{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:WRBKMUGOTEOPY2O5QL3W5OWET4","short_pith_number":"pith:WRBKMUGO","canonical_record":{"source":{"id":"2112.11903","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2021-12-22T14:36:29Z","cross_cats_sorted":[],"title_canon_sha256":"f8825480af287d6e5673b086e79c2f85d42cb044efe6ab44719a7fa5bb2576c4","abstract_canon_sha256":"bc0b211a9970b554e66663f83f6ce74e349d74dbb3aa6e343f1e29541a1e805c"},"schema_version":"1.0"},"canonical_sha256":"b442a650ce991cfc69dd82f76ebac49f251c83600d743b867205d7abf475cdcd","source":{"kind":"arxiv","id":"2112.11903","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2112.11903","created_at":"2026-07-05T03:43:12Z"},{"alias_kind":"arxiv_version","alias_value":"2112.11903v1","created_at":"2026-07-05T03:43:12Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2112.11903","created_at":"2026-07-05T03:43:12Z"},{"alias_kind":"pith_short_12","alias_value":"WRBKMUGOTEOP","created_at":"2026-07-05T03:43:12Z"},{"alias_kind":"pith_short_16","alias_value":"WRBKMUGOTEOPY2O5","created_at":"2026-07-05T03:43:12Z"},{"alias_kind":"pith_short_8","alias_value":"WRBKMUGO","created_at":"2026-07-05T03:43:12Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:WRBKMUGOTEOPY2O5QL3W5OWET4","target":"record","payload":{"canonical_record":{"source":{"id":"2112.11903","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2021-12-22T14:36:29Z","cross_cats_sorted":[],"title_canon_sha256":"f8825480af287d6e5673b086e79c2f85d42cb044efe6ab44719a7fa5bb2576c4","abstract_canon_sha256":"bc0b211a9970b554e66663f83f6ce74e349d74dbb3aa6e343f1e29541a1e805c"},"schema_version":"1.0"},"canonical_sha256":"b442a650ce991cfc69dd82f76ebac49f251c83600d743b867205d7abf475cdcd","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T03:43:12.885934Z","signature_b64":"n4RharQ8ABT7aXYOI8YAxxJknIycxalDpKCpKZ++CxVsH/jIr32iMIYGAL6uXnyUKv9FWFnzAWt/qazLIswOCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b442a650ce991cfc69dd82f76ebac49f251c83600d743b867205d7abf475cdcd","last_reissued_at":"2026-07-05T03:43:12.885470Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T03:43:12.885470Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2112.11903","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:43:12Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"roZoajnx9tHA09aHdlSswCp6BR4ejVyo7+tdsM/BsMiUypsTkqATQImV3NqTDLeAWVXwD0dG2IyYeCKfOaZTCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-05T08:05:43.368870Z"},"content_sha256":"dd5b9941b909e83efe56b837b5ddfa1c91a6b4367a63711fe48cbd92b2070c82","schema_version":"1.0","event_id":"sha256:dd5b9941b909e83efe56b837b5ddfa1c91a6b4367a63711fe48cbd92b2070c82"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:WRBKMUGOTEOPY2O5QL3W5OWET4","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"The utility of wearable devices in assessing ambulatory impairments of people with multiple sclerosis in free-living conditions","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"Aki Rintala, Amos A Folarin, Ana Isabel Guerrero, Ana Zabalza, Callum Stewart, Giancarlo Comi, Gloria Dalla Costa, Heet Sankesara, Inez Myin-Germeys, Letizia Leocani, Matthew Hotopf, Melinda Magyari, Nicholas Cummins, Pauline Conde, Per Soelberg S{\\o}rensen, Petroula Laiou, RADAR-CNS consortium, Raquel Bailon, Richard JB Dobson, Sara Simblett, Shaoxiong Sun, Shuo Liu, Srinivasan Vairavan, Til Wykes, Vaibhav A Narayan, Yatharth Ranjan, Yuezhou Zhang, Zulqarnain Rashid","submitted_at":"2021-12-22T14:36:29Z","abstract_excerpt":"Multiple sclerosis (MS) is a progressive inflammatory and neurodegenerative disease of the central nervous system affecting over 2.5 million people globally. In-clinic six-minute walk test (6MWT) is a widely used objective measure to evaluate the progression of MS. Yet, it has limitations such as the need for a clinical visit and a proper walkway. The widespread use of wearable devices capable of depicting patients activity profiles has the potential to assess the level of MS-induced disability in free-living conditions. In this work, we extracted 96 activity features in different temporal gra"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2112.11903","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2112.11903/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:43:12Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"dAC0A2KBvv/w7hm08pmOz3s2lyRiuvqCDJegJnXhikQP/1HudMmfRP5CBcpOyc5FMWH2SmDFrX7e3Viq5ApMBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-05T08:05:43.369246Z"},"content_sha256":"90d241d8d1784c6eb6af79b41d379f14b2bb06bb2117fd29d75b0aea117b4387","schema_version":"1.0","event_id":"sha256:90d241d8d1784c6eb6af79b41d379f14b2bb06bb2117fd29d75b0aea117b4387"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/WRBKMUGOTEOPY2O5QL3W5OWET4/bundle.json","state_url":"https://pith.science/pith/WRBKMUGOTEOPY2O5QL3W5OWET4/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/WRBKMUGOTEOPY2O5QL3W5OWET4/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-05T08:05:43Z","links":{"resolver":"https://pith.science/pith/WRBKMUGOTEOPY2O5QL3W5OWET4","bundle":"https://pith.science/pith/WRBKMUGOTEOPY2O5QL3W5OWET4/bundle.json","state":"https://pith.science/pith/WRBKMUGOTEOPY2O5QL3W5OWET4/state.json","well_known_bundle":"https://pith.science/.well-known/pith/WRBKMUGOTEOPY2O5QL3W5OWET4/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:WRBKMUGOTEOPY2O5QL3W5OWET4","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"bc0b211a9970b554e66663f83f6ce74e349d74dbb3aa6e343f1e29541a1e805c","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2021-12-22T14:36:29Z","title_canon_sha256":"f8825480af287d6e5673b086e79c2f85d42cb044efe6ab44719a7fa5bb2576c4"},"schema_version":"1.0","source":{"id":"2112.11903","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2112.11903","created_at":"2026-07-05T03:43:12Z"},{"alias_kind":"arxiv_version","alias_value":"2112.11903v1","created_at":"2026-07-05T03:43:12Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2112.11903","created_at":"2026-07-05T03:43:12Z"},{"alias_kind":"pith_short_12","alias_value":"WRBKMUGOTEOP","created_at":"2026-07-05T03:43:12Z"},{"alias_kind":"pith_short_16","alias_value":"WRBKMUGOTEOPY2O5","created_at":"2026-07-05T03:43:12Z"},{"alias_kind":"pith_short_8","alias_value":"WRBKMUGO","created_at":"2026-07-05T03:43:12Z"}],"graph_snapshots":[{"event_id":"sha256:90d241d8d1784c6eb6af79b41d379f14b2bb06bb2117fd29d75b0aea117b4387","target":"graph","created_at":"2026-07-05T03:43:12Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2112.11903/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Multiple sclerosis (MS) is a progressive inflammatory and neurodegenerative disease of the central nervous system affecting over 2.5 million people globally. In-clinic six-minute walk test (6MWT) is a widely used objective measure to evaluate the progression of MS. Yet, it has limitations such as the need for a clinical visit and a proper walkway. The widespread use of wearable devices capable of depicting patients activity profiles has the potential to assess the level of MS-induced disability in free-living conditions. In this work, we extracted 96 activity features in different temporal gra","authors_text":"Aki Rintala, Amos A Folarin, Ana Isabel Guerrero, Ana Zabalza, Callum Stewart, Giancarlo Comi, Gloria Dalla Costa, Heet Sankesara, Inez Myin-Germeys, Letizia Leocani, Matthew Hotopf, Melinda Magyari, Nicholas Cummins, Pauline Conde, Per Soelberg S{\\o}rensen, Petroula Laiou, RADAR-CNS consortium, Raquel Bailon, Richard JB Dobson, Sara Simblett, Shaoxiong Sun, Shuo Liu, Srinivasan Vairavan, Til Wykes, Vaibhav A Narayan, Yatharth Ranjan, Yuezhou Zhang, Zulqarnain Rashid","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2021-12-22T14:36:29Z","title":"The utility of wearable devices in assessing ambulatory impairments of people with multiple sclerosis in free-living conditions"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2112.11903","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:dd5b9941b909e83efe56b837b5ddfa1c91a6b4367a63711fe48cbd92b2070c82","target":"record","created_at":"2026-07-05T03:43:12Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"bc0b211a9970b554e66663f83f6ce74e349d74dbb3aa6e343f1e29541a1e805c","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2021-12-22T14:36:29Z","title_canon_sha256":"f8825480af287d6e5673b086e79c2f85d42cb044efe6ab44719a7fa5bb2576c4"},"schema_version":"1.0","source":{"id":"2112.11903","kind":"arxiv","version":1}},"canonical_sha256":"b442a650ce991cfc69dd82f76ebac49f251c83600d743b867205d7abf475cdcd","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b442a650ce991cfc69dd82f76ebac49f251c83600d743b867205d7abf475cdcd","first_computed_at":"2026-07-05T03:43:12.885470Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T03:43:12.885470Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"n4RharQ8ABT7aXYOI8YAxxJknIycxalDpKCpKZ++CxVsH/jIr32iMIYGAL6uXnyUKv9FWFnzAWt/qazLIswOCA==","signature_status":"signed_v1","signed_at":"2026-07-05T03:43:12.885934Z","signed_message":"canonical_sha256_bytes"},"source_id":"2112.11903","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:dd5b9941b909e83efe56b837b5ddfa1c91a6b4367a63711fe48cbd92b2070c82","sha256:90d241d8d1784c6eb6af79b41d379f14b2bb06bb2117fd29d75b0aea117b4387"],"state_sha256":"b9d71950fab615acb119611805d088f5ba6a3ca1cf3b17146e80c146d8e02a65"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"yUFI61g3Lk3oifE6aFZet2Wsekr63146YuWH8n6o057mz7JVWLo6VKcw86tNCowQs75XbrxjiK1SNoXBn/LHDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-05T08:05:43.371220Z","bundle_sha256":"2135829acedd1d31c918f5f5fe20634af83b9836202c827bf3b96590be576b05"}}