{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:X2SUQIHWQ7KKGI4O7DAKG2JBTT","short_pith_number":"pith:X2SUQIHW","canonical_record":{"source":{"id":"2109.07190","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.BM","submitted_at":"2021-09-15T10:10:20Z","cross_cats_sorted":[],"title_canon_sha256":"22f2b6f0a434721bf2413e075ddb916b2743c40af8bb66d4cbbe0192c9acbfb1","abstract_canon_sha256":"72bfd6624381516cf8c8cdace3ebf58f7900dc4cc8bde54c434b0736576bef22"},"schema_version":"1.0"},"canonical_sha256":"bea54820f687d4a3238ef8c0a369219cd71e0f6238be263e8e3e723d607d5cd6","source":{"kind":"arxiv","id":"2109.07190","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2109.07190","created_at":"2026-07-05T03:14:39Z"},{"alias_kind":"arxiv_version","alias_value":"2109.07190v1","created_at":"2026-07-05T03:14:39Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2109.07190","created_at":"2026-07-05T03:14:39Z"},{"alias_kind":"pith_short_12","alias_value":"X2SUQIHWQ7KK","created_at":"2026-07-05T03:14:39Z"},{"alias_kind":"pith_short_16","alias_value":"X2SUQIHWQ7KKGI4O","created_at":"2026-07-05T03:14:39Z"},{"alias_kind":"pith_short_8","alias_value":"X2SUQIHW","created_at":"2026-07-05T03:14:39Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:X2SUQIHWQ7KKGI4O7DAKG2JBTT","target":"record","payload":{"canonical_record":{"source":{"id":"2109.07190","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.BM","submitted_at":"2021-09-15T10:10:20Z","cross_cats_sorted":[],"title_canon_sha256":"22f2b6f0a434721bf2413e075ddb916b2743c40af8bb66d4cbbe0192c9acbfb1","abstract_canon_sha256":"72bfd6624381516cf8c8cdace3ebf58f7900dc4cc8bde54c434b0736576bef22"},"schema_version":"1.0"},"canonical_sha256":"bea54820f687d4a3238ef8c0a369219cd71e0f6238be263e8e3e723d607d5cd6","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T03:14:39.702934Z","signature_b64":"aS1DjmWytajpKjOejFPM9cEKcDcxApHmD3h6LxRc68BhZwharftMK0VrXFiAUZ+aH9d1QbGxkLYcuWwiOWJzAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"bea54820f687d4a3238ef8c0a369219cd71e0f6238be263e8e3e723d607d5cd6","last_reissued_at":"2026-07-05T03:14:39.702585Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T03:14:39.702585Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2109.07190","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:14:39Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Jxy/xKg5qlqWmrRvIXCkzGa74uWzgMr3tnd0xBVx7BRLI76HwNT6I/CW0f2Lhpo0lM0bWqNkzJh/ptbQx0SBBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-06T03:11:10.324486Z"},"content_sha256":"ff6b2c01fee289682532e0ec40a0fb347dfbec05ba160b3ddd445b6d17d0ef7d","schema_version":"1.0","event_id":"sha256:ff6b2c01fee289682532e0ec40a0fb347dfbec05ba160b3ddd445b6d17d0ef7d"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:X2SUQIHWQ7KKGI4O7DAKG2JBTT","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A novel hotspot of gelsolin instability and aggregation propensity triggers a new mechanism of amyloidosis","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Alberto Barbiroli, Ana Fakin, Carmina Natale, Edi Gabellieri, Elisa Fagnani, Eloise Mastrangelo, Gianluca Presciuttini, Irene Boniardi, Luisa Diomede, Marco Gobbi, Mario Milani, Marten Beeg, Matteo de Rosa, Michela Bollati, Patrizia Cioni, Rebecca Alemani, Toni Giorgino","submitted_at":"2021-09-15T10:10:20Z","abstract_excerpt":"The multidomain protein gelsolin (GSN) is composed of six homologous modules, sequentially named G1 to G6. Single point substitutions in this protein are responsible for AGel amyloidosis, a hereditary disease characterized by progressive corneal lattice dystrophy, cutis laxa, and polyneuropathy. Several different amyloidogenic variants of GSN have been identified over the years, but only the most common D187N/Y mutants, in G2, have been thoroughly characterized, and the underlying functional mechanistic link between mutation, altered protein structure, susceptibility to aberrant furin cleavage"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2109.07190","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2109.07190/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:14:39Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"CH1qs+SlBQOby9aMLDZ7tu8p+NcpnJ6Aue0lx7FaPfdJNA2AHJKzlzSxUArXp+aEdeeC2LQyaL3pw0PjnEQrCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-06T03:11:10.325026Z"},"content_sha256":"22204324c7cdc43e6254ebd670176d16fb04852148fed48c76670ac2d210dec4","schema_version":"1.0","event_id":"sha256:22204324c7cdc43e6254ebd670176d16fb04852148fed48c76670ac2d210dec4"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/X2SUQIHWQ7KKGI4O7DAKG2JBTT/bundle.json","state_url":"https://pith.science/pith/X2SUQIHWQ7KKGI4O7DAKG2JBTT/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/X2SUQIHWQ7KKGI4O7DAKG2JBTT/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-06T03:11:10Z","links":{"resolver":"https://pith.science/pith/X2SUQIHWQ7KKGI4O7DAKG2JBTT","bundle":"https://pith.science/pith/X2SUQIHWQ7KKGI4O7DAKG2JBTT/bundle.json","state":"https://pith.science/pith/X2SUQIHWQ7KKGI4O7DAKG2JBTT/state.json","well_known_bundle":"https://pith.science/.well-known/pith/X2SUQIHWQ7KKGI4O7DAKG2JBTT/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:X2SUQIHWQ7KKGI4O7DAKG2JBTT","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"72bfd6624381516cf8c8cdace3ebf58f7900dc4cc8bde54c434b0736576bef22","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.BM","submitted_at":"2021-09-15T10:10:20Z","title_canon_sha256":"22f2b6f0a434721bf2413e075ddb916b2743c40af8bb66d4cbbe0192c9acbfb1"},"schema_version":"1.0","source":{"id":"2109.07190","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2109.07190","created_at":"2026-07-05T03:14:39Z"},{"alias_kind":"arxiv_version","alias_value":"2109.07190v1","created_at":"2026-07-05T03:14:39Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2109.07190","created_at":"2026-07-05T03:14:39Z"},{"alias_kind":"pith_short_12","alias_value":"X2SUQIHWQ7KK","created_at":"2026-07-05T03:14:39Z"},{"alias_kind":"pith_short_16","alias_value":"X2SUQIHWQ7KKGI4O","created_at":"2026-07-05T03:14:39Z"},{"alias_kind":"pith_short_8","alias_value":"X2SUQIHW","created_at":"2026-07-05T03:14:39Z"}],"graph_snapshots":[{"event_id":"sha256:22204324c7cdc43e6254ebd670176d16fb04852148fed48c76670ac2d210dec4","target":"graph","created_at":"2026-07-05T03:14:39Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2109.07190/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The multidomain protein gelsolin (GSN) is composed of six homologous modules, sequentially named G1 to G6. Single point substitutions in this protein are responsible for AGel amyloidosis, a hereditary disease characterized by progressive corneal lattice dystrophy, cutis laxa, and polyneuropathy. Several different amyloidogenic variants of GSN have been identified over the years, but only the most common D187N/Y mutants, in G2, have been thoroughly characterized, and the underlying functional mechanistic link between mutation, altered protein structure, susceptibility to aberrant furin cleavage","authors_text":"Alberto Barbiroli, Ana Fakin, Carmina Natale, Edi Gabellieri, Elisa Fagnani, Eloise Mastrangelo, Gianluca Presciuttini, Irene Boniardi, Luisa Diomede, Marco Gobbi, Mario Milani, Marten Beeg, Matteo de Rosa, Michela Bollati, Patrizia Cioni, Rebecca Alemani, Toni Giorgino","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.BM","submitted_at":"2021-09-15T10:10:20Z","title":"A novel hotspot of gelsolin instability and aggregation propensity triggers a new mechanism of amyloidosis"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2109.07190","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:ff6b2c01fee289682532e0ec40a0fb347dfbec05ba160b3ddd445b6d17d0ef7d","target":"record","created_at":"2026-07-05T03:14:39Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"72bfd6624381516cf8c8cdace3ebf58f7900dc4cc8bde54c434b0736576bef22","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.BM","submitted_at":"2021-09-15T10:10:20Z","title_canon_sha256":"22f2b6f0a434721bf2413e075ddb916b2743c40af8bb66d4cbbe0192c9acbfb1"},"schema_version":"1.0","source":{"id":"2109.07190","kind":"arxiv","version":1}},"canonical_sha256":"bea54820f687d4a3238ef8c0a369219cd71e0f6238be263e8e3e723d607d5cd6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"bea54820f687d4a3238ef8c0a369219cd71e0f6238be263e8e3e723d607d5cd6","first_computed_at":"2026-07-05T03:14:39.702585Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T03:14:39.702585Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"aS1DjmWytajpKjOejFPM9cEKcDcxApHmD3h6LxRc68BhZwharftMK0VrXFiAUZ+aH9d1QbGxkLYcuWwiOWJzAw==","signature_status":"signed_v1","signed_at":"2026-07-05T03:14:39.702934Z","signed_message":"canonical_sha256_bytes"},"source_id":"2109.07190","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:ff6b2c01fee289682532e0ec40a0fb347dfbec05ba160b3ddd445b6d17d0ef7d","sha256:22204324c7cdc43e6254ebd670176d16fb04852148fed48c76670ac2d210dec4"],"state_sha256":"78b98f5ce63c2da29d67f00c33f726befb53b456a2c190b6d53a7a3e6e89ebc3"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"DhSz/XlRDf6681+2QfnEIFAEPfXCi7swq/Fp37fgk5gkX21k34OX1VvhvJboELw4edgHWUOKRezucPDMCo3oBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-06T03:11:10.330313Z","bundle_sha256":"a2750adfc08f195ebcbd4f0778db25de4afbaf0194de972c5ef10509d2717d8d"}}