{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:WFC6OJDXNF7LDHJQ74MQQLWCC3","short_pith_number":"pith:WFC6OJDX","canonical_record":{"source":{"id":"2405.04078","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2024-05-07T07:21:20Z","cross_cats_sorted":["cs.AI","q-bio.QM"],"title_canon_sha256":"bd119dd186a910f623764bad9bbb1354717cb97468e4b942c9ad7c46a8f18691","abstract_canon_sha256":"6273e18e584b98e73eaedd9f95b26e02957ca2b9f23a25328ca02a9b8ec7e9f9"},"schema_version":"1.0"},"canonical_sha256":"b145e72477697eb19d30ff19082ec216f9cdab3893142002bc8104901d3b526b","source":{"kind":"arxiv","id":"2405.04078","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2405.04078","created_at":"2026-07-05T08:16:31Z"},{"alias_kind":"arxiv_version","alias_value":"2405.04078v1","created_at":"2026-07-05T08:16:31Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2405.04078","created_at":"2026-07-05T08:16:31Z"},{"alias_kind":"pith_short_12","alias_value":"WFC6OJDXNF7L","created_at":"2026-07-05T08:16:31Z"},{"alias_kind":"pith_short_16","alias_value":"WFC6OJDXNF7LDHJQ","created_at":"2026-07-05T08:16:31Z"},{"alias_kind":"pith_short_8","alias_value":"WFC6OJDX","created_at":"2026-07-05T08:16:31Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:WFC6OJDXNF7LDHJQ74MQQLWCC3","target":"record","payload":{"canonical_record":{"source":{"id":"2405.04078","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2024-05-07T07:21:20Z","cross_cats_sorted":["cs.AI","q-bio.QM"],"title_canon_sha256":"bd119dd186a910f623764bad9bbb1354717cb97468e4b942c9ad7c46a8f18691","abstract_canon_sha256":"6273e18e584b98e73eaedd9f95b26e02957ca2b9f23a25328ca02a9b8ec7e9f9"},"schema_version":"1.0"},"canonical_sha256":"b145e72477697eb19d30ff19082ec216f9cdab3893142002bc8104901d3b526b","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T08:16:31.546149Z","signature_b64":"G2bS2GbnT6809GmVg2y3MwBzus2EjgN6PTnd91tywV/LxRCkG+ZIlHuwh7ZhKkZqDlLFq215R5hmbEozCbiyAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b145e72477697eb19d30ff19082ec216f9cdab3893142002bc8104901d3b526b","last_reissued_at":"2026-07-05T08:16:31.545729Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T08:16:31.545729Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2405.04078","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T08:16:31Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ZCeRmYXIzx8F820Y4BZoFUq2ScstQDqIxgSO1fTIMTf+x0Wz2OQtdIL1XX32o61IrE9LJKdEEc1klL3xb0PnAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-09T21:15:58.565351Z"},"content_sha256":"f285f98d9689630239a08161aab84ee826e01195d3cffe92a849cb00a3b62d1a","schema_version":"1.0","event_id":"sha256:f285f98d9689630239a08161aab84ee826e01195d3cffe92a849cb00a3b62d1a"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:WFC6OJDXNF7LDHJQ74MQQLWCC3","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"WISER: Weak supervISion and supErvised Representation learning to improve drug response prediction in cancer","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.AI","q-bio.QM"],"primary_cat":"cs.LG","authors_text":"Aishwarya Jayagopal, Kumar Shubham, Prathosh AP, Syed Mohammed Danish, Vaibhav Rajan","submitted_at":"2024-05-07T07:21:20Z","abstract_excerpt":"Cancer, a leading cause of death globally, occurs due to genomic changes and manifests heterogeneously across patients. To advance research on personalized treatment strategies, the effectiveness of various drugs on cells derived from cancers (`cell lines') is experimentally determined in laboratory settings. Nevertheless, variations in the distribution of genomic data and drug responses between cell lines and humans arise due to biological and environmental differences. Moreover, while genomic profiles of many cancer patients are readily available, the scarcity of corresponding drug response "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2405.04078","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2405.04078/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T08:16:31Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"AQHMy4EpF9tWK/4LH9OelB3f7DMfBt43Ejj0a7foDTo9BgSUQ6kdNSK6NQNrVfYbDE1CbqjCaWrDfhdoyAWYAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-09T21:15:58.565884Z"},"content_sha256":"76df4d3e238897619ef5fd1572ca38472c92fc4d3b4631f106ca8756520ee4cf","schema_version":"1.0","event_id":"sha256:76df4d3e238897619ef5fd1572ca38472c92fc4d3b4631f106ca8756520ee4cf"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/WFC6OJDXNF7LDHJQ74MQQLWCC3/bundle.json","state_url":"https://pith.science/pith/WFC6OJDXNF7LDHJQ74MQQLWCC3/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/WFC6OJDXNF7LDHJQ74MQQLWCC3/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-09T21:15:58Z","links":{"resolver":"https://pith.science/pith/WFC6OJDXNF7LDHJQ74MQQLWCC3","bundle":"https://pith.science/pith/WFC6OJDXNF7LDHJQ74MQQLWCC3/bundle.json","state":"https://pith.science/pith/WFC6OJDXNF7LDHJQ74MQQLWCC3/state.json","well_known_bundle":"https://pith.science/.well-known/pith/WFC6OJDXNF7LDHJQ74MQQLWCC3/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:WFC6OJDXNF7LDHJQ74MQQLWCC3","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6273e18e584b98e73eaedd9f95b26e02957ca2b9f23a25328ca02a9b8ec7e9f9","cross_cats_sorted":["cs.AI","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2024-05-07T07:21:20Z","title_canon_sha256":"bd119dd186a910f623764bad9bbb1354717cb97468e4b942c9ad7c46a8f18691"},"schema_version":"1.0","source":{"id":"2405.04078","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2405.04078","created_at":"2026-07-05T08:16:31Z"},{"alias_kind":"arxiv_version","alias_value":"2405.04078v1","created_at":"2026-07-05T08:16:31Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2405.04078","created_at":"2026-07-05T08:16:31Z"},{"alias_kind":"pith_short_12","alias_value":"WFC6OJDXNF7L","created_at":"2026-07-05T08:16:31Z"},{"alias_kind":"pith_short_16","alias_value":"WFC6OJDXNF7LDHJQ","created_at":"2026-07-05T08:16:31Z"},{"alias_kind":"pith_short_8","alias_value":"WFC6OJDX","created_at":"2026-07-05T08:16:31Z"}],"graph_snapshots":[{"event_id":"sha256:76df4d3e238897619ef5fd1572ca38472c92fc4d3b4631f106ca8756520ee4cf","target":"graph","created_at":"2026-07-05T08:16:31Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2405.04078/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Cancer, a leading cause of death globally, occurs due to genomic changes and manifests heterogeneously across patients. To advance research on personalized treatment strategies, the effectiveness of various drugs on cells derived from cancers (`cell lines') is experimentally determined in laboratory settings. Nevertheless, variations in the distribution of genomic data and drug responses between cell lines and humans arise due to biological and environmental differences. Moreover, while genomic profiles of many cancer patients are readily available, the scarcity of corresponding drug response ","authors_text":"Aishwarya Jayagopal, Kumar Shubham, Prathosh AP, Syed Mohammed Danish, Vaibhav Rajan","cross_cats":["cs.AI","q-bio.QM"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2024-05-07T07:21:20Z","title":"WISER: Weak supervISion and supErvised Representation learning to improve drug response prediction in cancer"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2405.04078","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f285f98d9689630239a08161aab84ee826e01195d3cffe92a849cb00a3b62d1a","target":"record","created_at":"2026-07-05T08:16:31Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6273e18e584b98e73eaedd9f95b26e02957ca2b9f23a25328ca02a9b8ec7e9f9","cross_cats_sorted":["cs.AI","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2024-05-07T07:21:20Z","title_canon_sha256":"bd119dd186a910f623764bad9bbb1354717cb97468e4b942c9ad7c46a8f18691"},"schema_version":"1.0","source":{"id":"2405.04078","kind":"arxiv","version":1}},"canonical_sha256":"b145e72477697eb19d30ff19082ec216f9cdab3893142002bc8104901d3b526b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b145e72477697eb19d30ff19082ec216f9cdab3893142002bc8104901d3b526b","first_computed_at":"2026-07-05T08:16:31.545729Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T08:16:31.545729Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"G2bS2GbnT6809GmVg2y3MwBzus2EjgN6PTnd91tywV/LxRCkG+ZIlHuwh7ZhKkZqDlLFq215R5hmbEozCbiyAg==","signature_status":"signed_v1","signed_at":"2026-07-05T08:16:31.546149Z","signed_message":"canonical_sha256_bytes"},"source_id":"2405.04078","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f285f98d9689630239a08161aab84ee826e01195d3cffe92a849cb00a3b62d1a","sha256:76df4d3e238897619ef5fd1572ca38472c92fc4d3b4631f106ca8756520ee4cf"],"state_sha256":"362794d7e26adb7989db26d83f408147335def08b89c7ef7e536cc7bde732a24"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"RHcyEqc5sPYyzBvU6DLl0DJx2ICJbGrUOcAiuEgnpvnTMhxFO5MpPRE2LVUng9krvG71Buo180hobUnCwo4nAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-09T21:15:58.569618Z","bundle_sha256":"b618078c1553ea91e6562385b022ecbf718bd38e4831fa67cfdb6bec455036a2"}}