{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:W57YWNRPOBILE3DQVTRDZMX5IJ","short_pith_number":"pith:W57YWNRP","canonical_record":{"source":{"id":"1410.5324","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2014-10-20T15:49:29Z","cross_cats_sorted":["physics.bio-ph","q-bio.BM","q-bio.MN"],"title_canon_sha256":"8488eff12ca1984e5b311b25b67dfc8fbfe3fbfba184bde6f8102cf6ba32c973","abstract_canon_sha256":"bcacf07cc28332561da78c2979975be68b7b093cc8bd9c916caed3d933ae17b6"},"schema_version":"1.0"},"canonical_sha256":"b77f8b362f7050b26c70ace23cb2fd4269a6c6ba6fddd6fcf2a3d9a11bc2686e","source":{"kind":"arxiv","id":"1410.5324","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1410.5324","created_at":"2026-05-18T01:13:38Z"},{"alias_kind":"arxiv_version","alias_value":"1410.5324v1","created_at":"2026-05-18T01:13:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1410.5324","created_at":"2026-05-18T01:13:38Z"},{"alias_kind":"pith_short_12","alias_value":"W57YWNRPOBIL","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_16","alias_value":"W57YWNRPOBILE3DQ","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_8","alias_value":"W57YWNRP","created_at":"2026-05-18T12:28:54Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:W57YWNRPOBILE3DQVTRDZMX5IJ","target":"record","payload":{"canonical_record":{"source":{"id":"1410.5324","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2014-10-20T15:49:29Z","cross_cats_sorted":["physics.bio-ph","q-bio.BM","q-bio.MN"],"title_canon_sha256":"8488eff12ca1984e5b311b25b67dfc8fbfe3fbfba184bde6f8102cf6ba32c973","abstract_canon_sha256":"bcacf07cc28332561da78c2979975be68b7b093cc8bd9c916caed3d933ae17b6"},"schema_version":"1.0"},"canonical_sha256":"b77f8b362f7050b26c70ace23cb2fd4269a6c6ba6fddd6fcf2a3d9a11bc2686e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:13:38.295199Z","signature_b64":"SwMSWP/gy21XQn9vfW8dFBqoXTtHw7RCam5EHlOk3omkAIvDauJ5PPlBtFkwoXweXONXg9BCCM0i8NAJVFlkDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b77f8b362f7050b26c70ace23cb2fd4269a6c6ba6fddd6fcf2a3d9a11bc2686e","last_reissued_at":"2026-05-18T01:13:38.294410Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:13:38.294410Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1410.5324","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:13:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"viNVGHPuSdJH2peQLHGKxaES5mAIjg3YPR4SY2SGBos3HPid6O9M5Bo3RF8LFHm+X1lhV15wNThhmMtWt1OVCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T16:11:49.289961Z"},"content_sha256":"d9d9836ce8f237c233256ad88fea9dbd26352233cb1708f09e906a1d88425f8c","schema_version":"1.0","event_id":"sha256:d9d9836ce8f237c233256ad88fea9dbd26352233cb1708f09e906a1d88425f8c"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:W57YWNRPOBILE3DQVTRDZMX5IJ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Single-molecule modeling of mRNA degradation by miRNA: Lessons from data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.BM","q-bio.MN"],"primary_cat":"q-bio.SC","authors_text":"Angelo Valleriani, Celine Sin, Davide Chiarugi","submitted_at":"2014-10-20T15:49:29Z","abstract_excerpt":"Recent experimental results on the effect of miRNA on the decay of its target mRNA have been analyzed against a previously hypothesized single molecule degradation pathway. According to that hypothesis, the silencing complex (miRISC) first interacts with its target mRNA and then recruits the protein complexes associated with NOT1 and PAN3 to trigger deadenylation (and subsequent degradation) of the target mRNA. Our analysis of the experimental decay patterns allowed us to refine the structure of the degradation pathways at the single molecule level. Surprisingly, we found that if the previousl"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1410.5324","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:13:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"1N0nXRZJhMry30FkDc/RmfjMSR4dfUqTRbuTi6sEjiY/cs1V8VZ5D+LRsalvlx7S2QEvSxlY5VpXL5Zwb8PRBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T16:11:49.290684Z"},"content_sha256":"f2689045be65b7b33de27b6a4ae52d61b1e495635fac351753c73225f62d8be8","schema_version":"1.0","event_id":"sha256:f2689045be65b7b33de27b6a4ae52d61b1e495635fac351753c73225f62d8be8"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/W57YWNRPOBILE3DQVTRDZMX5IJ/bundle.json","state_url":"https://pith.science/pith/W57YWNRPOBILE3DQVTRDZMX5IJ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/W57YWNRPOBILE3DQVTRDZMX5IJ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T16:11:49Z","links":{"resolver":"https://pith.science/pith/W57YWNRPOBILE3DQVTRDZMX5IJ","bundle":"https://pith.science/pith/W57YWNRPOBILE3DQVTRDZMX5IJ/bundle.json","state":"https://pith.science/pith/W57YWNRPOBILE3DQVTRDZMX5IJ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/W57YWNRPOBILE3DQVTRDZMX5IJ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:W57YWNRPOBILE3DQVTRDZMX5IJ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"bcacf07cc28332561da78c2979975be68b7b093cc8bd9c916caed3d933ae17b6","cross_cats_sorted":["physics.bio-ph","q-bio.BM","q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2014-10-20T15:49:29Z","title_canon_sha256":"8488eff12ca1984e5b311b25b67dfc8fbfe3fbfba184bde6f8102cf6ba32c973"},"schema_version":"1.0","source":{"id":"1410.5324","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1410.5324","created_at":"2026-05-18T01:13:38Z"},{"alias_kind":"arxiv_version","alias_value":"1410.5324v1","created_at":"2026-05-18T01:13:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1410.5324","created_at":"2026-05-18T01:13:38Z"},{"alias_kind":"pith_short_12","alias_value":"W57YWNRPOBIL","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_16","alias_value":"W57YWNRPOBILE3DQ","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_8","alias_value":"W57YWNRP","created_at":"2026-05-18T12:28:54Z"}],"graph_snapshots":[{"event_id":"sha256:f2689045be65b7b33de27b6a4ae52d61b1e495635fac351753c73225f62d8be8","target":"graph","created_at":"2026-05-18T01:13:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Recent experimental results on the effect of miRNA on the decay of its target mRNA have been analyzed against a previously hypothesized single molecule degradation pathway. According to that hypothesis, the silencing complex (miRISC) first interacts with its target mRNA and then recruits the protein complexes associated with NOT1 and PAN3 to trigger deadenylation (and subsequent degradation) of the target mRNA. Our analysis of the experimental decay patterns allowed us to refine the structure of the degradation pathways at the single molecule level. Surprisingly, we found that if the previousl","authors_text":"Angelo Valleriani, Celine Sin, Davide Chiarugi","cross_cats":["physics.bio-ph","q-bio.BM","q-bio.MN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2014-10-20T15:49:29Z","title":"Single-molecule modeling of mRNA degradation by miRNA: Lessons from data"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1410.5324","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:d9d9836ce8f237c233256ad88fea9dbd26352233cb1708f09e906a1d88425f8c","target":"record","created_at":"2026-05-18T01:13:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"bcacf07cc28332561da78c2979975be68b7b093cc8bd9c916caed3d933ae17b6","cross_cats_sorted":["physics.bio-ph","q-bio.BM","q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2014-10-20T15:49:29Z","title_canon_sha256":"8488eff12ca1984e5b311b25b67dfc8fbfe3fbfba184bde6f8102cf6ba32c973"},"schema_version":"1.0","source":{"id":"1410.5324","kind":"arxiv","version":1}},"canonical_sha256":"b77f8b362f7050b26c70ace23cb2fd4269a6c6ba6fddd6fcf2a3d9a11bc2686e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b77f8b362f7050b26c70ace23cb2fd4269a6c6ba6fddd6fcf2a3d9a11bc2686e","first_computed_at":"2026-05-18T01:13:38.294410Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:13:38.294410Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"SwMSWP/gy21XQn9vfW8dFBqoXTtHw7RCam5EHlOk3omkAIvDauJ5PPlBtFkwoXweXONXg9BCCM0i8NAJVFlkDA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:13:38.295199Z","signed_message":"canonical_sha256_bytes"},"source_id":"1410.5324","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:d9d9836ce8f237c233256ad88fea9dbd26352233cb1708f09e906a1d88425f8c","sha256:f2689045be65b7b33de27b6a4ae52d61b1e495635fac351753c73225f62d8be8"],"state_sha256":"ecbe2dc5d5830995dfd4eca89456c39413df39767b2137daee7e277f79d6ef56"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"bv3/xzYqAYob2ShEvLofY622ehbSriRRcJOcKtpeguON8O0QCjoR5YOb257eQQ2z4IWxgUsKTnD6FIg2FP2bAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T16:11:49.294865Z","bundle_sha256":"c879c60f297aa357118783163c341bb84f485ed1dd834b5e8e4abd73913d23f1"}}