{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:VT72TNYRIVHIRC73NITGAS2EUL","short_pith_number":"pith:VT72TNYR","canonical_record":{"source":{"id":"2603.23150","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"eess.SY","submitted_at":"2026-03-24T12:51:47Z","cross_cats_sorted":["cs.SY"],"title_canon_sha256":"d5bc4afbfdc6bfcf3bac893e8e25986eb964ff1292869693e2fae1e439233151","abstract_canon_sha256":"620a1ad286149bda3412a5ef1899a970de8f2a72f7ffb31bb83f4302b51d048a"},"schema_version":"1.0"},"canonical_sha256":"acffa9b711454e888bfb6a26604b44a2c33b40002a7da62ee9b64205c3246e31","source":{"kind":"arxiv","id":"2603.23150","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2603.23150","created_at":"2026-06-01T02:03:38Z"},{"alias_kind":"arxiv_version","alias_value":"2603.23150v2","created_at":"2026-06-01T02:03:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2603.23150","created_at":"2026-06-01T02:03:38Z"},{"alias_kind":"pith_short_12","alias_value":"VT72TNYRIVHI","created_at":"2026-06-01T02:03:38Z"},{"alias_kind":"pith_short_16","alias_value":"VT72TNYRIVHIRC73","created_at":"2026-06-01T02:03:38Z"},{"alias_kind":"pith_short_8","alias_value":"VT72TNYR","created_at":"2026-06-01T02:03:38Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:VT72TNYRIVHIRC73NITGAS2EUL","target":"record","payload":{"canonical_record":{"source":{"id":"2603.23150","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"eess.SY","submitted_at":"2026-03-24T12:51:47Z","cross_cats_sorted":["cs.SY"],"title_canon_sha256":"d5bc4afbfdc6bfcf3bac893e8e25986eb964ff1292869693e2fae1e439233151","abstract_canon_sha256":"620a1ad286149bda3412a5ef1899a970de8f2a72f7ffb31bb83f4302b51d048a"},"schema_version":"1.0"},"canonical_sha256":"acffa9b711454e888bfb6a26604b44a2c33b40002a7da62ee9b64205c3246e31","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-01T02:03:38.843867Z","signature_b64":"lJzU6rxME4a8y1i4k0GzEIpXvCkNxv9kQyaDkaJOSoxqBTv8fcOHfPy9DmRZYm9r1AH2ecgiHBpLs4xjsGUuCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"acffa9b711454e888bfb6a26604b44a2c33b40002a7da62ee9b64205c3246e31","last_reissued_at":"2026-06-01T02:03:38.842514Z","signature_status":"signed_v1","first_computed_at":"2026-06-01T02:03:38.842514Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2603.23150","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-01T02:03:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"pBcs4Qg3pn464TZq4eA21kkqhsaLJ7aGjhz8/8WhAWLw8aYpb5vG8yWWHAU3VFq1fgGO3h6B/q41W9VLls9uCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-21T17:31:35.044939Z"},"content_sha256":"4b0170aa31db7f43a242bba15dd5b43e734db79a40ae81bdd39368cfeb2503e3","schema_version":"1.0","event_id":"sha256:4b0170aa31db7f43a242bba15dd5b43e734db79a40ae81bdd39368cfeb2503e3"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:VT72TNYRIVHIRC73NITGAS2EUL","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Feedback Control of a Recirculating Bioreactor with Electrophoretic Removal of Inhibitory Extracellular DNA","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["cs.SY"],"primary_cat":"eess.SY","authors_text":"Antonio Spallone, Davide Fiore, Fabrizio Carten\\`i, Mario di Bernardo","submitted_at":"2026-03-24T12:51:47Z","abstract_excerpt":"Extracellular DNA accumulation in recirculating bioprocesses inhibits microbial growth and reduces productivity. We consider a continuous bioreactor with a recirculating loop and an electrophoretic filtration unit for selective DNA removal, and develop a feedback control framework combining online state and parameter estimation via an Unscented Kalman Filter with an adaptive Model Predictive Controller that jointly optimizes dilution rate and filtration activation. Closed-loop simulations under nominal and perturbed conditions show that the addition of the filtration unit enables the proposed "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2603.23150","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2603.23150/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-01T02:03:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"XddHNwTha4lhYn6ShcNXT2uzpj6ecjN55XkBdTXu2Xlcmpmx1rmgftxkf/Dmo/CwGtTDVu7mzacGiKUMlrMDBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-21T17:31:35.045343Z"},"content_sha256":"0ee262b64ef7f00dba4686c345f35310eb9d6e5053fe2995d594a4fbb988db03","schema_version":"1.0","event_id":"sha256:0ee262b64ef7f00dba4686c345f35310eb9d6e5053fe2995d594a4fbb988db03"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/VT72TNYRIVHIRC73NITGAS2EUL/bundle.json","state_url":"https://pith.science/pith/VT72TNYRIVHIRC73NITGAS2EUL/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/VT72TNYRIVHIRC73NITGAS2EUL/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-21T17:31:35Z","links":{"resolver":"https://pith.science/pith/VT72TNYRIVHIRC73NITGAS2EUL","bundle":"https://pith.science/pith/VT72TNYRIVHIRC73NITGAS2EUL/bundle.json","state":"https://pith.science/pith/VT72TNYRIVHIRC73NITGAS2EUL/state.json","well_known_bundle":"https://pith.science/.well-known/pith/VT72TNYRIVHIRC73NITGAS2EUL/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:VT72TNYRIVHIRC73NITGAS2EUL","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"620a1ad286149bda3412a5ef1899a970de8f2a72f7ffb31bb83f4302b51d048a","cross_cats_sorted":["cs.SY"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"eess.SY","submitted_at":"2026-03-24T12:51:47Z","title_canon_sha256":"d5bc4afbfdc6bfcf3bac893e8e25986eb964ff1292869693e2fae1e439233151"},"schema_version":"1.0","source":{"id":"2603.23150","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2603.23150","created_at":"2026-06-01T02:03:38Z"},{"alias_kind":"arxiv_version","alias_value":"2603.23150v2","created_at":"2026-06-01T02:03:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2603.23150","created_at":"2026-06-01T02:03:38Z"},{"alias_kind":"pith_short_12","alias_value":"VT72TNYRIVHI","created_at":"2026-06-01T02:03:38Z"},{"alias_kind":"pith_short_16","alias_value":"VT72TNYRIVHIRC73","created_at":"2026-06-01T02:03:38Z"},{"alias_kind":"pith_short_8","alias_value":"VT72TNYR","created_at":"2026-06-01T02:03:38Z"}],"graph_snapshots":[{"event_id":"sha256:0ee262b64ef7f00dba4686c345f35310eb9d6e5053fe2995d594a4fbb988db03","target":"graph","created_at":"2026-06-01T02:03:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2603.23150/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Extracellular DNA accumulation in recirculating bioprocesses inhibits microbial growth and reduces productivity. We consider a continuous bioreactor with a recirculating loop and an electrophoretic filtration unit for selective DNA removal, and develop a feedback control framework combining online state and parameter estimation via an Unscented Kalman Filter with an adaptive Model Predictive Controller that jointly optimizes dilution rate and filtration activation. Closed-loop simulations under nominal and perturbed conditions show that the addition of the filtration unit enables the proposed ","authors_text":"Antonio Spallone, Davide Fiore, Fabrizio Carten\\`i, Mario di Bernardo","cross_cats":["cs.SY"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"eess.SY","submitted_at":"2026-03-24T12:51:47Z","title":"Feedback Control of a Recirculating Bioreactor with Electrophoretic Removal of Inhibitory Extracellular DNA"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2603.23150","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:4b0170aa31db7f43a242bba15dd5b43e734db79a40ae81bdd39368cfeb2503e3","target":"record","created_at":"2026-06-01T02:03:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"620a1ad286149bda3412a5ef1899a970de8f2a72f7ffb31bb83f4302b51d048a","cross_cats_sorted":["cs.SY"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"eess.SY","submitted_at":"2026-03-24T12:51:47Z","title_canon_sha256":"d5bc4afbfdc6bfcf3bac893e8e25986eb964ff1292869693e2fae1e439233151"},"schema_version":"1.0","source":{"id":"2603.23150","kind":"arxiv","version":2}},"canonical_sha256":"acffa9b711454e888bfb6a26604b44a2c33b40002a7da62ee9b64205c3246e31","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"acffa9b711454e888bfb6a26604b44a2c33b40002a7da62ee9b64205c3246e31","first_computed_at":"2026-06-01T02:03:38.842514Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-01T02:03:38.842514Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"lJzU6rxME4a8y1i4k0GzEIpXvCkNxv9kQyaDkaJOSoxqBTv8fcOHfPy9DmRZYm9r1AH2ecgiHBpLs4xjsGUuCA==","signature_status":"signed_v1","signed_at":"2026-06-01T02:03:38.843867Z","signed_message":"canonical_sha256_bytes"},"source_id":"2603.23150","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:4b0170aa31db7f43a242bba15dd5b43e734db79a40ae81bdd39368cfeb2503e3","sha256:0ee262b64ef7f00dba4686c345f35310eb9d6e5053fe2995d594a4fbb988db03"],"state_sha256":"00d55c76dfd7b928e1e1b493426cfb9368d6dbb47997ef549f5f90c2bf05a2f2"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"iVhNXKSP/LxCECs18fOqpLzT360wTtZoN7Gi042sQVrIqYhfxrZzy7Xzc0w9Ql7YfAYl7ACr966o7rT8FQkNDw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-21T17:31:35.047496Z","bundle_sha256":"0feb74551348eeffb9970a947780eb5228d79c03576b9676313b616111ca9210"}}