{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2012:WTTIKTRHNBDBKB7UTL3VYILYYM","short_pith_number":"pith:WTTIKTRH","canonical_record":{"source":{"id":"1211.5807","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2012-11-25T21:00:17Z","cross_cats_sorted":[],"title_canon_sha256":"045934b5415c89e9ce9c4792f0df0ddc8a4cf7e6b7656d9d2f744d87b8c41d5b","abstract_canon_sha256":"4a89886ea81cdf0e8242f313033735284a98ab9ae93b5559eb7abf0d61ee6b28"},"schema_version":"1.0"},"canonical_sha256":"b4e6854e2768461507f49af75c2178c30cda33981a9a32bda806a1f2906ab1d5","source":{"kind":"arxiv","id":"1211.5807","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1211.5807","created_at":"2026-05-18T03:35:38Z"},{"alias_kind":"arxiv_version","alias_value":"1211.5807v2","created_at":"2026-05-18T03:35:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1211.5807","created_at":"2026-05-18T03:35:38Z"},{"alias_kind":"pith_short_12","alias_value":"WTTIKTRHNBDB","created_at":"2026-05-18T12:27:27Z"},{"alias_kind":"pith_short_16","alias_value":"WTTIKTRHNBDBKB7U","created_at":"2026-05-18T12:27:27Z"},{"alias_kind":"pith_short_8","alias_value":"WTTIKTRH","created_at":"2026-05-18T12:27:27Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2012:WTTIKTRHNBDBKB7UTL3VYILYYM","target":"record","payload":{"canonical_record":{"source":{"id":"1211.5807","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2012-11-25T21:00:17Z","cross_cats_sorted":[],"title_canon_sha256":"045934b5415c89e9ce9c4792f0df0ddc8a4cf7e6b7656d9d2f744d87b8c41d5b","abstract_canon_sha256":"4a89886ea81cdf0e8242f313033735284a98ab9ae93b5559eb7abf0d61ee6b28"},"schema_version":"1.0"},"canonical_sha256":"b4e6854e2768461507f49af75c2178c30cda33981a9a32bda806a1f2906ab1d5","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:35:38.046637Z","signature_b64":"r35VJWC7WUf2Hjs5fnzdXAHH98X3tZEVmkV5C7YzAbdeJ7MSZiwuCL8RmP8Q1LQZOs0EyXlVd5isocpnZyHOCQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b4e6854e2768461507f49af75c2178c30cda33981a9a32bda806a1f2906ab1d5","last_reissued_at":"2026-05-18T03:35:38.045768Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:35:38.045768Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1211.5807","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:35:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"jJSueUXO/PXPkSXKHOFdTNRtV8kspDQahX/cFbHZkXc/3Pmmx2hZWdirz13gIOEb/AJnerdk//c6rEy6F8WaDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T03:39:53.923017Z"},"content_sha256":"fe9e04fe7d6ac370784878e442ad03ae20bf98f9875656622c2ab16063c69c5f","schema_version":"1.0","event_id":"sha256:fe9e04fe7d6ac370784878e442ad03ae20bf98f9875656622c2ab16063c69c5f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2012:WTTIKTRHNBDBKB7UTL3VYILYYM","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"HIV drug resistance: problems and perspectives","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Pleuni S. Pennings","submitted_at":"2012-11-25T21:00:17Z","abstract_excerpt":"Access to combination antiretroviral treatment (ART) has improved greatly over recent years. At the end of 2011, more than eight million HIV infected people were receiving antiretroviral therapy in low-income and middle-income countries. ART generally works well in keeping the virus suppressed and the patient healthy. However, treatment only works as long as the virus is not resistant against the drugs used. In the last decades, HIV treatments have become better and better at slowing down the evolution of drug resistance, so that some patients are treated for many years without having any resi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1211.5807","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:35:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"PeuR57t10i+S8xcV+LD12C8Xh9tvOwyzgEwBeRALnFM1d/nom5xE76uQ0YKIgCA6a46ziXrNQSYrXslCWAsJDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T03:39:53.923724Z"},"content_sha256":"79949c58e9ade83a4e8755773cf92d3b780bd6538f91dfa6bad3c4ad9f4e8fd2","schema_version":"1.0","event_id":"sha256:79949c58e9ade83a4e8755773cf92d3b780bd6538f91dfa6bad3c4ad9f4e8fd2"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/WTTIKTRHNBDBKB7UTL3VYILYYM/bundle.json","state_url":"https://pith.science/pith/WTTIKTRHNBDBKB7UTL3VYILYYM/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/WTTIKTRHNBDBKB7UTL3VYILYYM/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-09T03:39:53Z","links":{"resolver":"https://pith.science/pith/WTTIKTRHNBDBKB7UTL3VYILYYM","bundle":"https://pith.science/pith/WTTIKTRHNBDBKB7UTL3VYILYYM/bundle.json","state":"https://pith.science/pith/WTTIKTRHNBDBKB7UTL3VYILYYM/state.json","well_known_bundle":"https://pith.science/.well-known/pith/WTTIKTRHNBDBKB7UTL3VYILYYM/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:WTTIKTRHNBDBKB7UTL3VYILYYM","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"4a89886ea81cdf0e8242f313033735284a98ab9ae93b5559eb7abf0d61ee6b28","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2012-11-25T21:00:17Z","title_canon_sha256":"045934b5415c89e9ce9c4792f0df0ddc8a4cf7e6b7656d9d2f744d87b8c41d5b"},"schema_version":"1.0","source":{"id":"1211.5807","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1211.5807","created_at":"2026-05-18T03:35:38Z"},{"alias_kind":"arxiv_version","alias_value":"1211.5807v2","created_at":"2026-05-18T03:35:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1211.5807","created_at":"2026-05-18T03:35:38Z"},{"alias_kind":"pith_short_12","alias_value":"WTTIKTRHNBDB","created_at":"2026-05-18T12:27:27Z"},{"alias_kind":"pith_short_16","alias_value":"WTTIKTRHNBDBKB7U","created_at":"2026-05-18T12:27:27Z"},{"alias_kind":"pith_short_8","alias_value":"WTTIKTRH","created_at":"2026-05-18T12:27:27Z"}],"graph_snapshots":[{"event_id":"sha256:79949c58e9ade83a4e8755773cf92d3b780bd6538f91dfa6bad3c4ad9f4e8fd2","target":"graph","created_at":"2026-05-18T03:35:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Access to combination antiretroviral treatment (ART) has improved greatly over recent years. At the end of 2011, more than eight million HIV infected people were receiving antiretroviral therapy in low-income and middle-income countries. ART generally works well in keeping the virus suppressed and the patient healthy. However, treatment only works as long as the virus is not resistant against the drugs used. In the last decades, HIV treatments have become better and better at slowing down the evolution of drug resistance, so that some patients are treated for many years without having any resi","authors_text":"Pleuni S. Pennings","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2012-11-25T21:00:17Z","title":"HIV drug resistance: problems and perspectives"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1211.5807","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:fe9e04fe7d6ac370784878e442ad03ae20bf98f9875656622c2ab16063c69c5f","target":"record","created_at":"2026-05-18T03:35:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"4a89886ea81cdf0e8242f313033735284a98ab9ae93b5559eb7abf0d61ee6b28","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2012-11-25T21:00:17Z","title_canon_sha256":"045934b5415c89e9ce9c4792f0df0ddc8a4cf7e6b7656d9d2f744d87b8c41d5b"},"schema_version":"1.0","source":{"id":"1211.5807","kind":"arxiv","version":2}},"canonical_sha256":"b4e6854e2768461507f49af75c2178c30cda33981a9a32bda806a1f2906ab1d5","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b4e6854e2768461507f49af75c2178c30cda33981a9a32bda806a1f2906ab1d5","first_computed_at":"2026-05-18T03:35:38.045768Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:35:38.045768Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"r35VJWC7WUf2Hjs5fnzdXAHH98X3tZEVmkV5C7YzAbdeJ7MSZiwuCL8RmP8Q1LQZOs0EyXlVd5isocpnZyHOCQ==","signature_status":"signed_v1","signed_at":"2026-05-18T03:35:38.046637Z","signed_message":"canonical_sha256_bytes"},"source_id":"1211.5807","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:fe9e04fe7d6ac370784878e442ad03ae20bf98f9875656622c2ab16063c69c5f","sha256:79949c58e9ade83a4e8755773cf92d3b780bd6538f91dfa6bad3c4ad9f4e8fd2"],"state_sha256":"85f2e5d9f421973b0a5b7cd7a76f49511e65cbd3d91fd874297bca629332f4d2"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"uWE+i8IERBCwL5H0mLxuUQp8F7iGqd3IUzykR+SwvWdVbiwh+H1+jy4CXLyM78907AbxAeJgUJs3isPYwpXTBw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-09T03:39:53.927617Z","bundle_sha256":"f91600f42f18b965772ebe98d7db05786b89ff0cfc25c2a91d490e4668cdede4"}}