{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:YFD7SB75BINKTAKMJBS7G6CGX2","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"80ed0daa660af91ea5071f70a4ae72c881835886b8ebed382641b92dff76d7f9","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2026-07-01T15:57:19Z","title_canon_sha256":"4500c90a27e03a5f484266cbeb18d0dc081ea5126b708d846444915ee3e7ccf1"},"schema_version":"1.0","source":{"id":"2607.01105","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2607.01105","created_at":"2026-07-02T01:18:29Z"},{"alias_kind":"arxiv_version","alias_value":"2607.01105v1","created_at":"2026-07-02T01:18:29Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2607.01105","created_at":"2026-07-02T01:18:29Z"},{"alias_kind":"pith_short_12","alias_value":"YFD7SB75BINK","created_at":"2026-07-02T01:18:29Z"},{"alias_kind":"pith_short_16","alias_value":"YFD7SB75BINKTAKM","created_at":"2026-07-02T01:18:29Z"},{"alias_kind":"pith_short_8","alias_value":"YFD7SB75","created_at":"2026-07-02T01:18:29Z"}],"graph_snapshots":[{"event_id":"sha256:0775cdca50cc001d31e9e6f0575f61a72022624e7a7524b0c06866ff233ca418","target":"graph","created_at":"2026-07-02T01:18:29Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2607.01105/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"We present SynLaD, a latent diffusion framework for small-molecule generation that unifies ligand-based drug design objectives (what to make) with synthetic accessibility (how to make it). Current models typically optimize one objective at the expense of the other, creating a bottleneck for discovering high-scoring and synthesizable molecules. SynLaD combines reaction-constrained generation with pharmacophore-conditioned 3D design by learning a latent space that decodes to both 3D structures and synthesis pathways. An encoder maps molecules to a latent representation used by two decoder heads:","authors_text":"Colin Grambow, John Bradshaw, Kangway Chuang, Kirill Shmilovich, Miruna Cretu, Omar Mahmood, Patricia Suriana, Saeed Saremi, Vishnu Sresht","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2026-07-01T15:57:19Z","title":"SynLaD: Latent Diffusion for Generating Synthesizable Molecules Conditioned on 3D Pharmacophore Profiles"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.01105","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:327dcf4b5db01a9949a4621ff431c6b10bb8dc814986c5d763abe7618e60f434","target":"record","created_at":"2026-07-02T01:18:29Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"80ed0daa660af91ea5071f70a4ae72c881835886b8ebed382641b92dff76d7f9","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2026-07-01T15:57:19Z","title_canon_sha256":"4500c90a27e03a5f484266cbeb18d0dc081ea5126b708d846444915ee3e7ccf1"},"schema_version":"1.0","source":{"id":"2607.01105","kind":"arxiv","version":1}},"canonical_sha256":"c147f907fd0a1aa9814c4865f37846be93e4dc91e209dd28777513c1176404a6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"c147f907fd0a1aa9814c4865f37846be93e4dc91e209dd28777513c1176404a6","first_computed_at":"2026-07-02T01:18:29.228385Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-02T01:18:29.228385Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"nUsX5iRvNJiLGEyc6Sde0+9i8Pieecr0fRG7NrWhBC0iwJQeqzuipWsDvC+1nqEhH1tOnl8D5IsUIWVt4ID0Bw==","signature_status":"signed_v1","signed_at":"2026-07-02T01:18:29.228760Z","signed_message":"canonical_sha256_bytes"},"source_id":"2607.01105","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:327dcf4b5db01a9949a4621ff431c6b10bb8dc814986c5d763abe7618e60f434","sha256:0775cdca50cc001d31e9e6f0575f61a72022624e7a7524b0c06866ff233ca418"],"state_sha256":"f6147ecfcd5d589ccdf39b197415702e257074936adc274a42b3f2b584c02628"}