{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:VUZEUN2JYKE5O2GQ4WWUIOBR6V","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"bf038f2fd858b714e7ede1d879995402833cff207691e61253fb878d5111122d","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2024-03-16T00:12:02Z","title_canon_sha256":"95d6e84709ce14adb0cede39e3302567ff86684927d4364b6c1a310b15a78bc6"},"schema_version":"1.0","source":{"id":"2403.10742","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2403.10742","created_at":"2026-07-05T07:57:05Z"},{"alias_kind":"arxiv_version","alias_value":"2403.10742v1","created_at":"2026-07-05T07:57:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2403.10742","created_at":"2026-07-05T07:57:05Z"},{"alias_kind":"pith_short_12","alias_value":"VUZEUN2JYKE5","created_at":"2026-07-05T07:57:05Z"},{"alias_kind":"pith_short_16","alias_value":"VUZEUN2JYKE5O2GQ","created_at":"2026-07-05T07:57:05Z"},{"alias_kind":"pith_short_8","alias_value":"VUZEUN2J","created_at":"2026-07-05T07:57:05Z"}],"graph_snapshots":[{"event_id":"sha256:b387892cee61499de0487d9a3d953a5fe44606ced8b9a8a61bf374e282101754","target":"graph","created_at":"2026-07-05T07:57:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2403.10742/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Delayed treatment effects on time-to-event outcomes have often been observed in randomized controlled studies of cancer immunotherapies. In the case of delayed onset of treatment effect, the conventional test/estimation approach using the log-rank test for between-group comparison and Cox's hazard ratio to estimate the magnitude of treatment effect is not optimal, because the log-rank test is not the most powerful option, and the interpretation of the resulting hazard ratio is not obvious. Recently, alternative test/estimation approaches were proposed to address both the power issue and the in","authors_text":"Hajime Uno, Kenneth L. Kehl, Lu Tian, Miki Horiguchi","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2024-03-16T00:12:02Z","title":"Assessing Delayed Treatment Benefits of Immunotherapy Using Long-Term Average Hazard: A Novel Test/Estimation Approach"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2403.10742","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b6ca65254c99aeccfa461cf9da87203544eae2daf8a62aa7f494eeed5479272a","target":"record","created_at":"2026-07-05T07:57:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"bf038f2fd858b714e7ede1d879995402833cff207691e61253fb878d5111122d","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2024-03-16T00:12:02Z","title_canon_sha256":"95d6e84709ce14adb0cede39e3302567ff86684927d4364b6c1a310b15a78bc6"},"schema_version":"1.0","source":{"id":"2403.10742","kind":"arxiv","version":1}},"canonical_sha256":"ad324a3749c289d768d0e5ad443831f54d58aa0953868c762ee4bfc3ec3f6bb0","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ad324a3749c289d768d0e5ad443831f54d58aa0953868c762ee4bfc3ec3f6bb0","first_computed_at":"2026-07-05T07:57:05.961767Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T07:57:05.961767Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"USH5x3xhyNmwgcDUVUp5oKpmzlN0nHezaBdUkVsnMkaSuhcENlZFEbSSc5CZw3/wRym34h3aC1IWFukfK6q/BA==","signature_status":"signed_v1","signed_at":"2026-07-05T07:57:05.962385Z","signed_message":"canonical_sha256_bytes"},"source_id":"2403.10742","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b6ca65254c99aeccfa461cf9da87203544eae2daf8a62aa7f494eeed5479272a","sha256:b387892cee61499de0487d9a3d953a5fe44606ced8b9a8a61bf374e282101754"],"state_sha256":"9cf7431f29bd592e4301cbd8eb8969b822cade831f4b05c5aeac9fb90857b5fe"}