{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:XOYIW3G7USYHEQ4EVIQBXTUY7O","short_pith_number":"pith:XOYIW3G7","canonical_record":{"source":{"id":"1508.02601","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-08-11T14:05:36Z","cross_cats_sorted":[],"title_canon_sha256":"344be27a453ac83fb1fb4450a00680d6ed1219f355e9b2a0c587302d0feab927","abstract_canon_sha256":"f5796677c75fa6df287177f0e795d398ea8f8669a592fc4b20ef09bb2faa0e6e"},"schema_version":"1.0"},"canonical_sha256":"bbb08b6cdfa4b0724384aa201bce98fbbf1c5a905b6e68cb45e29fed27966fe6","source":{"kind":"arxiv","id":"1508.02601","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1508.02601","created_at":"2026-05-18T01:06:24Z"},{"alias_kind":"arxiv_version","alias_value":"1508.02601v2","created_at":"2026-05-18T01:06:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1508.02601","created_at":"2026-05-18T01:06:24Z"},{"alias_kind":"pith_short_12","alias_value":"XOYIW3G7USYH","created_at":"2026-05-18T12:29:50Z"},{"alias_kind":"pith_short_16","alias_value":"XOYIW3G7USYHEQ4E","created_at":"2026-05-18T12:29:50Z"},{"alias_kind":"pith_short_8","alias_value":"XOYIW3G7","created_at":"2026-05-18T12:29:50Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:XOYIW3G7USYHEQ4EVIQBXTUY7O","target":"record","payload":{"canonical_record":{"source":{"id":"1508.02601","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-08-11T14:05:36Z","cross_cats_sorted":[],"title_canon_sha256":"344be27a453ac83fb1fb4450a00680d6ed1219f355e9b2a0c587302d0feab927","abstract_canon_sha256":"f5796677c75fa6df287177f0e795d398ea8f8669a592fc4b20ef09bb2faa0e6e"},"schema_version":"1.0"},"canonical_sha256":"bbb08b6cdfa4b0724384aa201bce98fbbf1c5a905b6e68cb45e29fed27966fe6","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:06:24.619769Z","signature_b64":"Ul2KZ9YlOSuiPhSrJRt3eR/y3rH09GuIeac8NkwaSqmzhDLXFY3eGRjpua6bIB7/iQuIImlVuN3IGJdqmcUgDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"bbb08b6cdfa4b0724384aa201bce98fbbf1c5a905b6e68cb45e29fed27966fe6","last_reissued_at":"2026-05-18T01:06:24.619350Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:06:24.619350Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1508.02601","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:06:24Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"K3hrbFUuuZYdQi+zf2gPs6l+vMenx7zSBiRMYMEMq7/6FHKfHqyhqyyz9MlV4R0RYhSbTHQr+s7scvwtIYqbAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-30T11:39:25.189421Z"},"content_sha256":"5ed564a164cc1c64922826faba1259768ba56b2aadf9ec92a100b7d563fb8805","schema_version":"1.0","event_id":"sha256:5ed564a164cc1c64922826faba1259768ba56b2aadf9ec92a100b7d563fb8805"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:XOYIW3G7USYHEQ4EVIQBXTUY7O","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"mRNA-miRNA Reciprocal Regulation Enabled Bistable Switch Directs Cell Fate Decision","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Hang Zhang, Jianhua Xing, Jingyu Zhang, Xiao-Jun Tian","submitted_at":"2015-08-11T14:05:36Z","abstract_excerpt":"miRNAs serve as crucial post-transcriptional regulators in various essential cell fate decision. However, the contribution of the mRNA-miRNA mutual regulation to bistability is not fully understood. Here, we built a set of mathematical models of mRNA-miRNA interactions and systematically analyzed the sensitivity of response curves under various conditions. First, we found that mRNA-miRNA reciprocal regulation could manifest ultrasensitivity to subserve the generation of bistability when equipped with a positive feedback loop. Second, the region of bistability is expanded by a stronger competin"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1508.02601","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:06:24Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"P/K28jUWbpEMbu8qcE3POl6gNjXn2np0vNTzdO2YRyJqIyo9jnIQr+y3vbRRTYu302xiQ4MNZATziRRpMPTOAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-30T11:39:25.190113Z"},"content_sha256":"453a8b7ea0f8a8ffcceb69315f68e1388e2e3e43ee0c6fc8249a5817f6639725","schema_version":"1.0","event_id":"sha256:453a8b7ea0f8a8ffcceb69315f68e1388e2e3e43ee0c6fc8249a5817f6639725"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/XOYIW3G7USYHEQ4EVIQBXTUY7O/bundle.json","state_url":"https://pith.science/pith/XOYIW3G7USYHEQ4EVIQBXTUY7O/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/XOYIW3G7USYHEQ4EVIQBXTUY7O/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-30T11:39:25Z","links":{"resolver":"https://pith.science/pith/XOYIW3G7USYHEQ4EVIQBXTUY7O","bundle":"https://pith.science/pith/XOYIW3G7USYHEQ4EVIQBXTUY7O/bundle.json","state":"https://pith.science/pith/XOYIW3G7USYHEQ4EVIQBXTUY7O/state.json","well_known_bundle":"https://pith.science/.well-known/pith/XOYIW3G7USYHEQ4EVIQBXTUY7O/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:XOYIW3G7USYHEQ4EVIQBXTUY7O","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f5796677c75fa6df287177f0e795d398ea8f8669a592fc4b20ef09bb2faa0e6e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-08-11T14:05:36Z","title_canon_sha256":"344be27a453ac83fb1fb4450a00680d6ed1219f355e9b2a0c587302d0feab927"},"schema_version":"1.0","source":{"id":"1508.02601","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1508.02601","created_at":"2026-05-18T01:06:24Z"},{"alias_kind":"arxiv_version","alias_value":"1508.02601v2","created_at":"2026-05-18T01:06:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1508.02601","created_at":"2026-05-18T01:06:24Z"},{"alias_kind":"pith_short_12","alias_value":"XOYIW3G7USYH","created_at":"2026-05-18T12:29:50Z"},{"alias_kind":"pith_short_16","alias_value":"XOYIW3G7USYHEQ4E","created_at":"2026-05-18T12:29:50Z"},{"alias_kind":"pith_short_8","alias_value":"XOYIW3G7","created_at":"2026-05-18T12:29:50Z"}],"graph_snapshots":[{"event_id":"sha256:453a8b7ea0f8a8ffcceb69315f68e1388e2e3e43ee0c6fc8249a5817f6639725","target":"graph","created_at":"2026-05-18T01:06:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"miRNAs serve as crucial post-transcriptional regulators in various essential cell fate decision. However, the contribution of the mRNA-miRNA mutual regulation to bistability is not fully understood. Here, we built a set of mathematical models of mRNA-miRNA interactions and systematically analyzed the sensitivity of response curves under various conditions. First, we found that mRNA-miRNA reciprocal regulation could manifest ultrasensitivity to subserve the generation of bistability when equipped with a positive feedback loop. Second, the region of bistability is expanded by a stronger competin","authors_text":"Hang Zhang, Jianhua Xing, Jingyu Zhang, Xiao-Jun Tian","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-08-11T14:05:36Z","title":"mRNA-miRNA Reciprocal Regulation Enabled Bistable Switch Directs Cell Fate Decision"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1508.02601","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:5ed564a164cc1c64922826faba1259768ba56b2aadf9ec92a100b7d563fb8805","target":"record","created_at":"2026-05-18T01:06:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f5796677c75fa6df287177f0e795d398ea8f8669a592fc4b20ef09bb2faa0e6e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-08-11T14:05:36Z","title_canon_sha256":"344be27a453ac83fb1fb4450a00680d6ed1219f355e9b2a0c587302d0feab927"},"schema_version":"1.0","source":{"id":"1508.02601","kind":"arxiv","version":2}},"canonical_sha256":"bbb08b6cdfa4b0724384aa201bce98fbbf1c5a905b6e68cb45e29fed27966fe6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"bbb08b6cdfa4b0724384aa201bce98fbbf1c5a905b6e68cb45e29fed27966fe6","first_computed_at":"2026-05-18T01:06:24.619350Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:06:24.619350Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Ul2KZ9YlOSuiPhSrJRt3eR/y3rH09GuIeac8NkwaSqmzhDLXFY3eGRjpua6bIB7/iQuIImlVuN3IGJdqmcUgDQ==","signature_status":"signed_v1","signed_at":"2026-05-18T01:06:24.619769Z","signed_message":"canonical_sha256_bytes"},"source_id":"1508.02601","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:5ed564a164cc1c64922826faba1259768ba56b2aadf9ec92a100b7d563fb8805","sha256:453a8b7ea0f8a8ffcceb69315f68e1388e2e3e43ee0c6fc8249a5817f6639725"],"state_sha256":"02d5d3dd778014baf73dd835a39bfefdaaf0263347a8828ab8f8bc78701d9ae2"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kows1CsOi8tmBZFHxrbTUOnSC8dfWqm9IGG5cNioKvWmRr2g0n31zS3fKxGx7KhH1NFz5DxBzHLCa7+6lAdtBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-30T11:39:25.193869Z","bundle_sha256":"27a73a2a8742b5b872165583672d43bac46a2c2081cd3d524f4418a4047135ff"}}