{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2022:W4GDENZEBGANKFFC7RMSADUN5T","short_pith_number":"pith:W4GDENZE","canonical_record":{"source":{"id":"2202.07171","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.GN","submitted_at":"2022-02-15T03:47:26Z","cross_cats_sorted":[],"title_canon_sha256":"cae0111aa3d017b11f2fe5c3041fe76eb03a8663ae8ce4594adf541b2556a051","abstract_canon_sha256":"b19c73ab62a355f20bc4c7f65564c076a7580eaf0fa43a473ac13afe128cce99"},"schema_version":"1.0"},"canonical_sha256":"b70c3237240980d514a2fc59200e8decdc4120b3bad93bce268bc1daf662bea7","source":{"kind":"arxiv","id":"2202.07171","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2202.07171","created_at":"2026-07-05T03:56:57Z"},{"alias_kind":"arxiv_version","alias_value":"2202.07171v1","created_at":"2026-07-05T03:56:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2202.07171","created_at":"2026-07-05T03:56:57Z"},{"alias_kind":"pith_short_12","alias_value":"W4GDENZEBGAN","created_at":"2026-07-05T03:56:57Z"},{"alias_kind":"pith_short_16","alias_value":"W4GDENZEBGANKFFC","created_at":"2026-07-05T03:56:57Z"},{"alias_kind":"pith_short_8","alias_value":"W4GDENZE","created_at":"2026-07-05T03:56:57Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2022:W4GDENZEBGANKFFC7RMSADUN5T","target":"record","payload":{"canonical_record":{"source":{"id":"2202.07171","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.GN","submitted_at":"2022-02-15T03:47:26Z","cross_cats_sorted":[],"title_canon_sha256":"cae0111aa3d017b11f2fe5c3041fe76eb03a8663ae8ce4594adf541b2556a051","abstract_canon_sha256":"b19c73ab62a355f20bc4c7f65564c076a7580eaf0fa43a473ac13afe128cce99"},"schema_version":"1.0"},"canonical_sha256":"b70c3237240980d514a2fc59200e8decdc4120b3bad93bce268bc1daf662bea7","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T03:56:57.238331Z","signature_b64":"piA5bTeAUfDSn3PthNzZI6W6s6/hfQe19BwE0uJ1dBL11IaaUQCAK4thoERh16E5RBCKO/Jcd4CYA7KC5yPGBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b70c3237240980d514a2fc59200e8decdc4120b3bad93bce268bc1daf662bea7","last_reissued_at":"2026-07-05T03:56:57.237970Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T03:56:57.237970Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2202.07171","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:56:57Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"J0cVwCJGszTnw/eHGfBSgjxvS+Ghg0BnyJLsBvtb0ra3PI5o9Ec4/6s8Fp6rL+x2Zosf5mVP1Hok9GWKaPWHBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-05T09:06:29.135157Z"},"content_sha256":"a372626724cd4b93c7bf4cdd9ceb0f9005470660be8b631565209f77bb193bd4","schema_version":"1.0","event_id":"sha256:a372626724cd4b93c7bf4cdd9ceb0f9005470660be8b631565209f77bb193bd4"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2022:W4GDENZEBGANKFFC7RMSADUN5T","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Investigating the genomic background of CRISPR-Cas genomes for CRISPR-based antimicrobials","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.GN","authors_text":"Hyunjin Shim","submitted_at":"2022-02-15T03:47:26Z","abstract_excerpt":"CRISPR-Cas systems are an adaptive immunity that protects prokaryotes against foreign genetic elements. Genetic templates acquired during past infection events enable DNA-interacting enzymes to recognize foreign DNA for destruction. Due to the programmability and specificity of these genetic templates, CRISPR-Cas systems are potential alternative antibiotics that can be engineered to self-target antimicrobial resistance genes on the chromosome or plasmid. However, several fundamental questions remain to repurpose these tools against drug-resistant bacteria. For endogenous CRISPR-Cas self-targe"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2202.07171","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2202.07171/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:56:57Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"IWZZzBWMEgd4RnrENQR6ZT7OKw1+avybxY6hq8dhdi8c7C+UgQ0HvsDgWzBFmlc6C8ojIgSgzevs7q83faLVCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-05T09:06:29.135532Z"},"content_sha256":"9d3b887e822df7ccfcd05fd025aed23d119e8995d172fab6276916eb90093588","schema_version":"1.0","event_id":"sha256:9d3b887e822df7ccfcd05fd025aed23d119e8995d172fab6276916eb90093588"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/W4GDENZEBGANKFFC7RMSADUN5T/bundle.json","state_url":"https://pith.science/pith/W4GDENZEBGANKFFC7RMSADUN5T/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/W4GDENZEBGANKFFC7RMSADUN5T/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-05T09:06:29Z","links":{"resolver":"https://pith.science/pith/W4GDENZEBGANKFFC7RMSADUN5T","bundle":"https://pith.science/pith/W4GDENZEBGANKFFC7RMSADUN5T/bundle.json","state":"https://pith.science/pith/W4GDENZEBGANKFFC7RMSADUN5T/state.json","well_known_bundle":"https://pith.science/.well-known/pith/W4GDENZEBGANKFFC7RMSADUN5T/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:W4GDENZEBGANKFFC7RMSADUN5T","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b19c73ab62a355f20bc4c7f65564c076a7580eaf0fa43a473ac13afe128cce99","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.GN","submitted_at":"2022-02-15T03:47:26Z","title_canon_sha256":"cae0111aa3d017b11f2fe5c3041fe76eb03a8663ae8ce4594adf541b2556a051"},"schema_version":"1.0","source":{"id":"2202.07171","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2202.07171","created_at":"2026-07-05T03:56:57Z"},{"alias_kind":"arxiv_version","alias_value":"2202.07171v1","created_at":"2026-07-05T03:56:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2202.07171","created_at":"2026-07-05T03:56:57Z"},{"alias_kind":"pith_short_12","alias_value":"W4GDENZEBGAN","created_at":"2026-07-05T03:56:57Z"},{"alias_kind":"pith_short_16","alias_value":"W4GDENZEBGANKFFC","created_at":"2026-07-05T03:56:57Z"},{"alias_kind":"pith_short_8","alias_value":"W4GDENZE","created_at":"2026-07-05T03:56:57Z"}],"graph_snapshots":[{"event_id":"sha256:9d3b887e822df7ccfcd05fd025aed23d119e8995d172fab6276916eb90093588","target":"graph","created_at":"2026-07-05T03:56:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2202.07171/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"CRISPR-Cas systems are an adaptive immunity that protects prokaryotes against foreign genetic elements. Genetic templates acquired during past infection events enable DNA-interacting enzymes to recognize foreign DNA for destruction. Due to the programmability and specificity of these genetic templates, CRISPR-Cas systems are potential alternative antibiotics that can be engineered to self-target antimicrobial resistance genes on the chromosome or plasmid. However, several fundamental questions remain to repurpose these tools against drug-resistant bacteria. For endogenous CRISPR-Cas self-targe","authors_text":"Hyunjin Shim","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.GN","submitted_at":"2022-02-15T03:47:26Z","title":"Investigating the genomic background of CRISPR-Cas genomes for CRISPR-based antimicrobials"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2202.07171","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a372626724cd4b93c7bf4cdd9ceb0f9005470660be8b631565209f77bb193bd4","target":"record","created_at":"2026-07-05T03:56:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b19c73ab62a355f20bc4c7f65564c076a7580eaf0fa43a473ac13afe128cce99","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.GN","submitted_at":"2022-02-15T03:47:26Z","title_canon_sha256":"cae0111aa3d017b11f2fe5c3041fe76eb03a8663ae8ce4594adf541b2556a051"},"schema_version":"1.0","source":{"id":"2202.07171","kind":"arxiv","version":1}},"canonical_sha256":"b70c3237240980d514a2fc59200e8decdc4120b3bad93bce268bc1daf662bea7","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b70c3237240980d514a2fc59200e8decdc4120b3bad93bce268bc1daf662bea7","first_computed_at":"2026-07-05T03:56:57.237970Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T03:56:57.237970Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"piA5bTeAUfDSn3PthNzZI6W6s6/hfQe19BwE0uJ1dBL11IaaUQCAK4thoERh16E5RBCKO/Jcd4CYA7KC5yPGBg==","signature_status":"signed_v1","signed_at":"2026-07-05T03:56:57.238331Z","signed_message":"canonical_sha256_bytes"},"source_id":"2202.07171","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a372626724cd4b93c7bf4cdd9ceb0f9005470660be8b631565209f77bb193bd4","sha256:9d3b887e822df7ccfcd05fd025aed23d119e8995d172fab6276916eb90093588"],"state_sha256":"c8e20aea1f25ea2fb0c3e0f0357b415d82d5b8715589df020ec7bba5d4ede8a1"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"eWeq51hvZX0XZp6XjH56ytNZKiRGdITJ5zb7BLmIAa6tnu0IP2xpKps/dae2TLGL6sc+iIqKNwEUgpoj4YZfDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-05T09:06:29.137429Z","bundle_sha256":"cf75407bf33c78f548ff480fc87c22d85dac88e85ee7503ee66f033c1d07513c"}}