{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2017:WLDJ4TO7S62FTG3AXPBIAFCORU","short_pith_number":"pith:WLDJ4TO7","schema_version":"1.0","canonical_sha256":"b2c69e4ddf97b4599b60bbc280144e8d1a92011d086f114838a6c48ff616f420","source":{"kind":"arxiv","id":"1711.03383","version":3},"attestation_state":"computed","paper":{"title":"An axon initial segment is required for temporal precision in action potential encoding by neuronal populations","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Andreas Neef, Barbara Feulner, Elinor Lazarov, Fred Wolf, J\\\"org Enderlein, Melanie Dannemeyer, Michael J. Gutnick","submitted_at":"2017-11-09T14:21:24Z","abstract_excerpt":"Central neurons initiate action potentials (APs) in the axon initial segment (AIS), a compartment characterized by a high concentration of voltage-dependent ion channels and specialized cytoskeletal anchoring proteins arranged in a regular nanoscale pattern. Although the AIS was a key evolutionary innovation in neurons, the functional benefits it confers are not clear. Using a mutation of the AIS cytoskeletal protein \\beta IV-spectrin, we here establish an in vitro model of neurons with a perturbed AIS architecture that retains nanoscale order but loses the ability to maintain a high NaV densi"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1711.03383","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2017-11-09T14:21:24Z","cross_cats_sorted":[],"title_canon_sha256":"91eb9af58f83efaea699954e407ed5da07b3be3c51cf01b5bb4ba698b13c9e3d","abstract_canon_sha256":"b601dbd1d3a8591faabb3ac504806f6443f9b7ed7ccbaa8d0122e67bd95f216e"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:58:56.190611Z","signature_b64":"+jdHmWNio0kFzFOJia7K1+FcCV55Uz+0UrlN5hhjPkXxGV6oXSquwZlvm8/I1mVzA6n6FxceuIUtym8FjvhbBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b2c69e4ddf97b4599b60bbc280144e8d1a92011d086f114838a6c48ff616f420","last_reissued_at":"2026-05-17T23:58:56.190167Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:58:56.190167Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"An axon initial segment is required for temporal precision in action potential encoding by neuronal populations","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Andreas Neef, Barbara Feulner, Elinor Lazarov, Fred Wolf, J\\\"org Enderlein, Melanie Dannemeyer, Michael J. Gutnick","submitted_at":"2017-11-09T14:21:24Z","abstract_excerpt":"Central neurons initiate action potentials (APs) in the axon initial segment (AIS), a compartment characterized by a high concentration of voltage-dependent ion channels and specialized cytoskeletal anchoring proteins arranged in a regular nanoscale pattern. Although the AIS was a key evolutionary innovation in neurons, the functional benefits it confers are not clear. Using a mutation of the AIS cytoskeletal protein \\beta IV-spectrin, we here establish an in vitro model of neurons with a perturbed AIS architecture that retains nanoscale order but loses the ability to maintain a high NaV densi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1711.03383","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1711.03383","created_at":"2026-05-17T23:58:56.190235+00:00"},{"alias_kind":"arxiv_version","alias_value":"1711.03383v3","created_at":"2026-05-17T23:58:56.190235+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1711.03383","created_at":"2026-05-17T23:58:56.190235+00:00"},{"alias_kind":"pith_short_12","alias_value":"WLDJ4TO7S62F","created_at":"2026-05-18T12:31:53.515858+00:00"},{"alias_kind":"pith_short_16","alias_value":"WLDJ4TO7S62FTG3A","created_at":"2026-05-18T12:31:53.515858+00:00"},{"alias_kind":"pith_short_8","alias_value":"WLDJ4TO7","created_at":"2026-05-18T12:31:53.515858+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU","json":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU.json","graph_json":"https://pith.science/api/pith-number/WLDJ4TO7S62FTG3AXPBIAFCORU/graph.json","events_json":"https://pith.science/api/pith-number/WLDJ4TO7S62FTG3AXPBIAFCORU/events.json","paper":"https://pith.science/paper/WLDJ4TO7"},"agent_actions":{"view_html":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU","download_json":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU.json","view_paper":"https://pith.science/paper/WLDJ4TO7","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1711.03383&json=true","fetch_graph":"https://pith.science/api/pith-number/WLDJ4TO7S62FTG3AXPBIAFCORU/graph.json","fetch_events":"https://pith.science/api/pith-number/WLDJ4TO7S62FTG3AXPBIAFCORU/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU/action/timestamp_anchor","attest_storage":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU/action/storage_attestation","attest_author":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU/action/author_attestation","sign_citation":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU/action/citation_signature","submit_replication":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU/action/replication_record"}},"created_at":"2026-05-17T23:58:56.190235+00:00","updated_at":"2026-05-17T23:58:56.190235+00:00"}