{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:XZ42JXLXXXS4SCXJAZHQYP6PKM","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0eb24d264e7fd3959f9ef8062176ce16a2f086df4fe23212b401a9fd683302f9","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.app-ph","submitted_at":"2019-04-21T22:48:53Z","title_canon_sha256":"8d1fc7a957f75156a52e8eaeef5be7b9d1ecc09769e7409553ab7686edb20c71"},"schema_version":"1.0","source":{"id":"1904.09672","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1904.09672","created_at":"2026-05-17T23:48:03Z"},{"alias_kind":"arxiv_version","alias_value":"1904.09672v1","created_at":"2026-05-17T23:48:03Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1904.09672","created_at":"2026-05-17T23:48:03Z"},{"alias_kind":"pith_short_12","alias_value":"XZ42JXLXXXS4","created_at":"2026-05-18T12:33:33Z"},{"alias_kind":"pith_short_16","alias_value":"XZ42JXLXXXS4SCXJ","created_at":"2026-05-18T12:33:33Z"},{"alias_kind":"pith_short_8","alias_value":"XZ42JXLX","created_at":"2026-05-18T12:33:33Z"}],"graph_snapshots":[{"event_id":"sha256:4cba81d51c78fece28668e4cba8bfb397045c846856b5cec8901b9199b1c2bf4","target":"graph","created_at":"2026-05-17T23:48:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We report the design and development of a dual-functional magnetic nanoparticle platform for potential treatment of H. pylori infection. We show that an ultralow concentration of Mn0.3Fe2.7O4@SiO2 nanoparticles subjected to a moderate AC magnetic field, without bulk heating effect, can deposit heat locally and effectively inhibit H. pylori growth and virulence in vitro. When coupled with antibiotic amoxicillin, the dual-functional amoxicillin loaded Mn0.3Fe2.7O4@SiO2 further decreases the bacteria survival rate by a factor of 7 and 5, respectively, compared to amoxicillin treatment and nanopar","authors_text":"Gangshi Wang, Hao Zeng, Jianwei Liu, Jing Liu, Lichen Wang, Ling Ye, Meiliang Gong, Shuli He, Tao Wu, Xiang Yu, Yaping Xu, Yunjuan Lin","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.app-ph","submitted_at":"2019-04-21T22:48:53Z","title":"Synergistic Effects of Nanoparticle Heating and Amoxicillin on H. Pylori Inhibition"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1904.09672","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:0aa171828560bb4f00ad229a9a17b762c00d5c0f2f47c961059295d67945025f","target":"record","created_at":"2026-05-17T23:48:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0eb24d264e7fd3959f9ef8062176ce16a2f086df4fe23212b401a9fd683302f9","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.app-ph","submitted_at":"2019-04-21T22:48:53Z","title_canon_sha256":"8d1fc7a957f75156a52e8eaeef5be7b9d1ecc09769e7409553ab7686edb20c71"},"schema_version":"1.0","source":{"id":"1904.09672","kind":"arxiv","version":1}},"canonical_sha256":"be79a4dd77bde5c90ae9064f0c3fcf53369ddc8362a8b218ffe487ae636c2fb5","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"be79a4dd77bde5c90ae9064f0c3fcf53369ddc8362a8b218ffe487ae636c2fb5","first_computed_at":"2026-05-17T23:48:03.671291Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:48:03.671291Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"HHYN1iw598hN+2sWZ23RA4fUc2b5JzYan9LjM2clHctWBOwO58IcW9S081CGJtMNhoJGXLPXIBM6hnESGB5DDg==","signature_status":"signed_v1","signed_at":"2026-05-17T23:48:03.671705Z","signed_message":"canonical_sha256_bytes"},"source_id":"1904.09672","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:0aa171828560bb4f00ad229a9a17b762c00d5c0f2f47c961059295d67945025f","sha256:4cba81d51c78fece28668e4cba8bfb397045c846856b5cec8901b9199b1c2bf4"],"state_sha256":"f3fe1e5c941f65d6190cd1b6c989c6c56863b588327e5906a90402be3384c7c4"}