although there has been a lot of work on how to conduct","authors_text":"James R Carpenter, Michael G Kenward, Suzie Cro","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2018-05-15T14:20:53Z","title":"Information-Anchored Sensitivity Analysis: Theory and Application"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1805.05795","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:d66b2c9f079784ed1d6dff722856cd14ca0f40258fe4c7860d27c7ff03ade017","target":"record","created_at":"2026-05-18T00:15:53Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6602320455237ccd1dd33a0f6c26a2687ea9468a9a61e0f1c55c31d781b4c22f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2018-05-15T14:20:53Z","title_canon_sha256":"c84876cc32d0f211573f4e81d18f8ccf63adfbccc899eac8718722d709ed37c4"},"schema_version":"1.0","source":{"id":"1805.05795","kind":"arxiv","version":1}},"canonical_sha256":"ac461d5585f69ebfcb9606e8c70cdb7cb046dac16c928bfe543fcd64d76cf920","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ac461d5585f69ebfcb9606e8c70cdb7cb046dac16c928bfe543fcd64d76cf920","first_computed_at":"2026-05-18T00:15:53.660618Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:15:53.660618Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"1zbaKGxSuGoolFZQUfPimpZ/dvVkM0bheKAFWri/Gbj7L554kIoWpGYiI6zSaPNbMQ8MyvL9mlbQxs6D0eVlCA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:15:53.661217Z","signed_message":"canonical_sha256_bytes"},"source_id":"1805.05795","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:d66b2c9f079784ed1d6dff722856cd14ca0f40258fe4c7860d27c7ff03ade017","sha256:b113bfddeafc465084db7944fdb7d7e7c1c359f7ef3ddcade42309e2133493c1"],"state_sha256":"6a27ab17f794aa0699129989a79f66f43a730186fd4f46f2a7e9903656389d5f"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"x1CAP4BEDK0IbSv82mum4own51uCqKeP38V8FruBVCd6Af6KsrTNQBw3RsYD8Li4CIF12p/VICrRoeUkWUyjDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-01T03:18:03.614567Z","bundle_sha256":"1a376cd531675fee8808e6ccdf66961d8a4d2586983bc13d0229c88b993bfa0c"}}