{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:WZTWIFO3AVGHUYYVBSX4C5LEUB","short_pith_number":"pith:WZTWIFO3","canonical_record":{"source":{"id":"1711.07397","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2017-11-20T16:34:00Z","cross_cats_sorted":["cond-mat.other","physics.chem-ph"],"title_canon_sha256":"77b8c8d616c3c5a55b7f269668a8cac39166da45009349e99e880fd7d3959d92","abstract_canon_sha256":"0ce6cbc296f82bd840b844600bd749a5dc18d00a7cb483b31d62b2957b05f465"},"schema_version":"1.0"},"canonical_sha256":"b6676415db054c7a63150cafc17564a066745be3dd56e66b6afb8f88ef2a3774","source":{"kind":"arxiv","id":"1711.07397","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1711.07397","created_at":"2026-05-18T00:15:37Z"},{"alias_kind":"arxiv_version","alias_value":"1711.07397v2","created_at":"2026-05-18T00:15:37Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1711.07397","created_at":"2026-05-18T00:15:37Z"},{"alias_kind":"pith_short_12","alias_value":"WZTWIFO3AVGH","created_at":"2026-05-18T12:31:53Z"},{"alias_kind":"pith_short_16","alias_value":"WZTWIFO3AVGHUYYV","created_at":"2026-05-18T12:31:53Z"},{"alias_kind":"pith_short_8","alias_value":"WZTWIFO3","created_at":"2026-05-18T12:31:53Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:WZTWIFO3AVGHUYYVBSX4C5LEUB","target":"record","payload":{"canonical_record":{"source":{"id":"1711.07397","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2017-11-20T16:34:00Z","cross_cats_sorted":["cond-mat.other","physics.chem-ph"],"title_canon_sha256":"77b8c8d616c3c5a55b7f269668a8cac39166da45009349e99e880fd7d3959d92","abstract_canon_sha256":"0ce6cbc296f82bd840b844600bd749a5dc18d00a7cb483b31d62b2957b05f465"},"schema_version":"1.0"},"canonical_sha256":"b6676415db054c7a63150cafc17564a066745be3dd56e66b6afb8f88ef2a3774","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:15:37.003291Z","signature_b64":"WNJCOivJoEqNJ/xNGrB28N8EvHjcI5kaUYKJhbGqHEWrOAhrhnwyjfUch7/grlskSV+62jGPRPg6p11mR1LSAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b6676415db054c7a63150cafc17564a066745be3dd56e66b6afb8f88ef2a3774","last_reissued_at":"2026-05-18T00:15:37.002834Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:15:37.002834Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1711.07397","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:15:37Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+C3KD4YJ4z7su3QQkgNgPqwCbgM4nw2r5HfQdIhCBaugqncSA0t5mjxc7/L1rfJPTfhm3mVuR6O3aJMpc7lFBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-27T14:00:06.171564Z"},"content_sha256":"987ddae4576f74f4558232d7499800afa9ac7f8aecb22494eddd4e53ec042825","schema_version":"1.0","event_id":"sha256:987ddae4576f74f4558232d7499800afa9ac7f8aecb22494eddd4e53ec042825"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:WZTWIFO3AVGHUYYVBSX4C5LEUB","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A validation strategy for in silico generated aptamers","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.other","physics.chem-ph"],"primary_cat":"q-bio.QM","authors_text":"E. Alfinito, F. Ciriaco, R. Cataldo","submitted_at":"2017-11-20T16:34:00Z","abstract_excerpt":"The selection of high-affinity aptamers is of paramount interest for clinical and technological applications. A novel strategy is proposed to validate the reliability of the 3D structures of aptamers, produced in silico by using free software. The procedure consists of three steps: a. the production of a large set of conformations for each candidate aptamer, b. the rigid docking upon the receptor, c. the topological and electrical characterization of the products. Steps a. and b. allow a global binding score of the ligand-receptor complexes based on the distribution of the \"effective affinity\""},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1711.07397","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:15:37Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9suMtsNNSRvjWO/KKm3BsHzMjTWGlx99aV9FLMN8Z83hmFVXB+k148/AH4G0GNQauvoeTDNFjOkntCHLiMHPAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-27T14:00:06.171908Z"},"content_sha256":"bbdf94010d05d9d21c07227b838e51be491798bff75764290f6e65d2f0a9772d","schema_version":"1.0","event_id":"sha256:bbdf94010d05d9d21c07227b838e51be491798bff75764290f6e65d2f0a9772d"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/WZTWIFO3AVGHUYYVBSX4C5LEUB/bundle.json","state_url":"https://pith.science/pith/WZTWIFO3AVGHUYYVBSX4C5LEUB/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/WZTWIFO3AVGHUYYVBSX4C5LEUB/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-27T14:00:06Z","links":{"resolver":"https://pith.science/pith/WZTWIFO3AVGHUYYVBSX4C5LEUB","bundle":"https://pith.science/pith/WZTWIFO3AVGHUYYVBSX4C5LEUB/bundle.json","state":"https://pith.science/pith/WZTWIFO3AVGHUYYVBSX4C5LEUB/state.json","well_known_bundle":"https://pith.science/.well-known/pith/WZTWIFO3AVGHUYYVBSX4C5LEUB/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:WZTWIFO3AVGHUYYVBSX4C5LEUB","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0ce6cbc296f82bd840b844600bd749a5dc18d00a7cb483b31d62b2957b05f465","cross_cats_sorted":["cond-mat.other","physics.chem-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2017-11-20T16:34:00Z","title_canon_sha256":"77b8c8d616c3c5a55b7f269668a8cac39166da45009349e99e880fd7d3959d92"},"schema_version":"1.0","source":{"id":"1711.07397","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1711.07397","created_at":"2026-05-18T00:15:37Z"},{"alias_kind":"arxiv_version","alias_value":"1711.07397v2","created_at":"2026-05-18T00:15:37Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1711.07397","created_at":"2026-05-18T00:15:37Z"},{"alias_kind":"pith_short_12","alias_value":"WZTWIFO3AVGH","created_at":"2026-05-18T12:31:53Z"},{"alias_kind":"pith_short_16","alias_value":"WZTWIFO3AVGHUYYV","created_at":"2026-05-18T12:31:53Z"},{"alias_kind":"pith_short_8","alias_value":"WZTWIFO3","created_at":"2026-05-18T12:31:53Z"}],"graph_snapshots":[{"event_id":"sha256:bbdf94010d05d9d21c07227b838e51be491798bff75764290f6e65d2f0a9772d","target":"graph","created_at":"2026-05-18T00:15:37Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The selection of high-affinity aptamers is of paramount interest for clinical and technological applications. A novel strategy is proposed to validate the reliability of the 3D structures of aptamers, produced in silico by using free software. The procedure consists of three steps: a. the production of a large set of conformations for each candidate aptamer, b. the rigid docking upon the receptor, c. the topological and electrical characterization of the products. Steps a. and b. allow a global binding score of the ligand-receptor complexes based on the distribution of the \"effective affinity\"","authors_text":"E. Alfinito, F. Ciriaco, R. Cataldo","cross_cats":["cond-mat.other","physics.chem-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2017-11-20T16:34:00Z","title":"A validation strategy for in silico generated aptamers"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1711.07397","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:987ddae4576f74f4558232d7499800afa9ac7f8aecb22494eddd4e53ec042825","target":"record","created_at":"2026-05-18T00:15:37Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0ce6cbc296f82bd840b844600bd749a5dc18d00a7cb483b31d62b2957b05f465","cross_cats_sorted":["cond-mat.other","physics.chem-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2017-11-20T16:34:00Z","title_canon_sha256":"77b8c8d616c3c5a55b7f269668a8cac39166da45009349e99e880fd7d3959d92"},"schema_version":"1.0","source":{"id":"1711.07397","kind":"arxiv","version":2}},"canonical_sha256":"b6676415db054c7a63150cafc17564a066745be3dd56e66b6afb8f88ef2a3774","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b6676415db054c7a63150cafc17564a066745be3dd56e66b6afb8f88ef2a3774","first_computed_at":"2026-05-18T00:15:37.002834Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:15:37.002834Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"WNJCOivJoEqNJ/xNGrB28N8EvHjcI5kaUYKJhbGqHEWrOAhrhnwyjfUch7/grlskSV+62jGPRPg6p11mR1LSAA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:15:37.003291Z","signed_message":"canonical_sha256_bytes"},"source_id":"1711.07397","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:987ddae4576f74f4558232d7499800afa9ac7f8aecb22494eddd4e53ec042825","sha256:bbdf94010d05d9d21c07227b838e51be491798bff75764290f6e65d2f0a9772d"],"state_sha256":"4bd3929d574b6b42823d11e812f9d5b98877a8629edc2a8a702efe6742fcf053"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"H3O5FdVc5is1I64LOKhw2HXEG7GsmQxsbW4bnxvSekzDsLcB0VFXR6ob7lL3/ILBcAN714w34KIxYvfh3qySCA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-27T14:00:06.173933Z","bundle_sha256":"49c33fe7eb61452672ed57851731ee94a8154ba452d11cb1c4c4cff2cea5a3f0"}}