{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:VXGXTAVE4K6JS673UB3GL7I36T","short_pith_number":"pith:VXGXTAVE","canonical_record":{"source":{"id":"2508.18058","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2025-08-25T14:18:43Z","cross_cats_sorted":[],"title_canon_sha256":"e28dd577ad88b9d23f977b6f1673e46d22a944868f9d04114b7899eb3093d44d","abstract_canon_sha256":"2cd500643233db6f62459eb74ae1014ee4d87065fae07d7c454c4e1b3246b1e8"},"schema_version":"1.0"},"canonical_sha256":"adcd7982a4e2bc997bfba07665fd1bf4e7dc739ccf46d1391eb1bdb456c2f4a8","source":{"kind":"arxiv","id":"2508.18058","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2508.18058","created_at":"2026-07-05T11:58:52Z"},{"alias_kind":"arxiv_version","alias_value":"2508.18058v1","created_at":"2026-07-05T11:58:52Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2508.18058","created_at":"2026-07-05T11:58:52Z"},{"alias_kind":"pith_short_12","alias_value":"VXGXTAVE4K6J","created_at":"2026-07-05T11:58:52Z"},{"alias_kind":"pith_short_16","alias_value":"VXGXTAVE4K6JS673","created_at":"2026-07-05T11:58:52Z"},{"alias_kind":"pith_short_8","alias_value":"VXGXTAVE","created_at":"2026-07-05T11:58:52Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:VXGXTAVE4K6JS673UB3GL7I36T","target":"record","payload":{"canonical_record":{"source":{"id":"2508.18058","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2025-08-25T14:18:43Z","cross_cats_sorted":[],"title_canon_sha256":"e28dd577ad88b9d23f977b6f1673e46d22a944868f9d04114b7899eb3093d44d","abstract_canon_sha256":"2cd500643233db6f62459eb74ae1014ee4d87065fae07d7c454c4e1b3246b1e8"},"schema_version":"1.0"},"canonical_sha256":"adcd7982a4e2bc997bfba07665fd1bf4e7dc739ccf46d1391eb1bdb456c2f4a8","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:58:52.875768Z","signature_b64":"0myCJmCetG22O9xRioGimB3c1BtCPJzjYp4PwGxFmoe0fUqurtP91qhu94X62tN/AkUmKOu7BzN687cU6+vCCg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"adcd7982a4e2bc997bfba07665fd1bf4e7dc739ccf46d1391eb1bdb456c2f4a8","last_reissued_at":"2026-07-05T11:58:52.875254Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:58:52.875254Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2508.18058","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:58:52Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TzsHBpme4FR0t8ZvaEzHu9JRpxJticwT5GDGX3dPJI34m5fFBqauqxs7Mh4LZ05GJgvnzwAeMrIWQcZZYMkzBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-17T22:23:27.589354Z"},"content_sha256":"a551993ea5383f8aea6706de6354884d1fbaad3af77dd1b70baa22985fca4101","schema_version":"1.0","event_id":"sha256:a551993ea5383f8aea6706de6354884d1fbaad3af77dd1b70baa22985fca4101"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:VXGXTAVE4K6JS673UB3GL7I36T","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Comprehensively stratifying MCIs into distinct risk subtypes based on brain imaging genetics fusion learning","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"Jin Zhang, Junwei Han, Lei Du, Muheng Shang","submitted_at":"2025-08-25T14:18:43Z","abstract_excerpt":"Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer's disease (AD) and thus enrolling MCI subjects to undergo clinical trials is worthwhile. However, MCI groups usually show significant diversity and heterogeneity in the pathology and symptom, which pose great challenge to accurately select appropriate subjects. This study aimed to stratify MCI subjects into distinct subgroups with substantial difference in the risk of transitioning to AD by fusing multimodal brain imaging genetic data. The integrated imaging genetics method comprised three modules, i.e., the whole-genome-orien"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.18058","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2508.18058/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:58:52Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"rxdiJOXZt4hU55gD6O21xizZyUtBxp7bTpZbg/CQCWPlF3JVS+8gan2bj1G4kGFQMrBn3v6wYdAxkLijldJ2Bw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-17T22:23:27.590331Z"},"content_sha256":"8468931b34bb0531afd5cebaf1912e16668a6c58b53694b4fd9de6a2b2ca7996","schema_version":"1.0","event_id":"sha256:8468931b34bb0531afd5cebaf1912e16668a6c58b53694b4fd9de6a2b2ca7996"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/VXGXTAVE4K6JS673UB3GL7I36T/bundle.json","state_url":"https://pith.science/pith/VXGXTAVE4K6JS673UB3GL7I36T/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/VXGXTAVE4K6JS673UB3GL7I36T/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-17T22:23:27Z","links":{"resolver":"https://pith.science/pith/VXGXTAVE4K6JS673UB3GL7I36T","bundle":"https://pith.science/pith/VXGXTAVE4K6JS673UB3GL7I36T/bundle.json","state":"https://pith.science/pith/VXGXTAVE4K6JS673UB3GL7I36T/state.json","well_known_bundle":"https://pith.science/.well-known/pith/VXGXTAVE4K6JS673UB3GL7I36T/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:VXGXTAVE4K6JS673UB3GL7I36T","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"2cd500643233db6f62459eb74ae1014ee4d87065fae07d7c454c4e1b3246b1e8","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2025-08-25T14:18:43Z","title_canon_sha256":"e28dd577ad88b9d23f977b6f1673e46d22a944868f9d04114b7899eb3093d44d"},"schema_version":"1.0","source":{"id":"2508.18058","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2508.18058","created_at":"2026-07-05T11:58:52Z"},{"alias_kind":"arxiv_version","alias_value":"2508.18058v1","created_at":"2026-07-05T11:58:52Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2508.18058","created_at":"2026-07-05T11:58:52Z"},{"alias_kind":"pith_short_12","alias_value":"VXGXTAVE4K6J","created_at":"2026-07-05T11:58:52Z"},{"alias_kind":"pith_short_16","alias_value":"VXGXTAVE4K6JS673","created_at":"2026-07-05T11:58:52Z"},{"alias_kind":"pith_short_8","alias_value":"VXGXTAVE","created_at":"2026-07-05T11:58:52Z"}],"graph_snapshots":[{"event_id":"sha256:8468931b34bb0531afd5cebaf1912e16668a6c58b53694b4fd9de6a2b2ca7996","target":"graph","created_at":"2026-07-05T11:58:52Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2508.18058/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer's disease (AD) and thus enrolling MCI subjects to undergo clinical trials is worthwhile. However, MCI groups usually show significant diversity and heterogeneity in the pathology and symptom, which pose great challenge to accurately select appropriate subjects. This study aimed to stratify MCI subjects into distinct subgroups with substantial difference in the risk of transitioning to AD by fusing multimodal brain imaging genetic data. The integrated imaging genetics method comprised three modules, i.e., the whole-genome-orien","authors_text":"Jin Zhang, Junwei Han, Lei Du, Muheng Shang","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2025-08-25T14:18:43Z","title":"Comprehensively stratifying MCIs into distinct risk subtypes based on brain imaging genetics fusion learning"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.18058","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a551993ea5383f8aea6706de6354884d1fbaad3af77dd1b70baa22985fca4101","target":"record","created_at":"2026-07-05T11:58:52Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"2cd500643233db6f62459eb74ae1014ee4d87065fae07d7c454c4e1b3246b1e8","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2025-08-25T14:18:43Z","title_canon_sha256":"e28dd577ad88b9d23f977b6f1673e46d22a944868f9d04114b7899eb3093d44d"},"schema_version":"1.0","source":{"id":"2508.18058","kind":"arxiv","version":1}},"canonical_sha256":"adcd7982a4e2bc997bfba07665fd1bf4e7dc739ccf46d1391eb1bdb456c2f4a8","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"adcd7982a4e2bc997bfba07665fd1bf4e7dc739ccf46d1391eb1bdb456c2f4a8","first_computed_at":"2026-07-05T11:58:52.875254Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:58:52.875254Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"0myCJmCetG22O9xRioGimB3c1BtCPJzjYp4PwGxFmoe0fUqurtP91qhu94X62tN/AkUmKOu7BzN687cU6+vCCg==","signature_status":"signed_v1","signed_at":"2026-07-05T11:58:52.875768Z","signed_message":"canonical_sha256_bytes"},"source_id":"2508.18058","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a551993ea5383f8aea6706de6354884d1fbaad3af77dd1b70baa22985fca4101","sha256:8468931b34bb0531afd5cebaf1912e16668a6c58b53694b4fd9de6a2b2ca7996"],"state_sha256":"0feffe010860008833ea17cf86d803db9334f90d043781b3ea88abbb8def8865"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"X+0/XU3JP6MoqU0RQ4eJhCe2ojgJz+6Nbmd6HJw5m/zmAVyBlogjXY3cRsG6TRGJYYoxbStYUYmIfDKQjgOlBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-17T22:23:27.599232Z","bundle_sha256":"272c58b581f50ecf83a07d9ed334a858257606f15f4dd44b5b9586da1ddbea85"}}