{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2010:X27P7O7ORHLY5ISLJQOC44M34J","short_pith_number":"pith:X27P7O7O","canonical_record":{"source":{"id":"1006.2908","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2010-06-15T07:31:50Z","cross_cats_sorted":["q-bio.MN"],"title_canon_sha256":"044f2718549900a4b876dcb39fd8d69d680fa13708d6d4b7b44b57af5b0934ce","abstract_canon_sha256":"9b190d7bf8e641ed38b22224c5fd94a79afe9fbc65bcdbd3f279cd0c00f789cc"},"schema_version":"1.0"},"canonical_sha256":"bebeffbbee89d78ea24b4c1c2e719be26c4fae9270bd14c00a7e46c62a09e6f2","source":{"kind":"arxiv","id":"1006.2908","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1006.2908","created_at":"2026-05-18T04:33:07Z"},{"alias_kind":"arxiv_version","alias_value":"1006.2908v1","created_at":"2026-05-18T04:33:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1006.2908","created_at":"2026-05-18T04:33:07Z"},{"alias_kind":"pith_short_12","alias_value":"X27P7O7ORHLY","created_at":"2026-05-18T12:26:17Z"},{"alias_kind":"pith_short_16","alias_value":"X27P7O7ORHLY5ISL","created_at":"2026-05-18T12:26:17Z"},{"alias_kind":"pith_short_8","alias_value":"X27P7O7O","created_at":"2026-05-18T12:26:17Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2010:X27P7O7ORHLY5ISLJQOC44M34J","target":"record","payload":{"canonical_record":{"source":{"id":"1006.2908","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2010-06-15T07:31:50Z","cross_cats_sorted":["q-bio.MN"],"title_canon_sha256":"044f2718549900a4b876dcb39fd8d69d680fa13708d6d4b7b44b57af5b0934ce","abstract_canon_sha256":"9b190d7bf8e641ed38b22224c5fd94a79afe9fbc65bcdbd3f279cd0c00f789cc"},"schema_version":"1.0"},"canonical_sha256":"bebeffbbee89d78ea24b4c1c2e719be26c4fae9270bd14c00a7e46c62a09e6f2","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:33:07.328999Z","signature_b64":"nUoG0eo14+86SMx0laaRBdnHQvhg3U9O/XS9Vz6cKkfs+Z43cleFzpU1ZlCb7LRUZlQC32AsklqfQh98O7dnBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"bebeffbbee89d78ea24b4c1c2e719be26c4fae9270bd14c00a7e46c62a09e6f2","last_reissued_at":"2026-05-18T04:33:07.328110Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:33:07.328110Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1006.2908","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:33:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"eg/nXtDMIN6zZ2jyTrZn5lhOqBI+VetMrFMmXYHukqfvKy6Vf+cJJ2NkdXD3aimUKjjEXKa3tAYKkX/eNLAJDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T07:14:01.570714Z"},"content_sha256":"79009a52e73415ba43366ffb6ad7b126325e1122b9943c0d62f7217c93575101","schema_version":"1.0","event_id":"sha256:79009a52e73415ba43366ffb6ad7b126325e1122b9943c0d62f7217c93575101"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2010:X27P7O7ORHLY5ISLJQOC44M34J","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Critical properties of complex fitness landscapes","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.MN"],"primary_cat":"q-bio.PE","authors_text":"Arend Hintze, Bj{\\o}rn {\\O}stman, Christoph Adami (KGI)","submitted_at":"2010-06-15T07:31:50Z","abstract_excerpt":"Evolutionary adaptation is the process that increases the fit of a population to the fitness landscape it inhabits. As a consequence, evolutionary dynamics is shaped, constrained, and channeled, by that fitness landscape. Much work has been expended to understand the evolutionary dynamics of adapting populations, but much less is known about the structure of the landscapes. Here, we study the global and local structure of complex fitness landscapes of interacting loci that describe protein folds or sets of interacting genes forming pathways or modules. We find that in these landscapes, high pe"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1006.2908","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:33:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"WcBnMCVruFIQ0gF2xh4ABSQEi1AC5AxJhChvq1kudfXbgWba1SDil8tSCFGPIUaIKd6VhCKksjmUnIOCBHpxBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T07:14:01.571441Z"},"content_sha256":"610a1cf7a4e857d71c4fc2b31129afddae64bfe4fb186351169afbe64a09ca6a","schema_version":"1.0","event_id":"sha256:610a1cf7a4e857d71c4fc2b31129afddae64bfe4fb186351169afbe64a09ca6a"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/X27P7O7ORHLY5ISLJQOC44M34J/bundle.json","state_url":"https://pith.science/pith/X27P7O7ORHLY5ISLJQOC44M34J/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/X27P7O7ORHLY5ISLJQOC44M34J/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-05T07:14:01Z","links":{"resolver":"https://pith.science/pith/X27P7O7ORHLY5ISLJQOC44M34J","bundle":"https://pith.science/pith/X27P7O7ORHLY5ISLJQOC44M34J/bundle.json","state":"https://pith.science/pith/X27P7O7ORHLY5ISLJQOC44M34J/state.json","well_known_bundle":"https://pith.science/.well-known/pith/X27P7O7ORHLY5ISLJQOC44M34J/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:X27P7O7ORHLY5ISLJQOC44M34J","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"9b190d7bf8e641ed38b22224c5fd94a79afe9fbc65bcdbd3f279cd0c00f789cc","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2010-06-15T07:31:50Z","title_canon_sha256":"044f2718549900a4b876dcb39fd8d69d680fa13708d6d4b7b44b57af5b0934ce"},"schema_version":"1.0","source":{"id":"1006.2908","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1006.2908","created_at":"2026-05-18T04:33:07Z"},{"alias_kind":"arxiv_version","alias_value":"1006.2908v1","created_at":"2026-05-18T04:33:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1006.2908","created_at":"2026-05-18T04:33:07Z"},{"alias_kind":"pith_short_12","alias_value":"X27P7O7ORHLY","created_at":"2026-05-18T12:26:17Z"},{"alias_kind":"pith_short_16","alias_value":"X27P7O7ORHLY5ISL","created_at":"2026-05-18T12:26:17Z"},{"alias_kind":"pith_short_8","alias_value":"X27P7O7O","created_at":"2026-05-18T12:26:17Z"}],"graph_snapshots":[{"event_id":"sha256:610a1cf7a4e857d71c4fc2b31129afddae64bfe4fb186351169afbe64a09ca6a","target":"graph","created_at":"2026-05-18T04:33:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Evolutionary adaptation is the process that increases the fit of a population to the fitness landscape it inhabits. As a consequence, evolutionary dynamics is shaped, constrained, and channeled, by that fitness landscape. Much work has been expended to understand the evolutionary dynamics of adapting populations, but much less is known about the structure of the landscapes. Here, we study the global and local structure of complex fitness landscapes of interacting loci that describe protein folds or sets of interacting genes forming pathways or modules. We find that in these landscapes, high pe","authors_text":"Arend Hintze, Bj{\\o}rn {\\O}stman, Christoph Adami (KGI)","cross_cats":["q-bio.MN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2010-06-15T07:31:50Z","title":"Critical properties of complex fitness landscapes"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1006.2908","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:79009a52e73415ba43366ffb6ad7b126325e1122b9943c0d62f7217c93575101","target":"record","created_at":"2026-05-18T04:33:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"9b190d7bf8e641ed38b22224c5fd94a79afe9fbc65bcdbd3f279cd0c00f789cc","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2010-06-15T07:31:50Z","title_canon_sha256":"044f2718549900a4b876dcb39fd8d69d680fa13708d6d4b7b44b57af5b0934ce"},"schema_version":"1.0","source":{"id":"1006.2908","kind":"arxiv","version":1}},"canonical_sha256":"bebeffbbee89d78ea24b4c1c2e719be26c4fae9270bd14c00a7e46c62a09e6f2","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"bebeffbbee89d78ea24b4c1c2e719be26c4fae9270bd14c00a7e46c62a09e6f2","first_computed_at":"2026-05-18T04:33:07.328110Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:33:07.328110Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"nUoG0eo14+86SMx0laaRBdnHQvhg3U9O/XS9Vz6cKkfs+Z43cleFzpU1ZlCb7LRUZlQC32AsklqfQh98O7dnBA==","signature_status":"signed_v1","signed_at":"2026-05-18T04:33:07.328999Z","signed_message":"canonical_sha256_bytes"},"source_id":"1006.2908","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:79009a52e73415ba43366ffb6ad7b126325e1122b9943c0d62f7217c93575101","sha256:610a1cf7a4e857d71c4fc2b31129afddae64bfe4fb186351169afbe64a09ca6a"],"state_sha256":"be02351bc7a00687202ad23d6ca8e028846c3c6b4d098575fe8dd876e4bdcd6f"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"jtL6jOKQX3Ex9yzYxsSdmRA4gWEv2U52VvUpR6OzfINM4mFvIOaCCnbgv4SRpg7Hyh4d2aHU+9f7izhjEvwRCA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-05T07:14:01.575201Z","bundle_sha256":"54c25f6c9aeb6808896e01d74710f96e9928fee97e44ac2f95b485411830e97d"}}