{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:XOLA7SO67UPGFNSH7RCQZZKJJ7","short_pith_number":"pith:XOLA7SO6","canonical_record":{"source":{"id":"2411.12944","kind":"arxiv","version":4},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2024-11-20T00:28:36Z","cross_cats_sorted":[],"title_canon_sha256":"d4a6411674574af9659ead64ec28ea7d667440109d6faf80af897123062f4a32","abstract_canon_sha256":"e43007cecf27cf19d4d30c24b3ac7e32bcb7eb9a504f0958630b5469f7929c8f"},"schema_version":"1.0"},"canonical_sha256":"bb960fc9defd1e62b647fc450ce5494ffb7eec27195389b6ff0cc6626319da5e","source":{"kind":"arxiv","id":"2411.12944","version":4},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2411.12944","created_at":"2026-07-05T11:07:16Z"},{"alias_kind":"arxiv_version","alias_value":"2411.12944v4","created_at":"2026-07-05T11:07:16Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2411.12944","created_at":"2026-07-05T11:07:16Z"},{"alias_kind":"pith_short_12","alias_value":"XOLA7SO67UPG","created_at":"2026-07-05T11:07:16Z"},{"alias_kind":"pith_short_16","alias_value":"XOLA7SO67UPGFNSH","created_at":"2026-07-05T11:07:16Z"},{"alias_kind":"pith_short_8","alias_value":"XOLA7SO6","created_at":"2026-07-05T11:07:16Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:XOLA7SO67UPGFNSH7RCQZZKJJ7","target":"record","payload":{"canonical_record":{"source":{"id":"2411.12944","kind":"arxiv","version":4},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2024-11-20T00:28:36Z","cross_cats_sorted":[],"title_canon_sha256":"d4a6411674574af9659ead64ec28ea7d667440109d6faf80af897123062f4a32","abstract_canon_sha256":"e43007cecf27cf19d4d30c24b3ac7e32bcb7eb9a504f0958630b5469f7929c8f"},"schema_version":"1.0"},"canonical_sha256":"bb960fc9defd1e62b647fc450ce5494ffb7eec27195389b6ff0cc6626319da5e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:07:16.707565Z","signature_b64":"dG6WQQ2baBJ81bK8/QNSZDcPliTj8Evpulei+E9tUr5/NbIoWZcmpmKOuuHhCSU9kmImfDeQIXC92RmR9ly+Cw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"bb960fc9defd1e62b647fc450ce5494ffb7eec27195389b6ff0cc6626319da5e","last_reissued_at":"2026-07-05T11:07:16.707076Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:07:16.707076Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2411.12944","source_version":4,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:07:16Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Ijbb+7NhCURrLjIglbe/n6T2+6KR1wjTaWPLBx60edCufEbXAmHh2aF6waNpO+vhuvYuEuHuZ9YGWy7iw8NiBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-14T10:47:21.667940Z"},"content_sha256":"821539c74c034be363cce523ed764845abd908a0cf8d4864ea699dd1441b799b","schema_version":"1.0","event_id":"sha256:821539c74c034be363cce523ed764845abd908a0cf8d4864ea699dd1441b799b"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:XOLA7SO67UPGFNSH7RCQZZKJJ7","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"From Estimands to Robust Inference of Treatment Effects in Platform Trials","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Gregory Levin, Jun Shao, Nicole Mayer-Hamblett, Patrick J. Heagerty, Ting Ye, Yanyao Yi, Yifan Yi, Yuhan Qian","submitted_at":"2024-11-20T00:28:36Z","abstract_excerpt":"A platform trial is an innovative clinical trial design that uses a master protocol to evaluate multiple treatments, where patients are often assigned to different subsets of treatment arms based on individual characteristics, enrollment timing, and treatment availability. While offering increased flexibility, this constrained and non-uniform treatment assignment poses inferential challenges, with two fundamental ones being the precise definition of treatment effects and robust, efficient inference on these effects. Such challenges arise primarily because some commonly used analysis approaches"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2411.12944","kind":"arxiv","version":4},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2411.12944/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:07:16Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ay4xyd7k7JycDyLeK4U6cmdwU/5NmR9hwZ/oxAsb4iZKDvsDqH1a6GzhRpovpc8GRhnbhek9/WeCdbzTXBd+Cg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-14T10:47:21.668325Z"},"content_sha256":"1a247b897c542371c804c12bedc6dd2692baa8841a530ebb28a7042956fb895c","schema_version":"1.0","event_id":"sha256:1a247b897c542371c804c12bedc6dd2692baa8841a530ebb28a7042956fb895c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/XOLA7SO67UPGFNSH7RCQZZKJJ7/bundle.json","state_url":"https://pith.science/pith/XOLA7SO67UPGFNSH7RCQZZKJJ7/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/XOLA7SO67UPGFNSH7RCQZZKJJ7/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-14T10:47:21Z","links":{"resolver":"https://pith.science/pith/XOLA7SO67UPGFNSH7RCQZZKJJ7","bundle":"https://pith.science/pith/XOLA7SO67UPGFNSH7RCQZZKJJ7/bundle.json","state":"https://pith.science/pith/XOLA7SO67UPGFNSH7RCQZZKJJ7/state.json","well_known_bundle":"https://pith.science/.well-known/pith/XOLA7SO67UPGFNSH7RCQZZKJJ7/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:XOLA7SO67UPGFNSH7RCQZZKJJ7","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e43007cecf27cf19d4d30c24b3ac7e32bcb7eb9a504f0958630b5469f7929c8f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2024-11-20T00:28:36Z","title_canon_sha256":"d4a6411674574af9659ead64ec28ea7d667440109d6faf80af897123062f4a32"},"schema_version":"1.0","source":{"id":"2411.12944","kind":"arxiv","version":4}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2411.12944","created_at":"2026-07-05T11:07:16Z"},{"alias_kind":"arxiv_version","alias_value":"2411.12944v4","created_at":"2026-07-05T11:07:16Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2411.12944","created_at":"2026-07-05T11:07:16Z"},{"alias_kind":"pith_short_12","alias_value":"XOLA7SO67UPG","created_at":"2026-07-05T11:07:16Z"},{"alias_kind":"pith_short_16","alias_value":"XOLA7SO67UPGFNSH","created_at":"2026-07-05T11:07:16Z"},{"alias_kind":"pith_short_8","alias_value":"XOLA7SO6","created_at":"2026-07-05T11:07:16Z"}],"graph_snapshots":[{"event_id":"sha256:1a247b897c542371c804c12bedc6dd2692baa8841a530ebb28a7042956fb895c","target":"graph","created_at":"2026-07-05T11:07:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2411.12944/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"A platform trial is an innovative clinical trial design that uses a master protocol to evaluate multiple treatments, where patients are often assigned to different subsets of treatment arms based on individual characteristics, enrollment timing, and treatment availability. While offering increased flexibility, this constrained and non-uniform treatment assignment poses inferential challenges, with two fundamental ones being the precise definition of treatment effects and robust, efficient inference on these effects. Such challenges arise primarily because some commonly used analysis approaches","authors_text":"Gregory Levin, Jun Shao, Nicole Mayer-Hamblett, Patrick J. Heagerty, Ting Ye, Yanyao Yi, Yifan Yi, Yuhan Qian","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2024-11-20T00:28:36Z","title":"From Estimands to Robust Inference of Treatment Effects in Platform Trials"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2411.12944","kind":"arxiv","version":4},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:821539c74c034be363cce523ed764845abd908a0cf8d4864ea699dd1441b799b","target":"record","created_at":"2026-07-05T11:07:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e43007cecf27cf19d4d30c24b3ac7e32bcb7eb9a504f0958630b5469f7929c8f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2024-11-20T00:28:36Z","title_canon_sha256":"d4a6411674574af9659ead64ec28ea7d667440109d6faf80af897123062f4a32"},"schema_version":"1.0","source":{"id":"2411.12944","kind":"arxiv","version":4}},"canonical_sha256":"bb960fc9defd1e62b647fc450ce5494ffb7eec27195389b6ff0cc6626319da5e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"bb960fc9defd1e62b647fc450ce5494ffb7eec27195389b6ff0cc6626319da5e","first_computed_at":"2026-07-05T11:07:16.707076Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:07:16.707076Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"dG6WQQ2baBJ81bK8/QNSZDcPliTj8Evpulei+E9tUr5/NbIoWZcmpmKOuuHhCSU9kmImfDeQIXC92RmR9ly+Cw==","signature_status":"signed_v1","signed_at":"2026-07-05T11:07:16.707565Z","signed_message":"canonical_sha256_bytes"},"source_id":"2411.12944","source_kind":"arxiv","source_version":4}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:821539c74c034be363cce523ed764845abd908a0cf8d4864ea699dd1441b799b","sha256:1a247b897c542371c804c12bedc6dd2692baa8841a530ebb28a7042956fb895c"],"state_sha256":"711387b59e37fcd26b4ae14b8aad5feb24267861fbbd5aca66539d980e128c53"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"NXs1cG/ms5HvvDdGpo1qrtYakgHbhsFuxo14z97VQTmYPI80f2cof945BBklpUGH0wlTRHHGoZyadS+N3V5KDw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-14T10:47:21.671527Z","bundle_sha256":"cc6ebec9b275869e399c46066aa12dd83e76bc473042cebb888cd91a35844ec0"}}