{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:WOP3XH27S7CHRX3EB6CJTOY6RA","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"fcc0b95a4bc9511dd4478d5b6470d31f408ef4e7ff42b5b195c1b24d07c2117e","cross_cats_sorted":["cs.IT","math.IT","q-bio.NC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-09-18T17:25:05Z","title_canon_sha256":"09f08ec386ae44d1b55ffbb37acdcd343c3e595c76cabcfd851fb9ab0f5f5315"},"schema_version":"1.0","source":{"id":"1609.05517","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1609.05517","created_at":"2026-05-18T00:58:56Z"},{"alias_kind":"arxiv_version","alias_value":"1609.05517v1","created_at":"2026-05-18T00:58:56Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1609.05517","created_at":"2026-05-18T00:58:56Z"},{"alias_kind":"pith_short_12","alias_value":"WOP3XH27S7CH","created_at":"2026-05-18T12:30:51Z"},{"alias_kind":"pith_short_16","alias_value":"WOP3XH27S7CHRX3E","created_at":"2026-05-18T12:30:51Z"},{"alias_kind":"pith_short_8","alias_value":"WOP3XH27","created_at":"2026-05-18T12:30:51Z"}],"graph_snapshots":[{"event_id":"sha256:c6f671c2d23a250b38dac798ed9c7d7608c3384ff22491af2b01e27518c39f9b","target":"graph","created_at":"2026-05-18T00:58:56Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Information theory provides powerful tools for understanding communication systems. This analysis can be applied to intercellular signal transduction, which is a means of chemical communication among cells and microbes. We discuss how to apply information-theoretic analysis to ligand-receptor systems, which form the signal carrier and receiver in intercellular signal transduction channels. We also discuss the applications of these results to neuroscience.","authors_text":"Andrew W. Eckford, Kenneth A. Loparo, Peter J. Thomas","cross_cats":["cs.IT","math.IT","q-bio.NC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-09-18T17:25:05Z","title":"Finite-State Channel Models for Signal Transduction in Neural Systems"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1609.05517","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:010c24680ce375d45b3af08201f9f4565803da2a19ae58b015e9307d4ffaea12","target":"record","created_at":"2026-05-18T00:58:56Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"fcc0b95a4bc9511dd4478d5b6470d31f408ef4e7ff42b5b195c1b24d07c2117e","cross_cats_sorted":["cs.IT","math.IT","q-bio.NC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-09-18T17:25:05Z","title_canon_sha256":"09f08ec386ae44d1b55ffbb37acdcd343c3e595c76cabcfd851fb9ab0f5f5315"},"schema_version":"1.0","source":{"id":"1609.05517","kind":"arxiv","version":1}},"canonical_sha256":"b39fbb9f5f97c478df640f8499bb1e88382d15b2e8b20280d4a78097989e468a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b39fbb9f5f97c478df640f8499bb1e88382d15b2e8b20280d4a78097989e468a","first_computed_at":"2026-05-18T00:58:56.523612Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:58:56.523612Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"FV4Y0jq6x8L6zWtmFwKCApMy8DuwPZFgOnoeKiKOMejRHbMkyNRME+nsuhdzBuIp0NLsOrDgrsUhle26w9lPCg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:58:56.524190Z","signed_message":"canonical_sha256_bytes"},"source_id":"1609.05517","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:010c24680ce375d45b3af08201f9f4565803da2a19ae58b015e9307d4ffaea12","sha256:c6f671c2d23a250b38dac798ed9c7d7608c3384ff22491af2b01e27518c39f9b"],"state_sha256":"3675810be83d32e1d07c22d93c5bb6900273c8b7a5eee1f8a1cfed567aed334f"}