{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:VTRHCFZHD2JCNR42AFZMQ3VXLS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a23db658d2334c7a88b8880cba9b5595e9ebee89dfc79a391793e1bd045a1c3e","cross_cats_sorted":["math.DS","q-bio.TO"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.CB","submitted_at":"2024-11-18T23:26:35Z","title_canon_sha256":"15474d04ea0872c211dd93f7a4ac3be3dc62d62de7d28eb4d4c138435efeafb1"},"schema_version":"1.0","source":{"id":"2411.12123","kind":"arxiv","version":9}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2411.12123","created_at":"2026-05-20T00:04:05Z"},{"alias_kind":"arxiv_version","alias_value":"2411.12123v9","created_at":"2026-05-20T00:04:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2411.12123","created_at":"2026-05-20T00:04:05Z"},{"alias_kind":"pith_short_12","alias_value":"VTRHCFZHD2JC","created_at":"2026-05-20T00:04:05Z"},{"alias_kind":"pith_short_16","alias_value":"VTRHCFZHD2JCNR42","created_at":"2026-05-20T00:04:05Z"},{"alias_kind":"pith_short_8","alias_value":"VTRHCFZH","created_at":"2026-05-20T00:04:05Z"}],"graph_snapshots":[{"event_id":"sha256:482500fc32b7e5d3c87fd86350a6acbeac6e52e63cbde227236ed76f3cff0f5e","target":"graph","created_at":"2026-05-20T00:04:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2411.12123/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Colorectal cancer (CRC) poses a major public health challenge due to its increasing prevalence, particularly among younger populations. Microsatellite instability-high (MSI-H) CRC and deficient mismatch repair (dMMR) CRC constitute 15% of all CRC and exhibit remarkable responsiveness to immunotherapy, especially with PD-1 inhibitors. Despite this, there is a significant need to optimise immunotherapeutic regimens to maximise clinical efficacy and patient quality of life. To address this, we employ a novel framework driven by delay integro-differential equations to model the interactions among ","authors_text":"Georgio Hawi, Peter P. Lee, Peter S. Kim","cross_cats":["math.DS","q-bio.TO"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.CB","submitted_at":"2024-11-18T23:26:35Z","title":"Optimisation of neoadjuvant pembrolizumab therapy for locally advanced MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2411.12123","kind":"arxiv","version":9},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:fa623bb260f86f5880c3527af3b7d66fdb272212d1ef725cb5a6ac202bbc0eaf","target":"record","created_at":"2026-05-20T00:04:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a23db658d2334c7a88b8880cba9b5595e9ebee89dfc79a391793e1bd045a1c3e","cross_cats_sorted":["math.DS","q-bio.TO"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.CB","submitted_at":"2024-11-18T23:26:35Z","title_canon_sha256":"15474d04ea0872c211dd93f7a4ac3be3dc62d62de7d28eb4d4c138435efeafb1"},"schema_version":"1.0","source":{"id":"2411.12123","kind":"arxiv","version":9}},"canonical_sha256":"ace27117271e9226c79a0172c86eb75c9f3cc8470e0374cb9cef2d264bc2c0e6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ace27117271e9226c79a0172c86eb75c9f3cc8470e0374cb9cef2d264bc2c0e6","first_computed_at":"2026-05-20T00:04:05.819525Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-20T00:04:05.819525Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"8PpXayeiGUh37x13TAjc/JLeqwoDrc+JwdTtZB2sqD++eUCQdVodt75zo41fvwp6kmhwGW7MUgrU94sOYAuEDQ==","signature_status":"signed_v1","signed_at":"2026-05-20T00:04:05.820400Z","signed_message":"canonical_sha256_bytes"},"source_id":"2411.12123","source_kind":"arxiv","source_version":9}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:fa623bb260f86f5880c3527af3b7d66fdb272212d1ef725cb5a6ac202bbc0eaf","sha256:482500fc32b7e5d3c87fd86350a6acbeac6e52e63cbde227236ed76f3cff0f5e"],"state_sha256":"8411cd844d5d266ad8593167279c3153cf585ffb44c608f367a062674fc62f53"}