{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:WLDJ4TO7S62FTG3AXPBIAFCORU","short_pith_number":"pith:WLDJ4TO7","canonical_record":{"source":{"id":"1711.03383","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2017-11-09T14:21:24Z","cross_cats_sorted":[],"title_canon_sha256":"91eb9af58f83efaea699954e407ed5da07b3be3c51cf01b5bb4ba698b13c9e3d","abstract_canon_sha256":"b601dbd1d3a8591faabb3ac504806f6443f9b7ed7ccbaa8d0122e67bd95f216e"},"schema_version":"1.0"},"canonical_sha256":"b2c69e4ddf97b4599b60bbc280144e8d1a92011d086f114838a6c48ff616f420","source":{"kind":"arxiv","id":"1711.03383","version":3},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1711.03383","created_at":"2026-05-17T23:58:56Z"},{"alias_kind":"arxiv_version","alias_value":"1711.03383v3","created_at":"2026-05-17T23:58:56Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1711.03383","created_at":"2026-05-17T23:58:56Z"},{"alias_kind":"pith_short_12","alias_value":"WLDJ4TO7S62F","created_at":"2026-05-18T12:31:53Z"},{"alias_kind":"pith_short_16","alias_value":"WLDJ4TO7S62FTG3A","created_at":"2026-05-18T12:31:53Z"},{"alias_kind":"pith_short_8","alias_value":"WLDJ4TO7","created_at":"2026-05-18T12:31:53Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:WLDJ4TO7S62FTG3AXPBIAFCORU","target":"record","payload":{"canonical_record":{"source":{"id":"1711.03383","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2017-11-09T14:21:24Z","cross_cats_sorted":[],"title_canon_sha256":"91eb9af58f83efaea699954e407ed5da07b3be3c51cf01b5bb4ba698b13c9e3d","abstract_canon_sha256":"b601dbd1d3a8591faabb3ac504806f6443f9b7ed7ccbaa8d0122e67bd95f216e"},"schema_version":"1.0"},"canonical_sha256":"b2c69e4ddf97b4599b60bbc280144e8d1a92011d086f114838a6c48ff616f420","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:58:56.190611Z","signature_b64":"+jdHmWNio0kFzFOJia7K1+FcCV55Uz+0UrlN5hhjPkXxGV6oXSquwZlvm8/I1mVzA6n6FxceuIUtym8FjvhbBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b2c69e4ddf97b4599b60bbc280144e8d1a92011d086f114838a6c48ff616f420","last_reissued_at":"2026-05-17T23:58:56.190167Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:58:56.190167Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1711.03383","source_version":3,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:58:56Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"O67T+IMbWZ8/XxTALsEvJIl/t/xhu2uXEdTskDu6EPFomAqZVa3doj8gEZgPPdbCWYnXFhFcdEZvO3X8ExIrCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T18:57:32.636786Z"},"content_sha256":"a1f9751cc5e57b4e30db9248e4b9a54390f77aacf57242a5fd343be7b82988a1","schema_version":"1.0","event_id":"sha256:a1f9751cc5e57b4e30db9248e4b9a54390f77aacf57242a5fd343be7b82988a1"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:WLDJ4TO7S62FTG3AXPBIAFCORU","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"An axon initial segment is required for temporal precision in action potential encoding by neuronal populations","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Andreas Neef, Barbara Feulner, Elinor Lazarov, Fred Wolf, J\\\"org Enderlein, Melanie Dannemeyer, Michael J. Gutnick","submitted_at":"2017-11-09T14:21:24Z","abstract_excerpt":"Central neurons initiate action potentials (APs) in the axon initial segment (AIS), a compartment characterized by a high concentration of voltage-dependent ion channels and specialized cytoskeletal anchoring proteins arranged in a regular nanoscale pattern. Although the AIS was a key evolutionary innovation in neurons, the functional benefits it confers are not clear. Using a mutation of the AIS cytoskeletal protein \\beta IV-spectrin, we here establish an in vitro model of neurons with a perturbed AIS architecture that retains nanoscale order but loses the ability to maintain a high NaV densi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1711.03383","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:58:56Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"QRstmY/Etf4LRv0qEHhYSbo9Fb3140pxFTKDayPvHT7hnk8BrScYPod14fZmBZeo/fQVOTdxkT/rCJ/4hx0xAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T18:57:32.637135Z"},"content_sha256":"34cddc8726206a32d100cc422f9e1c20d708260c218f567e193b70c505ab5eeb","schema_version":"1.0","event_id":"sha256:34cddc8726206a32d100cc422f9e1c20d708260c218f567e193b70c505ab5eeb"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU/bundle.json","state_url":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/WLDJ4TO7S62FTG3AXPBIAFCORU/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-03T18:57:32Z","links":{"resolver":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU","bundle":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU/bundle.json","state":"https://pith.science/pith/WLDJ4TO7S62FTG3AXPBIAFCORU/state.json","well_known_bundle":"https://pith.science/.well-known/pith/WLDJ4TO7S62FTG3AXPBIAFCORU/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:WLDJ4TO7S62FTG3AXPBIAFCORU","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b601dbd1d3a8591faabb3ac504806f6443f9b7ed7ccbaa8d0122e67bd95f216e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2017-11-09T14:21:24Z","title_canon_sha256":"91eb9af58f83efaea699954e407ed5da07b3be3c51cf01b5bb4ba698b13c9e3d"},"schema_version":"1.0","source":{"id":"1711.03383","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1711.03383","created_at":"2026-05-17T23:58:56Z"},{"alias_kind":"arxiv_version","alias_value":"1711.03383v3","created_at":"2026-05-17T23:58:56Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1711.03383","created_at":"2026-05-17T23:58:56Z"},{"alias_kind":"pith_short_12","alias_value":"WLDJ4TO7S62F","created_at":"2026-05-18T12:31:53Z"},{"alias_kind":"pith_short_16","alias_value":"WLDJ4TO7S62FTG3A","created_at":"2026-05-18T12:31:53Z"},{"alias_kind":"pith_short_8","alias_value":"WLDJ4TO7","created_at":"2026-05-18T12:31:53Z"}],"graph_snapshots":[{"event_id":"sha256:34cddc8726206a32d100cc422f9e1c20d708260c218f567e193b70c505ab5eeb","target":"graph","created_at":"2026-05-17T23:58:56Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Central neurons initiate action potentials (APs) in the axon initial segment (AIS), a compartment characterized by a high concentration of voltage-dependent ion channels and specialized cytoskeletal anchoring proteins arranged in a regular nanoscale pattern. Although the AIS was a key evolutionary innovation in neurons, the functional benefits it confers are not clear. Using a mutation of the AIS cytoskeletal protein \\beta IV-spectrin, we here establish an in vitro model of neurons with a perturbed AIS architecture that retains nanoscale order but loses the ability to maintain a high NaV densi","authors_text":"Andreas Neef, Barbara Feulner, Elinor Lazarov, Fred Wolf, J\\\"org Enderlein, Melanie Dannemeyer, Michael J. Gutnick","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2017-11-09T14:21:24Z","title":"An axon initial segment is required for temporal precision in action potential encoding by neuronal populations"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1711.03383","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a1f9751cc5e57b4e30db9248e4b9a54390f77aacf57242a5fd343be7b82988a1","target":"record","created_at":"2026-05-17T23:58:56Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b601dbd1d3a8591faabb3ac504806f6443f9b7ed7ccbaa8d0122e67bd95f216e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2017-11-09T14:21:24Z","title_canon_sha256":"91eb9af58f83efaea699954e407ed5da07b3be3c51cf01b5bb4ba698b13c9e3d"},"schema_version":"1.0","source":{"id":"1711.03383","kind":"arxiv","version":3}},"canonical_sha256":"b2c69e4ddf97b4599b60bbc280144e8d1a92011d086f114838a6c48ff616f420","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b2c69e4ddf97b4599b60bbc280144e8d1a92011d086f114838a6c48ff616f420","first_computed_at":"2026-05-17T23:58:56.190167Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:58:56.190167Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"+jdHmWNio0kFzFOJia7K1+FcCV55Uz+0UrlN5hhjPkXxGV6oXSquwZlvm8/I1mVzA6n6FxceuIUtym8FjvhbBg==","signature_status":"signed_v1","signed_at":"2026-05-17T23:58:56.190611Z","signed_message":"canonical_sha256_bytes"},"source_id":"1711.03383","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a1f9751cc5e57b4e30db9248e4b9a54390f77aacf57242a5fd343be7b82988a1","sha256:34cddc8726206a32d100cc422f9e1c20d708260c218f567e193b70c505ab5eeb"],"state_sha256":"d948ea0667a99d0f97bf49b807358e6dba1c90c7458ef65b86870882a1be58e5"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"SMgZRZXy2+29mCzLGgf0MYeG9+8DGax/7YX21iRzQ/mhQe/AwjdSnYaJvkANofCyyBtkGhAOTvcxNl8lMKEZDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-03T18:57:32.639151Z","bundle_sha256":"3f670924edfba6e3e024d64df4fd5e2e378cc0e2a04ba8265d105c44c412189e"}}