{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2011:WQUZ4J5Y3UO2SHU5YFURK2NPRA","short_pith_number":"pith:WQUZ4J5Y","canonical_record":{"source":{"id":"1105.4486","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-05-23T12:58:26Z","cross_cats_sorted":[],"title_canon_sha256":"3c6ae67815f63481d5d261ca7044431786aa566917e2f7c0e6b623262c88ba21","abstract_canon_sha256":"f20275c8c6c9867ad27f7d9b47ee79d3e125213643ac0887c129b4bfd4efa7e4"},"schema_version":"1.0"},"canonical_sha256":"b4299e27b8dd1da91e9dc1691569af882be5067ae6492d77a88387dae168296c","source":{"kind":"arxiv","id":"1105.4486","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1105.4486","created_at":"2026-05-18T02:21:50Z"},{"alias_kind":"arxiv_version","alias_value":"1105.4486v2","created_at":"2026-05-18T02:21:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1105.4486","created_at":"2026-05-18T02:21:50Z"},{"alias_kind":"pith_short_12","alias_value":"WQUZ4J5Y3UO2","created_at":"2026-05-18T12:26:44Z"},{"alias_kind":"pith_short_16","alias_value":"WQUZ4J5Y3UO2SHU5","created_at":"2026-05-18T12:26:44Z"},{"alias_kind":"pith_short_8","alias_value":"WQUZ4J5Y","created_at":"2026-05-18T12:26:44Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2011:WQUZ4J5Y3UO2SHU5YFURK2NPRA","target":"record","payload":{"canonical_record":{"source":{"id":"1105.4486","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-05-23T12:58:26Z","cross_cats_sorted":[],"title_canon_sha256":"3c6ae67815f63481d5d261ca7044431786aa566917e2f7c0e6b623262c88ba21","abstract_canon_sha256":"f20275c8c6c9867ad27f7d9b47ee79d3e125213643ac0887c129b4bfd4efa7e4"},"schema_version":"1.0"},"canonical_sha256":"b4299e27b8dd1da91e9dc1691569af882be5067ae6492d77a88387dae168296c","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:21:50.108843Z","signature_b64":"JZS3E33I98x68BHQDfue6L63ZubJa7e7rZ0OSXnJp7XTA3XaHmmPViheI7HjUxvrKpfp6Qzj/S2sYuRt9HlkAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b4299e27b8dd1da91e9dc1691569af882be5067ae6492d77a88387dae168296c","last_reissued_at":"2026-05-18T02:21:50.108234Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:21:50.108234Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1105.4486","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:21:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"os3C9AqItL3d4VQ1M4BwmLHWNiNG4ioZQRzmgs5FrZVHBAPLNcB2cC6KvMYPFJGG1SzCZJtNX5KB8MiETJG0CQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T18:51:25.991473Z"},"content_sha256":"42e15c9d7925c1d75d4fca11de18f32e2c7365e98426b20601cf603710fc9d3b","schema_version":"1.0","event_id":"sha256:42e15c9d7925c1d75d4fca11de18f32e2c7365e98426b20601cf603710fc9d3b"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2011:WQUZ4J5Y3UO2SHU5YFURK2NPRA","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A machine learning pipeline for discriminant pathways identification","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Annalisa Barla, Cesare Furlanello, Giuseppe Jurman, Margherita Squillario, Michele Filosi, Roberto Visintainer, Samantha Riccadonna","submitted_at":"2011-05-23T12:58:26Z","abstract_excerpt":"Motivation: Identifying the molecular pathways more prone to disruption during a pathological process is a key task in network medicine and, more in general, in systems biology.\n  Results: In this work we propose a pipeline that couples a machine learning solution for molecular profiling with a recent network comparison method. The pipeline can identify changes occurring between specific sub-modules of networks built in a case-control biomarker study, discriminating key groups of genes whose interactions are modified by an underlying condition. The proposal is independent from the classificati"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1105.4486","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:21:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"KEBViHODnk0enQDYXSjHihoyg5asMmby78cqVURDtDsVVwLLRiTojYpr3qcKiFnooOVHgsjlsKoOtk7fCc/bDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T18:51:25.991877Z"},"content_sha256":"e9e6a083076c51ad3589c13616176d63ce78acc65ff1eeaa6406596264e2e6bb","schema_version":"1.0","event_id":"sha256:e9e6a083076c51ad3589c13616176d63ce78acc65ff1eeaa6406596264e2e6bb"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/WQUZ4J5Y3UO2SHU5YFURK2NPRA/bundle.json","state_url":"https://pith.science/pith/WQUZ4J5Y3UO2SHU5YFURK2NPRA/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/WQUZ4J5Y3UO2SHU5YFURK2NPRA/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-26T18:51:25Z","links":{"resolver":"https://pith.science/pith/WQUZ4J5Y3UO2SHU5YFURK2NPRA","bundle":"https://pith.science/pith/WQUZ4J5Y3UO2SHU5YFURK2NPRA/bundle.json","state":"https://pith.science/pith/WQUZ4J5Y3UO2SHU5YFURK2NPRA/state.json","well_known_bundle":"https://pith.science/.well-known/pith/WQUZ4J5Y3UO2SHU5YFURK2NPRA/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:WQUZ4J5Y3UO2SHU5YFURK2NPRA","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f20275c8c6c9867ad27f7d9b47ee79d3e125213643ac0887c129b4bfd4efa7e4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-05-23T12:58:26Z","title_canon_sha256":"3c6ae67815f63481d5d261ca7044431786aa566917e2f7c0e6b623262c88ba21"},"schema_version":"1.0","source":{"id":"1105.4486","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1105.4486","created_at":"2026-05-18T02:21:50Z"},{"alias_kind":"arxiv_version","alias_value":"1105.4486v2","created_at":"2026-05-18T02:21:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1105.4486","created_at":"2026-05-18T02:21:50Z"},{"alias_kind":"pith_short_12","alias_value":"WQUZ4J5Y3UO2","created_at":"2026-05-18T12:26:44Z"},{"alias_kind":"pith_short_16","alias_value":"WQUZ4J5Y3UO2SHU5","created_at":"2026-05-18T12:26:44Z"},{"alias_kind":"pith_short_8","alias_value":"WQUZ4J5Y","created_at":"2026-05-18T12:26:44Z"}],"graph_snapshots":[{"event_id":"sha256:e9e6a083076c51ad3589c13616176d63ce78acc65ff1eeaa6406596264e2e6bb","target":"graph","created_at":"2026-05-18T02:21:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Motivation: Identifying the molecular pathways more prone to disruption during a pathological process is a key task in network medicine and, more in general, in systems biology.\n  Results: In this work we propose a pipeline that couples a machine learning solution for molecular profiling with a recent network comparison method. The pipeline can identify changes occurring between specific sub-modules of networks built in a case-control biomarker study, discriminating key groups of genes whose interactions are modified by an underlying condition. The proposal is independent from the classificati","authors_text":"Annalisa Barla, Cesare Furlanello, Giuseppe Jurman, Margherita Squillario, Michele Filosi, Roberto Visintainer, Samantha Riccadonna","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-05-23T12:58:26Z","title":"A machine learning pipeline for discriminant pathways identification"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1105.4486","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:42e15c9d7925c1d75d4fca11de18f32e2c7365e98426b20601cf603710fc9d3b","target":"record","created_at":"2026-05-18T02:21:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f20275c8c6c9867ad27f7d9b47ee79d3e125213643ac0887c129b4bfd4efa7e4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-05-23T12:58:26Z","title_canon_sha256":"3c6ae67815f63481d5d261ca7044431786aa566917e2f7c0e6b623262c88ba21"},"schema_version":"1.0","source":{"id":"1105.4486","kind":"arxiv","version":2}},"canonical_sha256":"b4299e27b8dd1da91e9dc1691569af882be5067ae6492d77a88387dae168296c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b4299e27b8dd1da91e9dc1691569af882be5067ae6492d77a88387dae168296c","first_computed_at":"2026-05-18T02:21:50.108234Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:21:50.108234Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"JZS3E33I98x68BHQDfue6L63ZubJa7e7rZ0OSXnJp7XTA3XaHmmPViheI7HjUxvrKpfp6Qzj/S2sYuRt9HlkAA==","signature_status":"signed_v1","signed_at":"2026-05-18T02:21:50.108843Z","signed_message":"canonical_sha256_bytes"},"source_id":"1105.4486","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:42e15c9d7925c1d75d4fca11de18f32e2c7365e98426b20601cf603710fc9d3b","sha256:e9e6a083076c51ad3589c13616176d63ce78acc65ff1eeaa6406596264e2e6bb"],"state_sha256":"166ad0c5a5d57b05de58cd331d92a50c082a30417a264341bd7cd40df11af15a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"MvitL3lJyU8sioeSfeocuYog7RrMJ38TubN21l/ZA7TIxzM992eurmWrRvdafHsf7usU5nVEwIS/4N171E+MCQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-26T18:51:25.994261Z","bundle_sha256":"89e5381a27a084b5527f9fdb3e25b57d06cb2287cf34bc73aaaf39281b73e1ca"}}