{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2010:VRECSBUPJIYMNRLQMXDFTRIREL","short_pith_number":"pith:VRECSBUP","canonical_record":{"source":{"id":"1011.0200","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2010-10-31T20:02:06Z","cross_cats_sorted":["q-bio.PE","q-bio.QM"],"title_canon_sha256":"cb1cc2c4ac90d65448c91278693109afb2efc902df7965e61132a4d9b9e67dfb","abstract_canon_sha256":"7b8de50cea1f0295e1d297196949c0dc2b9a0180516c2129e6fe515d8e48c4c9"},"schema_version":"1.0"},"canonical_sha256":"ac4829068f4a30c6c57065c659c51122f19b3eb628baef1bf654713d01b86013","source":{"kind":"arxiv","id":"1011.0200","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1011.0200","created_at":"2026-05-18T04:37:30Z"},{"alias_kind":"arxiv_version","alias_value":"1011.0200v1","created_at":"2026-05-18T04:37:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1011.0200","created_at":"2026-05-18T04:37:30Z"},{"alias_kind":"pith_short_12","alias_value":"VRECSBUPJIYM","created_at":"2026-05-18T12:26:15Z"},{"alias_kind":"pith_short_16","alias_value":"VRECSBUPJIYMNRLQ","created_at":"2026-05-18T12:26:15Z"},{"alias_kind":"pith_short_8","alias_value":"VRECSBUP","created_at":"2026-05-18T12:26:15Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2010:VRECSBUPJIYMNRLQMXDFTRIREL","target":"record","payload":{"canonical_record":{"source":{"id":"1011.0200","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2010-10-31T20:02:06Z","cross_cats_sorted":["q-bio.PE","q-bio.QM"],"title_canon_sha256":"cb1cc2c4ac90d65448c91278693109afb2efc902df7965e61132a4d9b9e67dfb","abstract_canon_sha256":"7b8de50cea1f0295e1d297196949c0dc2b9a0180516c2129e6fe515d8e48c4c9"},"schema_version":"1.0"},"canonical_sha256":"ac4829068f4a30c6c57065c659c51122f19b3eb628baef1bf654713d01b86013","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:37:30.416240Z","signature_b64":"wXV2OdxKPTKSvXI8Bq9gEFoPcaEFXYQ5MVxyG7HTE/WbIYvraWUr50sb7gCsx46Km2ETTYHQZVBuElaBYGsPAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ac4829068f4a30c6c57065c659c51122f19b3eb628baef1bf654713d01b86013","last_reissued_at":"2026-05-18T04:37:30.415793Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:37:30.415793Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1011.0200","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:37:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"3NuUY3MXH5bzCWp+hRMU5uJwf48SuXI3lhsNfhYNNGAq4z0kdem1IQcYz/BH+fbtKhIHHTpt+nGdSGAHE4WGCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T12:12:34.233346Z"},"content_sha256":"096a02660d6c28a8e3958f0f292a01c42697f58345d42c2244244a68b8333c1d","schema_version":"1.0","event_id":"sha256:096a02660d6c28a8e3958f0f292a01c42697f58345d42c2244244a68b8333c1d"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2010:VRECSBUPJIYMNRLQMXDFTRIREL","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Limited Lifespan of Fragile Regions in Mammalian Evolution","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.PE","q-bio.QM"],"primary_cat":"q-bio.GN","authors_text":"Max A. Alekseyev, Pavel A. Pevzner","submitted_at":"2010-10-31T20:02:06Z","abstract_excerpt":"An important question in genome evolution is whether there exist fragile regions (rearrangement hotspots) where chromosomal rearrangements are happening over and over again. Although nearly all recent studies supported the existence of fragile regions in mammalian genomes, the most comprehensive phylogenomic study of mammals (Ma et al. (2006) Genome Research 16, 1557-1565) raised some doubts about their existence. We demonstrate that fragile regions are subject to a \"birth and death\" process, implying that fragility has limited evolutionary lifespan. This finding implies that fragile regions m"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1011.0200","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:37:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ydcQfFU3I3FqjOoeS9+IpfsFw35a1S+r5U30ib3qR9iDFXrIA+qZH/lTJZtuXq1v4fUQe3lyjNQpzeXRcD6TDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T12:12:34.233719Z"},"content_sha256":"38b49fe0029724160d7612535296f669ce93092187e03117773e583d6def2fd9","schema_version":"1.0","event_id":"sha256:38b49fe0029724160d7612535296f669ce93092187e03117773e583d6def2fd9"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/VRECSBUPJIYMNRLQMXDFTRIREL/bundle.json","state_url":"https://pith.science/pith/VRECSBUPJIYMNRLQMXDFTRIREL/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/VRECSBUPJIYMNRLQMXDFTRIREL/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-27T12:12:34Z","links":{"resolver":"https://pith.science/pith/VRECSBUPJIYMNRLQMXDFTRIREL","bundle":"https://pith.science/pith/VRECSBUPJIYMNRLQMXDFTRIREL/bundle.json","state":"https://pith.science/pith/VRECSBUPJIYMNRLQMXDFTRIREL/state.json","well_known_bundle":"https://pith.science/.well-known/pith/VRECSBUPJIYMNRLQMXDFTRIREL/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:VRECSBUPJIYMNRLQMXDFTRIREL","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"7b8de50cea1f0295e1d297196949c0dc2b9a0180516c2129e6fe515d8e48c4c9","cross_cats_sorted":["q-bio.PE","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2010-10-31T20:02:06Z","title_canon_sha256":"cb1cc2c4ac90d65448c91278693109afb2efc902df7965e61132a4d9b9e67dfb"},"schema_version":"1.0","source":{"id":"1011.0200","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1011.0200","created_at":"2026-05-18T04:37:30Z"},{"alias_kind":"arxiv_version","alias_value":"1011.0200v1","created_at":"2026-05-18T04:37:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1011.0200","created_at":"2026-05-18T04:37:30Z"},{"alias_kind":"pith_short_12","alias_value":"VRECSBUPJIYM","created_at":"2026-05-18T12:26:15Z"},{"alias_kind":"pith_short_16","alias_value":"VRECSBUPJIYMNRLQ","created_at":"2026-05-18T12:26:15Z"},{"alias_kind":"pith_short_8","alias_value":"VRECSBUP","created_at":"2026-05-18T12:26:15Z"}],"graph_snapshots":[{"event_id":"sha256:38b49fe0029724160d7612535296f669ce93092187e03117773e583d6def2fd9","target":"graph","created_at":"2026-05-18T04:37:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"An important question in genome evolution is whether there exist fragile regions (rearrangement hotspots) where chromosomal rearrangements are happening over and over again. Although nearly all recent studies supported the existence of fragile regions in mammalian genomes, the most comprehensive phylogenomic study of mammals (Ma et al. (2006) Genome Research 16, 1557-1565) raised some doubts about their existence. We demonstrate that fragile regions are subject to a \"birth and death\" process, implying that fragility has limited evolutionary lifespan. This finding implies that fragile regions m","authors_text":"Max A. Alekseyev, Pavel A. Pevzner","cross_cats":["q-bio.PE","q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2010-10-31T20:02:06Z","title":"Limited Lifespan of Fragile Regions in Mammalian Evolution"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1011.0200","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:096a02660d6c28a8e3958f0f292a01c42697f58345d42c2244244a68b8333c1d","target":"record","created_at":"2026-05-18T04:37:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"7b8de50cea1f0295e1d297196949c0dc2b9a0180516c2129e6fe515d8e48c4c9","cross_cats_sorted":["q-bio.PE","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2010-10-31T20:02:06Z","title_canon_sha256":"cb1cc2c4ac90d65448c91278693109afb2efc902df7965e61132a4d9b9e67dfb"},"schema_version":"1.0","source":{"id":"1011.0200","kind":"arxiv","version":1}},"canonical_sha256":"ac4829068f4a30c6c57065c659c51122f19b3eb628baef1bf654713d01b86013","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ac4829068f4a30c6c57065c659c51122f19b3eb628baef1bf654713d01b86013","first_computed_at":"2026-05-18T04:37:30.415793Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:37:30.415793Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"wXV2OdxKPTKSvXI8Bq9gEFoPcaEFXYQ5MVxyG7HTE/WbIYvraWUr50sb7gCsx46Km2ETTYHQZVBuElaBYGsPAQ==","signature_status":"signed_v1","signed_at":"2026-05-18T04:37:30.416240Z","signed_message":"canonical_sha256_bytes"},"source_id":"1011.0200","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:096a02660d6c28a8e3958f0f292a01c42697f58345d42c2244244a68b8333c1d","sha256:38b49fe0029724160d7612535296f669ce93092187e03117773e583d6def2fd9"],"state_sha256":"d650cb8900501baefba672f98fbaefbf1bc03dd8d55fc3d83851bd449af68450"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"7JMLbSMhuHXpM4WHr+rXNxJ+HBT4fpkCviafl2I4Lddyv6y+sBml1BoUOvzPd4/U2qDlleqJQ6Gc4V8Wx526Bw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-27T12:12:34.236292Z","bundle_sha256":"92d8240eb5e724aa5bb456c4d5feec43db87a96149c82b275f42cf4a923bff40"}}