{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:XC2HCPCXDIQ7TZMRCVUJGVHHD7","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"fa48d8a0d6a20144540fdf1bc9484b417ba7aa6b581c5676fdff66fd5bb05c56","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2014-08-18T19:52:51Z","title_canon_sha256":"c9d98f3717866ee3176194a46e6db685ce18fdf7d516a2db0f1f19ac0703299d"},"schema_version":"1.0","source":{"id":"1408.4108","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1408.4108","created_at":"2026-05-18T02:37:44Z"},{"alias_kind":"arxiv_version","alias_value":"1408.4108v3","created_at":"2026-05-18T02:37:44Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1408.4108","created_at":"2026-05-18T02:37:44Z"},{"alias_kind":"pith_short_12","alias_value":"XC2HCPCXDIQ7","created_at":"2026-05-18T12:28:57Z"},{"alias_kind":"pith_short_16","alias_value":"XC2HCPCXDIQ7TZMR","created_at":"2026-05-18T12:28:57Z"},{"alias_kind":"pith_short_8","alias_value":"XC2HCPCX","created_at":"2026-05-18T12:28:57Z"}],"graph_snapshots":[{"event_id":"sha256:783b3b244cd70035cc251ee86242e84b7651764303c235de24180cde5d50bcdf","target":"graph","created_at":"2026-05-18T02:37:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Genetic interactions can strongly influence the fitness effects of individual mutations, yet the impact of these epistatic interactions on evolutionary dynamics remains poorly understood. Here we investigate the evolutionary role of epistasis over 50,000 generations in a well-studied laboratory evolution experiment in E. coli. The extensive duration of this experiment provides a unique window into the effects of epistasis during long-term adaptation to a constant environment. Guided by analytical results in the weak-mutation limit, we develop a computational framework to assess the compatibili","authors_text":"Benjamin H. Good, Michael M. Desai","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2014-08-18T19:52:51Z","title":"The impact of macroscopic epistasis on long-term evolutionary dynamics"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1408.4108","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:5d9123869669c2e748c9e694c1d166615363e348a351359b1420ae36b6cb1a48","target":"record","created_at":"2026-05-18T02:37:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"fa48d8a0d6a20144540fdf1bc9484b417ba7aa6b581c5676fdff66fd5bb05c56","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2014-08-18T19:52:51Z","title_canon_sha256":"c9d98f3717866ee3176194a46e6db685ce18fdf7d516a2db0f1f19ac0703299d"},"schema_version":"1.0","source":{"id":"1408.4108","kind":"arxiv","version":3}},"canonical_sha256":"b8b4713c571a21f9e59115689354e71fe6575fa47cdc264fc9eace589c7d11c9","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b8b4713c571a21f9e59115689354e71fe6575fa47cdc264fc9eace589c7d11c9","first_computed_at":"2026-05-18T02:37:44.378797Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:37:44.378797Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"evdZmv723JLUzV9O9iMtjgf2qKa7CEWThk3UU7QQhJL1VfnRpRFnZVo90/5GnzU2rp/wltjYbBMI9+lS3qY5CQ==","signature_status":"signed_v1","signed_at":"2026-05-18T02:37:44.379387Z","signed_message":"canonical_sha256_bytes"},"source_id":"1408.4108","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:5d9123869669c2e748c9e694c1d166615363e348a351359b1420ae36b6cb1a48","sha256:783b3b244cd70035cc251ee86242e84b7651764303c235de24180cde5d50bcdf"],"state_sha256":"a9d00f101ec0c988922bfb5ed007dbcadd71fbbf8690e6fe0387c0d8daf9193d"}