{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:WYLVCJUXLEFNV3IBWWDJQGMPEB","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"390d31ebc62fb7800f44de8d59c6d7ee5f9d9036137121e81e7bbba689916760","cross_cats_sorted":["physics.flu-dyn","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2014-12-03T17:30:35Z","title_canon_sha256":"c4590b8082644bb50d0bb8807fd950f90afcbe17f0854673faf596d53e547f18"},"schema_version":"1.0","source":{"id":"1412.1770","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1412.1770","created_at":"2026-05-18T02:32:06Z"},{"alias_kind":"arxiv_version","alias_value":"1412.1770v1","created_at":"2026-05-18T02:32:06Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1412.1770","created_at":"2026-05-18T02:32:06Z"},{"alias_kind":"pith_short_12","alias_value":"WYLVCJUXLEFN","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_16","alias_value":"WYLVCJUXLEFNV3IB","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_8","alias_value":"WYLVCJUX","created_at":"2026-05-18T12:28:54Z"}],"graph_snapshots":[{"event_id":"sha256:6e240994e2178db31c85b89c853cb97146e3e8badafd7d4fca031e3d5b5fa432","target":"graph","created_at":"2026-05-18T02:32:06Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Microfluidic biosensors have been utilized for sensing a wide range of antigens using numerous configurations. Bead based microfluidic sensors have been a popular modality due to the plug and play nature of analyte choice and the favorable geometry of spherical sensor scaffolds. While constriction of beads against fluid flow remains a popular method to immobilize the sensor, it results in poor fluidic regimes and shear conditions around sensor beads that can affect sensor performance. We present an alternative means of sensor bead immobilization using poly-carbonate membrane. This system resul","authors_text":"Aaron P. Maharry, Brett C. Geiger, Kinshuk Mitra, Michael F. Tweedle, Preethi Chidambaram, Ronald X. Xu","cross_cats":["physics.flu-dyn","q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2014-12-03T17:30:35Z","title":"Non-constrictive bead immobilization leading to decreased and uniform shear stress in microfluidic bead-based ELISA"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1412.1770","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:45e63e224403bca752452cda26bda30509fb198e56625035851f7634ba1a0aba","target":"record","created_at":"2026-05-18T02:32:06Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"390d31ebc62fb7800f44de8d59c6d7ee5f9d9036137121e81e7bbba689916760","cross_cats_sorted":["physics.flu-dyn","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2014-12-03T17:30:35Z","title_canon_sha256":"c4590b8082644bb50d0bb8807fd950f90afcbe17f0854673faf596d53e547f18"},"schema_version":"1.0","source":{"id":"1412.1770","kind":"arxiv","version":1}},"canonical_sha256":"b617512697590adaed01b58698198f206326975d41b8582ef480fdb5337e7fe0","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b617512697590adaed01b58698198f206326975d41b8582ef480fdb5337e7fe0","first_computed_at":"2026-05-18T02:32:06.551383Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:32:06.551383Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"2TriNYCix2sWJBFCzMqKoyoFy5CBt9r4eW1U1y6i+JG0P6F/dRAAhGDADu7lAo16hZq9AIbzV53/eb6VoGOgCQ==","signature_status":"signed_v1","signed_at":"2026-05-18T02:32:06.551767Z","signed_message":"canonical_sha256_bytes"},"source_id":"1412.1770","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:45e63e224403bca752452cda26bda30509fb198e56625035851f7634ba1a0aba","sha256:6e240994e2178db31c85b89c853cb97146e3e8badafd7d4fca031e3d5b5fa432"],"state_sha256":"e5b4b3f85e6421c60b2c67cdce13dbfb998db70da4e33eb70eccbd28eb8b049e"}