{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:WL6ANLNUR5NEYE227N6ZDRT4VC","short_pith_number":"pith:WL6ANLNU","canonical_record":{"source":{"id":"1412.5562","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2014-12-16T05:12:53Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"cc61e9b9be43c9cb966343381d58713a7b41ed710ed2faa9d4b9ade70df371d8","abstract_canon_sha256":"dcbde80d512e59d27b727f90802b605815fb4e3706710c1dbeca11de7c6e51c8"},"schema_version":"1.0"},"canonical_sha256":"b2fc06adb48f5a4c135afb7d91c67ca88aa4bb43f74331da820c92b78b3cfb30","source":{"kind":"arxiv","id":"1412.5562","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1412.5562","created_at":"2026-05-18T02:31:02Z"},{"alias_kind":"arxiv_version","alias_value":"1412.5562v1","created_at":"2026-05-18T02:31:02Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1412.5562","created_at":"2026-05-18T02:31:02Z"},{"alias_kind":"pith_short_12","alias_value":"WL6ANLNUR5NE","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_16","alias_value":"WL6ANLNUR5NEYE22","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_8","alias_value":"WL6ANLNU","created_at":"2026-05-18T12:28:54Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:WL6ANLNUR5NEYE227N6ZDRT4VC","target":"record","payload":{"canonical_record":{"source":{"id":"1412.5562","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2014-12-16T05:12:53Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"cc61e9b9be43c9cb966343381d58713a7b41ed710ed2faa9d4b9ade70df371d8","abstract_canon_sha256":"dcbde80d512e59d27b727f90802b605815fb4e3706710c1dbeca11de7c6e51c8"},"schema_version":"1.0"},"canonical_sha256":"b2fc06adb48f5a4c135afb7d91c67ca88aa4bb43f74331da820c92b78b3cfb30","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:31:02.744633Z","signature_b64":"QX7Lr0sE5W9WYPwg4kXfANSTIEkCEqMeLIFWnZ+6Ql9JkNy87iyQorEiadJTBooxyOJrQknJ1tJMgMq5Pi5tBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b2fc06adb48f5a4c135afb7d91c67ca88aa4bb43f74331da820c92b78b3cfb30","last_reissued_at":"2026-05-18T02:31:02.744181Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:31:02.744181Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1412.5562","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:31:02Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+KWNFfZW8oCjrJ02sAproa7UKFeTIVuTk/pc026aKHwU+cZqZgrXd66GXZZ4EG8Or6AIqT7xeipuzb9i/R4BAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T19:51:40.563515Z"},"content_sha256":"f3deae0246d658bf099d8934c0bfebc1458b71fbcf728a50c850e8482e0f1b27","schema_version":"1.0","event_id":"sha256:f3deae0246d658bf099d8934c0bfebc1458b71fbcf728a50c850e8482e0f1b27"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:WL6ANLNUR5NEYE227N6ZDRT4VC","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Correlations between Chondroitin Sulfate Physicochemical Properties and its in-vitro Absorption and Anti-inflammatory Activity","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.TO","authors_text":"Ashby B. Bodine, George Huang, James Brooks, Lahari Surapaneni, Ramakrishna Podila, Vivian Haley-Zitlin","submitted_at":"2014-12-16T05:12:53Z","abstract_excerpt":"Here, we investigated the influence of physicochemical characteristics of chondroitin sulfate (CS) on its in vitro absorption and anti-inflammatory activity. We used eight different synthetic and natural CS samples with a range of molecular weights (7-35 kDa) and sulfation patterns. Our studies indicate that the absorption of CS is moderately correlated to percentage of chondroitin-6-sulfate while the anti-inflammatory activity may be weakly related to the molecular weight and the amount of total sulfation in the samples. Our in vitro studies could provide helpful screening tools for quick and"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1412.5562","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:31:02Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"4mdB/H9/9kammxflXY/0XCbl6EsaJoGKl0EDf1DPnNTmaazwaJITuaKayOOak41Rp0nyRMIOerjI5gdzEHLVAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T19:51:40.564273Z"},"content_sha256":"0396e8e4e91d1b2095667b81e1384842987a9c9502c0867e4382e3b06bc29b7c","schema_version":"1.0","event_id":"sha256:0396e8e4e91d1b2095667b81e1384842987a9c9502c0867e4382e3b06bc29b7c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/WL6ANLNUR5NEYE227N6ZDRT4VC/bundle.json","state_url":"https://pith.science/pith/WL6ANLNUR5NEYE227N6ZDRT4VC/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/WL6ANLNUR5NEYE227N6ZDRT4VC/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-11T19:51:40Z","links":{"resolver":"https://pith.science/pith/WL6ANLNUR5NEYE227N6ZDRT4VC","bundle":"https://pith.science/pith/WL6ANLNUR5NEYE227N6ZDRT4VC/bundle.json","state":"https://pith.science/pith/WL6ANLNUR5NEYE227N6ZDRT4VC/state.json","well_known_bundle":"https://pith.science/.well-known/pith/WL6ANLNUR5NEYE227N6ZDRT4VC/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:WL6ANLNUR5NEYE227N6ZDRT4VC","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"dcbde80d512e59d27b727f90802b605815fb4e3706710c1dbeca11de7c6e51c8","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2014-12-16T05:12:53Z","title_canon_sha256":"cc61e9b9be43c9cb966343381d58713a7b41ed710ed2faa9d4b9ade70df371d8"},"schema_version":"1.0","source":{"id":"1412.5562","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1412.5562","created_at":"2026-05-18T02:31:02Z"},{"alias_kind":"arxiv_version","alias_value":"1412.5562v1","created_at":"2026-05-18T02:31:02Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1412.5562","created_at":"2026-05-18T02:31:02Z"},{"alias_kind":"pith_short_12","alias_value":"WL6ANLNUR5NE","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_16","alias_value":"WL6ANLNUR5NEYE22","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_8","alias_value":"WL6ANLNU","created_at":"2026-05-18T12:28:54Z"}],"graph_snapshots":[{"event_id":"sha256:0396e8e4e91d1b2095667b81e1384842987a9c9502c0867e4382e3b06bc29b7c","target":"graph","created_at":"2026-05-18T02:31:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Here, we investigated the influence of physicochemical characteristics of chondroitin sulfate (CS) on its in vitro absorption and anti-inflammatory activity. We used eight different synthetic and natural CS samples with a range of molecular weights (7-35 kDa) and sulfation patterns. Our studies indicate that the absorption of CS is moderately correlated to percentage of chondroitin-6-sulfate while the anti-inflammatory activity may be weakly related to the molecular weight and the amount of total sulfation in the samples. Our in vitro studies could provide helpful screening tools for quick and","authors_text":"Ashby B. Bodine, George Huang, James Brooks, Lahari Surapaneni, Ramakrishna Podila, Vivian Haley-Zitlin","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2014-12-16T05:12:53Z","title":"Correlations between Chondroitin Sulfate Physicochemical Properties and its in-vitro Absorption and Anti-inflammatory Activity"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1412.5562","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f3deae0246d658bf099d8934c0bfebc1458b71fbcf728a50c850e8482e0f1b27","target":"record","created_at":"2026-05-18T02:31:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"dcbde80d512e59d27b727f90802b605815fb4e3706710c1dbeca11de7c6e51c8","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2014-12-16T05:12:53Z","title_canon_sha256":"cc61e9b9be43c9cb966343381d58713a7b41ed710ed2faa9d4b9ade70df371d8"},"schema_version":"1.0","source":{"id":"1412.5562","kind":"arxiv","version":1}},"canonical_sha256":"b2fc06adb48f5a4c135afb7d91c67ca88aa4bb43f74331da820c92b78b3cfb30","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b2fc06adb48f5a4c135afb7d91c67ca88aa4bb43f74331da820c92b78b3cfb30","first_computed_at":"2026-05-18T02:31:02.744181Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:31:02.744181Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"QX7Lr0sE5W9WYPwg4kXfANSTIEkCEqMeLIFWnZ+6Ql9JkNy87iyQorEiadJTBooxyOJrQknJ1tJMgMq5Pi5tBg==","signature_status":"signed_v1","signed_at":"2026-05-18T02:31:02.744633Z","signed_message":"canonical_sha256_bytes"},"source_id":"1412.5562","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f3deae0246d658bf099d8934c0bfebc1458b71fbcf728a50c850e8482e0f1b27","sha256:0396e8e4e91d1b2095667b81e1384842987a9c9502c0867e4382e3b06bc29b7c"],"state_sha256":"0ac7d308c126c3c1b50032c031cecba3afe95061dfea1c76f80797246e067c2b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"0+pC+N+Yq9L5PTDlwKCgfNCqbHCWeCc439yFviDM4htHqKg84y2xDsrZ8Xo2ZZqPpfr2DNKiAhTfcCwdYuktCg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-11T19:51:40.568292Z","bundle_sha256":"ec52cc377d2f8108f31fc26e5cad074710ca0a0a6539e49cbe131e4426a2a0b0"}}