{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:VTQOJ62SEN3PFYZ7ZCKJ2CX72B","short_pith_number":"pith:VTQOJ62S","canonical_record":{"source":{"id":"1605.03916","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2016-05-12T18:08:42Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"53320df1053203245330f338c8c1b7f0b52900fa09b8e4f356d0705b9d243f5f","abstract_canon_sha256":"3d0bcb48eced42443ed45624434ef9de29b170aded4f8f9db734fc0866ca0959"},"schema_version":"1.0"},"canonical_sha256":"ace0e4fb522376f2e33fc8949d0affd07bb3c4b3825b053c922efde8d59892eb","source":{"kind":"arxiv","id":"1605.03916","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1605.03916","created_at":"2026-05-18T01:01:35Z"},{"alias_kind":"arxiv_version","alias_value":"1605.03916v2","created_at":"2026-05-18T01:01:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1605.03916","created_at":"2026-05-18T01:01:35Z"},{"alias_kind":"pith_short_12","alias_value":"VTQOJ62SEN3P","created_at":"2026-05-18T12:30:48Z"},{"alias_kind":"pith_short_16","alias_value":"VTQOJ62SEN3PFYZ7","created_at":"2026-05-18T12:30:48Z"},{"alias_kind":"pith_short_8","alias_value":"VTQOJ62S","created_at":"2026-05-18T12:30:48Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:VTQOJ62SEN3PFYZ7ZCKJ2CX72B","target":"record","payload":{"canonical_record":{"source":{"id":"1605.03916","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2016-05-12T18:08:42Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"53320df1053203245330f338c8c1b7f0b52900fa09b8e4f356d0705b9d243f5f","abstract_canon_sha256":"3d0bcb48eced42443ed45624434ef9de29b170aded4f8f9db734fc0866ca0959"},"schema_version":"1.0"},"canonical_sha256":"ace0e4fb522376f2e33fc8949d0affd07bb3c4b3825b053c922efde8d59892eb","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:01:35.942081Z","signature_b64":"UfIxt0LBggpUApQqpr2/FkMEgEgcULRl20n7y5uyXjI0HehzHwuxhJ9wd89amxxFAkxHCsr1RP74G+7sQREyBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ace0e4fb522376f2e33fc8949d0affd07bb3c4b3825b053c922efde8d59892eb","last_reissued_at":"2026-05-18T01:01:35.941609Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:01:35.941609Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1605.03916","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:01:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"N1z0ngLuKbXn7CAXHxeYf/yEKSAbBi0yPht4lRU4LaU9CapUVdCeBNwGhyMvILiFgQVRoaUy//pWbDonmKiOAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-30T21:15:56.042888Z"},"content_sha256":"414d90f40da07306db540583069b82384bee42483ac7ef93547bb8b299f95cae","schema_version":"1.0","event_id":"sha256:414d90f40da07306db540583069b82384bee42483ac7ef93547bb8b299f95cae"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:VTQOJ62SEN3PFYZ7ZCKJ2CX72B","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Optimal inference strategies and their implications for the linear noise approximation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"cond-mat.stat-mech","authors_text":"David Hartich, Udo Seifert","submitted_at":"2016-05-12T18:08:42Z","abstract_excerpt":"We study the information loss of a class of inference strategies that is solely based on time averaging. For an array of independent binary sensors (e.g., receptors, single electron transistors) measuring a weak random signal (e.g., ligand concentration, gate voltage) this information loss is up to 0.5 bit per measurement irrespective of the number of sensors. We derive a condition related to the local detailed balance relation that determines whether or not such a loss of information occurs. Specifically, if the free energy difference arising from the signal is symmetrically distributed among"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1605.03916","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:01:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"hlHfOvS8SAWnAHucRsg+EORzeiaVvHBMDiGzi0/zk4xL8yPMipr7stLt/rFDB63YDKYglOOSchuxXVsLAerJCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-30T21:15:56.043531Z"},"content_sha256":"822ecd3360753ca006be95be908056bef74d560f20a95e13dec7729067ef3ec1","schema_version":"1.0","event_id":"sha256:822ecd3360753ca006be95be908056bef74d560f20a95e13dec7729067ef3ec1"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/VTQOJ62SEN3PFYZ7ZCKJ2CX72B/bundle.json","state_url":"https://pith.science/pith/VTQOJ62SEN3PFYZ7ZCKJ2CX72B/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/VTQOJ62SEN3PFYZ7ZCKJ2CX72B/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-30T21:15:56Z","links":{"resolver":"https://pith.science/pith/VTQOJ62SEN3PFYZ7ZCKJ2CX72B","bundle":"https://pith.science/pith/VTQOJ62SEN3PFYZ7ZCKJ2CX72B/bundle.json","state":"https://pith.science/pith/VTQOJ62SEN3PFYZ7ZCKJ2CX72B/state.json","well_known_bundle":"https://pith.science/.well-known/pith/VTQOJ62SEN3PFYZ7ZCKJ2CX72B/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:VTQOJ62SEN3PFYZ7ZCKJ2CX72B","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"3d0bcb48eced42443ed45624434ef9de29b170aded4f8f9db734fc0866ca0959","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2016-05-12T18:08:42Z","title_canon_sha256":"53320df1053203245330f338c8c1b7f0b52900fa09b8e4f356d0705b9d243f5f"},"schema_version":"1.0","source":{"id":"1605.03916","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1605.03916","created_at":"2026-05-18T01:01:35Z"},{"alias_kind":"arxiv_version","alias_value":"1605.03916v2","created_at":"2026-05-18T01:01:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1605.03916","created_at":"2026-05-18T01:01:35Z"},{"alias_kind":"pith_short_12","alias_value":"VTQOJ62SEN3P","created_at":"2026-05-18T12:30:48Z"},{"alias_kind":"pith_short_16","alias_value":"VTQOJ62SEN3PFYZ7","created_at":"2026-05-18T12:30:48Z"},{"alias_kind":"pith_short_8","alias_value":"VTQOJ62S","created_at":"2026-05-18T12:30:48Z"}],"graph_snapshots":[{"event_id":"sha256:822ecd3360753ca006be95be908056bef74d560f20a95e13dec7729067ef3ec1","target":"graph","created_at":"2026-05-18T01:01:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We study the information loss of a class of inference strategies that is solely based on time averaging. For an array of independent binary sensors (e.g., receptors, single electron transistors) measuring a weak random signal (e.g., ligand concentration, gate voltage) this information loss is up to 0.5 bit per measurement irrespective of the number of sensors. We derive a condition related to the local detailed balance relation that determines whether or not such a loss of information occurs. Specifically, if the free energy difference arising from the signal is symmetrically distributed among","authors_text":"David Hartich, Udo Seifert","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2016-05-12T18:08:42Z","title":"Optimal inference strategies and their implications for the linear noise approximation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1605.03916","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:414d90f40da07306db540583069b82384bee42483ac7ef93547bb8b299f95cae","target":"record","created_at":"2026-05-18T01:01:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"3d0bcb48eced42443ed45624434ef9de29b170aded4f8f9db734fc0866ca0959","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2016-05-12T18:08:42Z","title_canon_sha256":"53320df1053203245330f338c8c1b7f0b52900fa09b8e4f356d0705b9d243f5f"},"schema_version":"1.0","source":{"id":"1605.03916","kind":"arxiv","version":2}},"canonical_sha256":"ace0e4fb522376f2e33fc8949d0affd07bb3c4b3825b053c922efde8d59892eb","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ace0e4fb522376f2e33fc8949d0affd07bb3c4b3825b053c922efde8d59892eb","first_computed_at":"2026-05-18T01:01:35.941609Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:01:35.941609Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"UfIxt0LBggpUApQqpr2/FkMEgEgcULRl20n7y5uyXjI0HehzHwuxhJ9wd89amxxFAkxHCsr1RP74G+7sQREyBg==","signature_status":"signed_v1","signed_at":"2026-05-18T01:01:35.942081Z","signed_message":"canonical_sha256_bytes"},"source_id":"1605.03916","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:414d90f40da07306db540583069b82384bee42483ac7ef93547bb8b299f95cae","sha256:822ecd3360753ca006be95be908056bef74d560f20a95e13dec7729067ef3ec1"],"state_sha256":"d64e374ddfe3e7d6cfbb1d4f3875f26c2c72d8df1e3428c290b83c4454c61c38"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"rMCvtKdgVYcxxnvSyrLCUBAV6lcBbPJWh9ArtBGxwix6NE6uD3rmtMQeYKN86F1rUkgaLp+dnOWOZSphKFN0CQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-30T21:15:56.046557Z","bundle_sha256":"7a0495f34ff4bfc6f9016fe4657cb5c02f2b4c9cf4729d62e8b2a044f35fc1d3"}}