{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:VUB3OQ4NA4QA3X6TQRKMRIZVZV","short_pith_number":"pith:VUB3OQ4N","canonical_record":{"source":{"id":"1511.05599","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-11-17T22:00:25Z","cross_cats_sorted":[],"title_canon_sha256":"a3abadf57bddd4530458dc62f5431b5e91e6d022b99701d928d60df286f20a60","abstract_canon_sha256":"578b1d82b4b121f6f09dd386c822eb058693e8ab8a70f3c81c83f7f9317e28b8"},"schema_version":"1.0"},"canonical_sha256":"ad03b7438d07200ddfd38454c8a335cd5ce50d6cfb3bfaece074a5d40e760f33","source":{"kind":"arxiv","id":"1511.05599","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1511.05599","created_at":"2026-05-18T01:26:33Z"},{"alias_kind":"arxiv_version","alias_value":"1511.05599v1","created_at":"2026-05-18T01:26:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1511.05599","created_at":"2026-05-18T01:26:33Z"},{"alias_kind":"pith_short_12","alias_value":"VUB3OQ4NA4QA","created_at":"2026-05-18T12:29:47Z"},{"alias_kind":"pith_short_16","alias_value":"VUB3OQ4NA4QA3X6T","created_at":"2026-05-18T12:29:47Z"},{"alias_kind":"pith_short_8","alias_value":"VUB3OQ4N","created_at":"2026-05-18T12:29:47Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:VUB3OQ4NA4QA3X6TQRKMRIZVZV","target":"record","payload":{"canonical_record":{"source":{"id":"1511.05599","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-11-17T22:00:25Z","cross_cats_sorted":[],"title_canon_sha256":"a3abadf57bddd4530458dc62f5431b5e91e6d022b99701d928d60df286f20a60","abstract_canon_sha256":"578b1d82b4b121f6f09dd386c822eb058693e8ab8a70f3c81c83f7f9317e28b8"},"schema_version":"1.0"},"canonical_sha256":"ad03b7438d07200ddfd38454c8a335cd5ce50d6cfb3bfaece074a5d40e760f33","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:26:33.283977Z","signature_b64":"gdWo9B9j8++WpRjDhQKSlc62fgjFhqF0BZ0tpJfD52McUFs8eTWyA3mBNc7P83T8LMks/V0Qd34Hjn346YzZBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ad03b7438d07200ddfd38454c8a335cd5ce50d6cfb3bfaece074a5d40e760f33","last_reissued_at":"2026-05-18T01:26:33.283270Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:26:33.283270Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1511.05599","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:26:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"98FfQ0rIGYfKRp3/bGlu/+DeK8O6nG/omAE5j/5g7IhwdDVSgXGGJ3W7Q/k+WKCb3JESty4XvqJ94kabHe6TAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-08T18:36:55.853173Z"},"content_sha256":"b6d0123349382fcdfcea3e80bbf2e59d138a822057551b73bfa9033588ee2e70","schema_version":"1.0","event_id":"sha256:b6d0123349382fcdfcea3e80bbf2e59d138a822057551b73bfa9033588ee2e70"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:VUB3OQ4NA4QA3X6TQRKMRIZVZV","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Geometric analysis of pathways dynamics: application to versatility of TGF-{\\beta} receptors","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Andreas Weber, Aur\\'elien Naldi, Dima Grigoriev, Nathalie Th\\'eret, Ovidiu Radulescu, Satya Swarup Samal","submitted_at":"2015-11-17T22:00:25Z","abstract_excerpt":"We propose a new geometric approach to describe the qualitative dynamics of chemical reactions networks. By this method we identify metastable regimes, defined as low dimensional regions of the phase space close to which the dynamics is much slower compared to the rest of the phase space. Given the network topology and the orders of magnitude of kinetic parameters, the number of such metastable regimes is finite. The dynamics of the network can be described as a sequence of jumps from one metastable regime to another. We show that a geometrically computed connectivity graph restricts the set o"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1511.05599","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:26:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"K5podqXWsEKle8cvTG5plnlTkuEeq2cl+X3dhxqQ4cKrPMMlLfO5lDlE1Qy97N8yoBLr+s5Gq8H2efx4TDcsBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-08T18:36:55.853894Z"},"content_sha256":"d32add840deca99eea3f49f19c5ccc62b8999f1bc8f17db575263e8418bd19af","schema_version":"1.0","event_id":"sha256:d32add840deca99eea3f49f19c5ccc62b8999f1bc8f17db575263e8418bd19af"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/VUB3OQ4NA4QA3X6TQRKMRIZVZV/bundle.json","state_url":"https://pith.science/pith/VUB3OQ4NA4QA3X6TQRKMRIZVZV/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/VUB3OQ4NA4QA3X6TQRKMRIZVZV/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-08T18:36:55Z","links":{"resolver":"https://pith.science/pith/VUB3OQ4NA4QA3X6TQRKMRIZVZV","bundle":"https://pith.science/pith/VUB3OQ4NA4QA3X6TQRKMRIZVZV/bundle.json","state":"https://pith.science/pith/VUB3OQ4NA4QA3X6TQRKMRIZVZV/state.json","well_known_bundle":"https://pith.science/.well-known/pith/VUB3OQ4NA4QA3X6TQRKMRIZVZV/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:VUB3OQ4NA4QA3X6TQRKMRIZVZV","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"578b1d82b4b121f6f09dd386c822eb058693e8ab8a70f3c81c83f7f9317e28b8","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-11-17T22:00:25Z","title_canon_sha256":"a3abadf57bddd4530458dc62f5431b5e91e6d022b99701d928d60df286f20a60"},"schema_version":"1.0","source":{"id":"1511.05599","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1511.05599","created_at":"2026-05-18T01:26:33Z"},{"alias_kind":"arxiv_version","alias_value":"1511.05599v1","created_at":"2026-05-18T01:26:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1511.05599","created_at":"2026-05-18T01:26:33Z"},{"alias_kind":"pith_short_12","alias_value":"VUB3OQ4NA4QA","created_at":"2026-05-18T12:29:47Z"},{"alias_kind":"pith_short_16","alias_value":"VUB3OQ4NA4QA3X6T","created_at":"2026-05-18T12:29:47Z"},{"alias_kind":"pith_short_8","alias_value":"VUB3OQ4N","created_at":"2026-05-18T12:29:47Z"}],"graph_snapshots":[{"event_id":"sha256:d32add840deca99eea3f49f19c5ccc62b8999f1bc8f17db575263e8418bd19af","target":"graph","created_at":"2026-05-18T01:26:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We propose a new geometric approach to describe the qualitative dynamics of chemical reactions networks. By this method we identify metastable regimes, defined as low dimensional regions of the phase space close to which the dynamics is much slower compared to the rest of the phase space. Given the network topology and the orders of magnitude of kinetic parameters, the number of such metastable regimes is finite. The dynamics of the network can be described as a sequence of jumps from one metastable regime to another. We show that a geometrically computed connectivity graph restricts the set o","authors_text":"Andreas Weber, Aur\\'elien Naldi, Dima Grigoriev, Nathalie Th\\'eret, Ovidiu Radulescu, Satya Swarup Samal","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-11-17T22:00:25Z","title":"Geometric analysis of pathways dynamics: application to versatility of TGF-{\\beta} receptors"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1511.05599","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b6d0123349382fcdfcea3e80bbf2e59d138a822057551b73bfa9033588ee2e70","target":"record","created_at":"2026-05-18T01:26:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"578b1d82b4b121f6f09dd386c822eb058693e8ab8a70f3c81c83f7f9317e28b8","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-11-17T22:00:25Z","title_canon_sha256":"a3abadf57bddd4530458dc62f5431b5e91e6d022b99701d928d60df286f20a60"},"schema_version":"1.0","source":{"id":"1511.05599","kind":"arxiv","version":1}},"canonical_sha256":"ad03b7438d07200ddfd38454c8a335cd5ce50d6cfb3bfaece074a5d40e760f33","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ad03b7438d07200ddfd38454c8a335cd5ce50d6cfb3bfaece074a5d40e760f33","first_computed_at":"2026-05-18T01:26:33.283270Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:26:33.283270Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"gdWo9B9j8++WpRjDhQKSlc62fgjFhqF0BZ0tpJfD52McUFs8eTWyA3mBNc7P83T8LMks/V0Qd34Hjn346YzZBg==","signature_status":"signed_v1","signed_at":"2026-05-18T01:26:33.283977Z","signed_message":"canonical_sha256_bytes"},"source_id":"1511.05599","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b6d0123349382fcdfcea3e80bbf2e59d138a822057551b73bfa9033588ee2e70","sha256:d32add840deca99eea3f49f19c5ccc62b8999f1bc8f17db575263e8418bd19af"],"state_sha256":"eaeeeefa347c99d29d22aad91bf46af70ed29a67e0930e09038425352078e25f"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"FFT5AK5qcS+WWpRhwQGMtdQSb5V/Ku11tkfUd3dDwF4m4NDaTf2ukDpUukUV04J80uPeWiZTTPMGYWX8gHinBw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-08T18:36:55.857970Z","bundle_sha256":"c0476e5007e7900c61e099251b698548aae2f582ddf357c5a2a104dd75705a54"}}