{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:Y4RC7XBVH5UY6EFKBOCDMAL3XS","short_pith_number":"pith:Y4RC7XBV","canonical_record":{"source":{"id":"2606.01051","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-05-31T06:46:26Z","cross_cats_sorted":[],"title_canon_sha256":"c7c858a53a071987418cd0bfd52361a6dae89f2725505ecdb1d2ce099cfed684","abstract_canon_sha256":"10bb9444b962d0175e6a0caffc668edc92e944a9ec310c766c16082cb13a46ef"},"schema_version":"1.0"},"canonical_sha256":"c7222fdc353f698f10aa0b8436017bbc81d7ae1f05e07c435e9031c2bab54123","source":{"kind":"arxiv","id":"2606.01051","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.01051","created_at":"2026-06-02T01:04:19Z"},{"alias_kind":"arxiv_version","alias_value":"2606.01051v1","created_at":"2026-06-02T01:04:19Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.01051","created_at":"2026-06-02T01:04:19Z"},{"alias_kind":"pith_short_12","alias_value":"Y4RC7XBVH5UY","created_at":"2026-06-02T01:04:19Z"},{"alias_kind":"pith_short_16","alias_value":"Y4RC7XBVH5UY6EFK","created_at":"2026-06-02T01:04:19Z"},{"alias_kind":"pith_short_8","alias_value":"Y4RC7XBV","created_at":"2026-06-02T01:04:19Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:Y4RC7XBVH5UY6EFKBOCDMAL3XS","target":"record","payload":{"canonical_record":{"source":{"id":"2606.01051","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-05-31T06:46:26Z","cross_cats_sorted":[],"title_canon_sha256":"c7c858a53a071987418cd0bfd52361a6dae89f2725505ecdb1d2ce099cfed684","abstract_canon_sha256":"10bb9444b962d0175e6a0caffc668edc92e944a9ec310c766c16082cb13a46ef"},"schema_version":"1.0"},"canonical_sha256":"c7222fdc353f698f10aa0b8436017bbc81d7ae1f05e07c435e9031c2bab54123","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-02T01:04:19.813265Z","signature_b64":"Q0LLX56Kc5RdaVvPdt2T7XS2NDOFukmbCeOz5oWx/RTTPiVSK/PrY+8wbZfm0natry8I/2gf4ybX18ArNalnAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"c7222fdc353f698f10aa0b8436017bbc81d7ae1f05e07c435e9031c2bab54123","last_reissued_at":"2026-06-02T01:04:19.812830Z","signature_status":"signed_v1","first_computed_at":"2026-06-02T01:04:19.812830Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2606.01051","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-02T01:04:19Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"vB1UVNmQWNDxm+fFExxNmTFMsImIYG/UgSfjBDQkCxckucLEVMA2P3rqWE/rh/M/tPnpHMcXkYac0mcKfrGFCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T01:56:45.081353Z"},"content_sha256":"28ad554805afc676a209a2ae13cdf5abcdc663ce7c1ad9c09a2930dcab96a4ed","schema_version":"1.0","event_id":"sha256:28ad554805afc676a209a2ae13cdf5abcdc663ce7c1ad9c09a2930dcab96a4ed"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:Y4RC7XBVH5UY6EFKBOCDMAL3XS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Interaction-Limited Safe Continuous-Time RL for Dynamical Medical Treatment","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"cs.LG","authors_text":"Akifumi Wachi, Katsuki Fujisawa, Kenji Wakabayashi, Ken Kawano, Kyoung-Sook Kim, Mehrshad Sadria, Mengmou Li, Richard Weiss, Sebastien Gros, Xiao Hu, Xin Liu, Xun Shen, Ying Chen, Yongqi Zhou, Yoshihiko Fujisawa, Yuepeng Wang","submitted_at":"2026-05-31T06:46:26Z","abstract_excerpt":"Dynamic medical treatment requires deciding treatment intensity and intervention timing, while patient states evolve continuously and adverse events may occur between clinical interactions. Most existing treatment learning methods assume fixed schedules or enforce safety only at discrete decision points. We propose Interaction-Limited Safe Continuous-Time Reinforcement Learning, a framework that jointly optimizes treatment administration and clinical interaction timing under trajectory-level safety constraints. Our key idea is to reformulate the continuous time treatment problem as an option-b"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.01051","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.01051/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-02T01:04:19Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"c5MnytnvaN1cWIArOnTpUiY2HdAqhP8Ezc0CcLq2fM0yLym4PrjG0F2AdyMO/Dw+rexPXxvfTv8bcBa1MmQTDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T01:56:45.081767Z"},"content_sha256":"46f30ccc6f681dfa5862810edbe49f6e4a45c95b29dec985a3ff90d6b02d66d4","schema_version":"1.0","event_id":"sha256:46f30ccc6f681dfa5862810edbe49f6e4a45c95b29dec985a3ff90d6b02d66d4"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/Y4RC7XBVH5UY6EFKBOCDMAL3XS/bundle.json","state_url":"https://pith.science/pith/Y4RC7XBVH5UY6EFKBOCDMAL3XS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/Y4RC7XBVH5UY6EFKBOCDMAL3XS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-09T01:56:45Z","links":{"resolver":"https://pith.science/pith/Y4RC7XBVH5UY6EFKBOCDMAL3XS","bundle":"https://pith.science/pith/Y4RC7XBVH5UY6EFKBOCDMAL3XS/bundle.json","state":"https://pith.science/pith/Y4RC7XBVH5UY6EFKBOCDMAL3XS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/Y4RC7XBVH5UY6EFKBOCDMAL3XS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:Y4RC7XBVH5UY6EFKBOCDMAL3XS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"10bb9444b962d0175e6a0caffc668edc92e944a9ec310c766c16082cb13a46ef","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-05-31T06:46:26Z","title_canon_sha256":"c7c858a53a071987418cd0bfd52361a6dae89f2725505ecdb1d2ce099cfed684"},"schema_version":"1.0","source":{"id":"2606.01051","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.01051","created_at":"2026-06-02T01:04:19Z"},{"alias_kind":"arxiv_version","alias_value":"2606.01051v1","created_at":"2026-06-02T01:04:19Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.01051","created_at":"2026-06-02T01:04:19Z"},{"alias_kind":"pith_short_12","alias_value":"Y4RC7XBVH5UY","created_at":"2026-06-02T01:04:19Z"},{"alias_kind":"pith_short_16","alias_value":"Y4RC7XBVH5UY6EFK","created_at":"2026-06-02T01:04:19Z"},{"alias_kind":"pith_short_8","alias_value":"Y4RC7XBV","created_at":"2026-06-02T01:04:19Z"}],"graph_snapshots":[{"event_id":"sha256:46f30ccc6f681dfa5862810edbe49f6e4a45c95b29dec985a3ff90d6b02d66d4","target":"graph","created_at":"2026-06-02T01:04:19Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.01051/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Dynamic medical treatment requires deciding treatment intensity and intervention timing, while patient states evolve continuously and adverse events may occur between clinical interactions. Most existing treatment learning methods assume fixed schedules or enforce safety only at discrete decision points. We propose Interaction-Limited Safe Continuous-Time Reinforcement Learning, a framework that jointly optimizes treatment administration and clinical interaction timing under trajectory-level safety constraints. Our key idea is to reformulate the continuous time treatment problem as an option-b","authors_text":"Akifumi Wachi, Katsuki Fujisawa, Kenji Wakabayashi, Ken Kawano, Kyoung-Sook Kim, Mehrshad Sadria, Mengmou Li, Richard Weiss, Sebastien Gros, Xiao Hu, Xin Liu, Xun Shen, Ying Chen, Yongqi Zhou, Yoshihiko Fujisawa, Yuepeng Wang","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-05-31T06:46:26Z","title":"Interaction-Limited Safe Continuous-Time RL for Dynamical Medical Treatment"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.01051","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:28ad554805afc676a209a2ae13cdf5abcdc663ce7c1ad9c09a2930dcab96a4ed","target":"record","created_at":"2026-06-02T01:04:19Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"10bb9444b962d0175e6a0caffc668edc92e944a9ec310c766c16082cb13a46ef","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-05-31T06:46:26Z","title_canon_sha256":"c7c858a53a071987418cd0bfd52361a6dae89f2725505ecdb1d2ce099cfed684"},"schema_version":"1.0","source":{"id":"2606.01051","kind":"arxiv","version":1}},"canonical_sha256":"c7222fdc353f698f10aa0b8436017bbc81d7ae1f05e07c435e9031c2bab54123","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"c7222fdc353f698f10aa0b8436017bbc81d7ae1f05e07c435e9031c2bab54123","first_computed_at":"2026-06-02T01:04:19.812830Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-02T01:04:19.812830Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Q0LLX56Kc5RdaVvPdt2T7XS2NDOFukmbCeOz5oWx/RTTPiVSK/PrY+8wbZfm0natry8I/2gf4ybX18ArNalnAA==","signature_status":"signed_v1","signed_at":"2026-06-02T01:04:19.813265Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.01051","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:28ad554805afc676a209a2ae13cdf5abcdc663ce7c1ad9c09a2930dcab96a4ed","sha256:46f30ccc6f681dfa5862810edbe49f6e4a45c95b29dec985a3ff90d6b02d66d4"],"state_sha256":"1b33eac1d6ef29403125d8401ef72c74419b8e259b7fc25d00d046c9cdcc7b6c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"I/8r6+LLQk/5QZYcdLXI82rNfnkvCGU0BT19M0z+wXVkUE1IBZoQzZ0/ufDdg+y1Nfb+reXYlm6ghPsOINqIBA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-09T01:56:45.085272Z","bundle_sha256":"f997b1fad8379bb252fc7f3030971fbb02b78c7196be069d3e97bfc68f061ceb"}}