{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2023:Y7CCYFUXP3LDIDX5RCNGULHNPQ","short_pith_number":"pith:Y7CCYFUX","schema_version":"1.0","canonical_sha256":"c7c42c16977ed6340efd889a6a2ced7c3876fd85c3697c692b69e27b9f1b0465","source":{"kind":"arxiv","id":"2304.12391","version":2},"attestation_state":"computed","paper":{"title":"A Likelihood Perspective on Dose-Finding Study Designs in Oncology","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Zhiwei Zhang","submitted_at":"2023-04-24T18:38:51Z","abstract_excerpt":"Dose-finding studies in oncology often include an up-and-down dose transition rule that assigns a dose to each cohort of patients based on accumulating data on dose-limiting toxicity (DLT) events. In making a dose transition decision, a key scientific question is whether the true DLT rate of the current dose exceeds the target DLT rate, and the statistical question is how to evaluate the statistical evidence in the available DLT data with respect to that scientific question. This article introduces generalized likelihood ratios (GLRs) that can be used to measure statistical evidence and suppor"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2304.12391","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2023-04-24T18:38:51Z","cross_cats_sorted":[],"title_canon_sha256":"874ea64639cb78fd0a3c3b869d83bcc3f101546357aada5303681657f56ef7d8","abstract_canon_sha256":"ea2c968423194a120d7b007d011c2e40c175b12b8e1cb518e1dd27ef89750552"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T10:06:37.105355Z","signature_b64":"T4+AgcqpQX71/Sg/IdKGY0nDnishBG2LkluDrpyFgXgDNdazUN0hVERi00Tdb1CpC7emJt9XPerrA+ASTXrkCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"c7c42c16977ed6340efd889a6a2ced7c3876fd85c3697c692b69e27b9f1b0465","last_reissued_at":"2026-07-05T10:06:37.104975Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T10:06:37.104975Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"A Likelihood Perspective on Dose-Finding Study Designs in Oncology","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Zhiwei Zhang","submitted_at":"2023-04-24T18:38:51Z","abstract_excerpt":"Dose-finding studies in oncology often include an up-and-down dose transition rule that assigns a dose to each cohort of patients based on accumulating data on dose-limiting toxicity (DLT) events. In making a dose transition decision, a key scientific question is whether the true DLT rate of the current dose exceeds the target DLT rate, and the statistical question is how to evaluate the statistical evidence in the available DLT data with respect to that scientific question. This article introduces generalized likelihood ratios (GLRs) that can be used to measure statistical evidence and suppor"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2304.12391","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2304.12391/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2304.12391","created_at":"2026-07-05T10:06:37.105026+00:00"},{"alias_kind":"arxiv_version","alias_value":"2304.12391v2","created_at":"2026-07-05T10:06:37.105026+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2304.12391","created_at":"2026-07-05T10:06:37.105026+00:00"},{"alias_kind":"pith_short_12","alias_value":"Y7CCYFUXP3LD","created_at":"2026-07-05T10:06:37.105026+00:00"},{"alias_kind":"pith_short_16","alias_value":"Y7CCYFUXP3LDIDX5","created_at":"2026-07-05T10:06:37.105026+00:00"},{"alias_kind":"pith_short_8","alias_value":"Y7CCYFUX","created_at":"2026-07-05T10:06:37.105026+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/Y7CCYFUXP3LDIDX5RCNGULHNPQ","json":"https://pith.science/pith/Y7CCYFUXP3LDIDX5RCNGULHNPQ.json","graph_json":"https://pith.science/api/pith-number/Y7CCYFUXP3LDIDX5RCNGULHNPQ/graph.json","events_json":"https://pith.science/api/pith-number/Y7CCYFUXP3LDIDX5RCNGULHNPQ/events.json","paper":"https://pith.science/paper/Y7CCYFUX"},"agent_actions":{"view_html":"https://pith.science/pith/Y7CCYFUXP3LDIDX5RCNGULHNPQ","download_json":"https://pith.science/pith/Y7CCYFUXP3LDIDX5RCNGULHNPQ.json","view_paper":"https://pith.science/paper/Y7CCYFUX","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2304.12391&json=true","fetch_graph":"https://pith.science/api/pith-number/Y7CCYFUXP3LDIDX5RCNGULHNPQ/graph.json","fetch_events":"https://pith.science/api/pith-number/Y7CCYFUXP3LDIDX5RCNGULHNPQ/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/Y7CCYFUXP3LDIDX5RCNGULHNPQ/action/timestamp_anchor","attest_storage":"https://pith.science/pith/Y7CCYFUXP3LDIDX5RCNGULHNPQ/action/storage_attestation","attest_author":"https://pith.science/pith/Y7CCYFUXP3LDIDX5RCNGULHNPQ/action/author_attestation","sign_citation":"https://pith.science/pith/Y7CCYFUXP3LDIDX5RCNGULHNPQ/action/citation_signature","submit_replication":"https://pith.science/pith/Y7CCYFUXP3LDIDX5RCNGULHNPQ/action/replication_record"}},"created_at":"2026-07-05T10:06:37.105026+00:00","updated_at":"2026-07-05T10:06:37.105026+00:00"}