{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:WLVZCCO5CI6KIT4UJOXBUJ6DBO","short_pith_number":"pith:WLVZCCO5","canonical_record":{"source":{"id":"1506.04842","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2015-06-16T06:03:20Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"326344a80b70bb5da9d340f66d7dc304780a3d7b4bfece82628888bfe53b12be","abstract_canon_sha256":"1932c685b4329d99727aec31ab8dfe2d0e549c20a42860500cd9b154a61fed28"},"schema_version":"1.0"},"canonical_sha256":"b2eb9109dd123ca44f944bae1a27c30bb9944b7f3066e64709e4964665e2465a","source":{"kind":"arxiv","id":"1506.04842","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1506.04842","created_at":"2026-05-18T01:48:05Z"},{"alias_kind":"arxiv_version","alias_value":"1506.04842v1","created_at":"2026-05-18T01:48:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1506.04842","created_at":"2026-05-18T01:48:05Z"},{"alias_kind":"pith_short_12","alias_value":"WLVZCCO5CI6K","created_at":"2026-05-18T12:29:47Z"},{"alias_kind":"pith_short_16","alias_value":"WLVZCCO5CI6KIT4U","created_at":"2026-05-18T12:29:47Z"},{"alias_kind":"pith_short_8","alias_value":"WLVZCCO5","created_at":"2026-05-18T12:29:47Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:WLVZCCO5CI6KIT4UJOXBUJ6DBO","target":"record","payload":{"canonical_record":{"source":{"id":"1506.04842","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2015-06-16T06:03:20Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"326344a80b70bb5da9d340f66d7dc304780a3d7b4bfece82628888bfe53b12be","abstract_canon_sha256":"1932c685b4329d99727aec31ab8dfe2d0e549c20a42860500cd9b154a61fed28"},"schema_version":"1.0"},"canonical_sha256":"b2eb9109dd123ca44f944bae1a27c30bb9944b7f3066e64709e4964665e2465a","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:48:05.775472Z","signature_b64":"/HZQgT4DHfSbrtLNgkjGv2sF0uUg9xuQQazIT8CBD4XNPszKxwNSFVkyNg2q7YrpZuB7vd+Yk124JEdVC4VzAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b2eb9109dd123ca44f944bae1a27c30bb9944b7f3066e64709e4964665e2465a","last_reissued_at":"2026-05-18T01:48:05.774870Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:48:05.774870Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1506.04842","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:48:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Lt0hHFSAyTsriB46Czdnx+wP0w3LCBM2MzTWoQozRq9LezAEEV3TPw8B+CXt5/53QYt+fxb2goAXzcGUMrNJAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-12T01:32:29.692135Z"},"content_sha256":"0d77905d0324e541504a5e0feedbaf6730a9a9a870fd4391702244927c4b326f","schema_version":"1.0","event_id":"sha256:0d77905d0324e541504a5e0feedbaf6730a9a9a870fd4391702244927c4b326f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:WLVZCCO5CI6KIT4UJOXBUJ6DBO","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Differential analysis of biological networks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["stat.AP"],"primary_cat":"stat.ME","authors_text":"Alastair Young, Da Ruan, Giovanni Montana","submitted_at":"2015-06-16T06:03:20Z","abstract_excerpt":"In cancer research, the comparison of gene expression or DNA methylation networks inferred from healthy controls and patients can lead to the discovery of biological pathways associated to the disease. As a cancer progresses, its signalling and control networks are subject to some degree of localised re-wiring. Being able to detect disrupted interaction patterns induced by the presence or progression of the disease can lead to the discovery of novel molecular diagnostic and prognostic signatures. Currently there is a lack of scalable statistical procedures for two-network comparisons aimed at "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1506.04842","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:48:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"nM/WjSQBj3/0JoVPahyxN9WnGLZktRQWQ1zBRvffxkLBb5G35A81BRpyCSoGQ1TESH9tuHrXNWoTfArhmqRTDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-12T01:32:29.692969Z"},"content_sha256":"16e4f489df8dee67ec1bd28c80ee59165121b3ce0badc99abe469b851baef606","schema_version":"1.0","event_id":"sha256:16e4f489df8dee67ec1bd28c80ee59165121b3ce0badc99abe469b851baef606"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/WLVZCCO5CI6KIT4UJOXBUJ6DBO/bundle.json","state_url":"https://pith.science/pith/WLVZCCO5CI6KIT4UJOXBUJ6DBO/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/WLVZCCO5CI6KIT4UJOXBUJ6DBO/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-12T01:32:29Z","links":{"resolver":"https://pith.science/pith/WLVZCCO5CI6KIT4UJOXBUJ6DBO","bundle":"https://pith.science/pith/WLVZCCO5CI6KIT4UJOXBUJ6DBO/bundle.json","state":"https://pith.science/pith/WLVZCCO5CI6KIT4UJOXBUJ6DBO/state.json","well_known_bundle":"https://pith.science/.well-known/pith/WLVZCCO5CI6KIT4UJOXBUJ6DBO/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:WLVZCCO5CI6KIT4UJOXBUJ6DBO","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"1932c685b4329d99727aec31ab8dfe2d0e549c20a42860500cd9b154a61fed28","cross_cats_sorted":["stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2015-06-16T06:03:20Z","title_canon_sha256":"326344a80b70bb5da9d340f66d7dc304780a3d7b4bfece82628888bfe53b12be"},"schema_version":"1.0","source":{"id":"1506.04842","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1506.04842","created_at":"2026-05-18T01:48:05Z"},{"alias_kind":"arxiv_version","alias_value":"1506.04842v1","created_at":"2026-05-18T01:48:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1506.04842","created_at":"2026-05-18T01:48:05Z"},{"alias_kind":"pith_short_12","alias_value":"WLVZCCO5CI6K","created_at":"2026-05-18T12:29:47Z"},{"alias_kind":"pith_short_16","alias_value":"WLVZCCO5CI6KIT4U","created_at":"2026-05-18T12:29:47Z"},{"alias_kind":"pith_short_8","alias_value":"WLVZCCO5","created_at":"2026-05-18T12:29:47Z"}],"graph_snapshots":[{"event_id":"sha256:16e4f489df8dee67ec1bd28c80ee59165121b3ce0badc99abe469b851baef606","target":"graph","created_at":"2026-05-18T01:48:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In cancer research, the comparison of gene expression or DNA methylation networks inferred from healthy controls and patients can lead to the discovery of biological pathways associated to the disease. As a cancer progresses, its signalling and control networks are subject to some degree of localised re-wiring. Being able to detect disrupted interaction patterns induced by the presence or progression of the disease can lead to the discovery of novel molecular diagnostic and prognostic signatures. Currently there is a lack of scalable statistical procedures for two-network comparisons aimed at ","authors_text":"Alastair Young, Da Ruan, Giovanni Montana","cross_cats":["stat.AP"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2015-06-16T06:03:20Z","title":"Differential analysis of biological networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1506.04842","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:0d77905d0324e541504a5e0feedbaf6730a9a9a870fd4391702244927c4b326f","target":"record","created_at":"2026-05-18T01:48:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"1932c685b4329d99727aec31ab8dfe2d0e549c20a42860500cd9b154a61fed28","cross_cats_sorted":["stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2015-06-16T06:03:20Z","title_canon_sha256":"326344a80b70bb5da9d340f66d7dc304780a3d7b4bfece82628888bfe53b12be"},"schema_version":"1.0","source":{"id":"1506.04842","kind":"arxiv","version":1}},"canonical_sha256":"b2eb9109dd123ca44f944bae1a27c30bb9944b7f3066e64709e4964665e2465a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b2eb9109dd123ca44f944bae1a27c30bb9944b7f3066e64709e4964665e2465a","first_computed_at":"2026-05-18T01:48:05.774870Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:48:05.774870Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"/HZQgT4DHfSbrtLNgkjGv2sF0uUg9xuQQazIT8CBD4XNPszKxwNSFVkyNg2q7YrpZuB7vd+Yk124JEdVC4VzAA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:48:05.775472Z","signed_message":"canonical_sha256_bytes"},"source_id":"1506.04842","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:0d77905d0324e541504a5e0feedbaf6730a9a9a870fd4391702244927c4b326f","sha256:16e4f489df8dee67ec1bd28c80ee59165121b3ce0badc99abe469b851baef606"],"state_sha256":"7cd3f1832a35741cbb8ad1abd17910637ab87d7f3dad94bfeaddc3c8208d85a5"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ZDPi0AATp1/CrEEeGtLpGocvIS3jv1NhDXBAenft/GXWu52Tut8OeaFIVWtMpNrm7Rq/FGm0EVKRpLUrdcZoBw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-12T01:32:29.697348Z","bundle_sha256":"b813a86430306849022f1468bc2d29db509b2be9c744bb5aa3649486ec63d9c9"}}