{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:YFX7OTN2EAPUQ3ZU35CLWNZ42N","short_pith_number":"pith:YFX7OTN2","canonical_record":{"source":{"id":"1305.7478","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2013-05-31T16:26:14Z","cross_cats_sorted":["q-bio.PE"],"title_canon_sha256":"ab737d8cdd83b64cdc184860470e24c9b6fef708e857837ce94369182f1c94f6","abstract_canon_sha256":"91e2d88f9bfb9ad8f7039d7dcff513994101ce96023357dcd73cee052c56aefc"},"schema_version":"1.0"},"canonical_sha256":"c16ff74dba201f486f34df44bb373cd35d3a3873df8dd5a0c1fbaabc57b256a5","source":{"kind":"arxiv","id":"1305.7478","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1305.7478","created_at":"2026-05-18T03:20:08Z"},{"alias_kind":"arxiv_version","alias_value":"1305.7478v2","created_at":"2026-05-18T03:20:08Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1305.7478","created_at":"2026-05-18T03:20:08Z"},{"alias_kind":"pith_short_12","alias_value":"YFX7OTN2EAPU","created_at":"2026-05-18T12:28:06Z"},{"alias_kind":"pith_short_16","alias_value":"YFX7OTN2EAPUQ3ZU","created_at":"2026-05-18T12:28:06Z"},{"alias_kind":"pith_short_8","alias_value":"YFX7OTN2","created_at":"2026-05-18T12:28:06Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:YFX7OTN2EAPUQ3ZU35CLWNZ42N","target":"record","payload":{"canonical_record":{"source":{"id":"1305.7478","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2013-05-31T16:26:14Z","cross_cats_sorted":["q-bio.PE"],"title_canon_sha256":"ab737d8cdd83b64cdc184860470e24c9b6fef708e857837ce94369182f1c94f6","abstract_canon_sha256":"91e2d88f9bfb9ad8f7039d7dcff513994101ce96023357dcd73cee052c56aefc"},"schema_version":"1.0"},"canonical_sha256":"c16ff74dba201f486f34df44bb373cd35d3a3873df8dd5a0c1fbaabc57b256a5","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:20:08.883054Z","signature_b64":"JK8eMyJM4Y2RoYDjBf5zbQpizkyHGjsKiRGvwkqgMhOadkZSep4qI4J9PrCc80ndn7hnqzgv5SEAhFiigdCACQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"c16ff74dba201f486f34df44bb373cd35d3a3873df8dd5a0c1fbaabc57b256a5","last_reissued_at":"2026-05-18T03:20:08.882310Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:20:08.882310Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1305.7478","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:20:08Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"MPwuQUj9/sfpNTDr7+a0ZofDEsM7/BaQnAGTClv87ZNQnov+sPdP07XdzYHBtkp/SVI1XmeOIUijEZBz2v+XDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T13:57:40.116539Z"},"content_sha256":"6a56a307fa373a2ff67b79e4ecde606d2e1c1c5f083789d48c8af69dbc3ea5b4","schema_version":"1.0","event_id":"sha256:6a56a307fa373a2ff67b79e4ecde606d2e1c1c5f083789d48c8af69dbc3ea5b4"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:YFX7OTN2EAPUQ3ZU35CLWNZ42N","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Cooperation and competition in the dynamics of tissue architecture during homeostasis and tumorigenesis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.PE"],"primary_cat":"q-bio.TO","authors_text":"Attila Csik\\'asz-Nagy, Buzz Baum, Luis M. Escudero, Martial Guillaud, Matteo Cavaliere, Sean Sedwards","submitted_at":"2013-05-31T16:26:14Z","abstract_excerpt":"The construction of a network of cell-to-cell contacts makes it possible to characterize the patterns and spatial organisation of tissues. Such networks are highly dynamic, depending on the changes of the tissue architecture caused by cell division, death and migration. Local competitive and cooperative cell-to-cell interactions influence the choices cells make. We review the literature on quantitative data of epithelial tissue topology and present a dynamical network model that can be used to explore the evolutionary dynamics of a two dimensional tissue architecture with arbitrary cell-to-cel"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1305.7478","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:20:08Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"dynCBdvwt9UjurI7wG3TdBhrBa6R2D1ouqxWj3lyaMWCooViixCchGZxHOeNfqeEFiXTnGh1e4cGSB0+EZoXAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T13:57:40.116896Z"},"content_sha256":"e2da5aaeb3485fe153807cf3460728928b1cec714d0b199a1246c423800f335d","schema_version":"1.0","event_id":"sha256:e2da5aaeb3485fe153807cf3460728928b1cec714d0b199a1246c423800f335d"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/YFX7OTN2EAPUQ3ZU35CLWNZ42N/bundle.json","state_url":"https://pith.science/pith/YFX7OTN2EAPUQ3ZU35CLWNZ42N/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/YFX7OTN2EAPUQ3ZU35CLWNZ42N/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-03T13:57:40Z","links":{"resolver":"https://pith.science/pith/YFX7OTN2EAPUQ3ZU35CLWNZ42N","bundle":"https://pith.science/pith/YFX7OTN2EAPUQ3ZU35CLWNZ42N/bundle.json","state":"https://pith.science/pith/YFX7OTN2EAPUQ3ZU35CLWNZ42N/state.json","well_known_bundle":"https://pith.science/.well-known/pith/YFX7OTN2EAPUQ3ZU35CLWNZ42N/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:YFX7OTN2EAPUQ3ZU35CLWNZ42N","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"91e2d88f9bfb9ad8f7039d7dcff513994101ce96023357dcd73cee052c56aefc","cross_cats_sorted":["q-bio.PE"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2013-05-31T16:26:14Z","title_canon_sha256":"ab737d8cdd83b64cdc184860470e24c9b6fef708e857837ce94369182f1c94f6"},"schema_version":"1.0","source":{"id":"1305.7478","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1305.7478","created_at":"2026-05-18T03:20:08Z"},{"alias_kind":"arxiv_version","alias_value":"1305.7478v2","created_at":"2026-05-18T03:20:08Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1305.7478","created_at":"2026-05-18T03:20:08Z"},{"alias_kind":"pith_short_12","alias_value":"YFX7OTN2EAPU","created_at":"2026-05-18T12:28:06Z"},{"alias_kind":"pith_short_16","alias_value":"YFX7OTN2EAPUQ3ZU","created_at":"2026-05-18T12:28:06Z"},{"alias_kind":"pith_short_8","alias_value":"YFX7OTN2","created_at":"2026-05-18T12:28:06Z"}],"graph_snapshots":[{"event_id":"sha256:e2da5aaeb3485fe153807cf3460728928b1cec714d0b199a1246c423800f335d","target":"graph","created_at":"2026-05-18T03:20:08Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The construction of a network of cell-to-cell contacts makes it possible to characterize the patterns and spatial organisation of tissues. Such networks are highly dynamic, depending on the changes of the tissue architecture caused by cell division, death and migration. Local competitive and cooperative cell-to-cell interactions influence the choices cells make. We review the literature on quantitative data of epithelial tissue topology and present a dynamical network model that can be used to explore the evolutionary dynamics of a two dimensional tissue architecture with arbitrary cell-to-cel","authors_text":"Attila Csik\\'asz-Nagy, Buzz Baum, Luis M. Escudero, Martial Guillaud, Matteo Cavaliere, Sean Sedwards","cross_cats":["q-bio.PE"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2013-05-31T16:26:14Z","title":"Cooperation and competition in the dynamics of tissue architecture during homeostasis and tumorigenesis"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1305.7478","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6a56a307fa373a2ff67b79e4ecde606d2e1c1c5f083789d48c8af69dbc3ea5b4","target":"record","created_at":"2026-05-18T03:20:08Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"91e2d88f9bfb9ad8f7039d7dcff513994101ce96023357dcd73cee052c56aefc","cross_cats_sorted":["q-bio.PE"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2013-05-31T16:26:14Z","title_canon_sha256":"ab737d8cdd83b64cdc184860470e24c9b6fef708e857837ce94369182f1c94f6"},"schema_version":"1.0","source":{"id":"1305.7478","kind":"arxiv","version":2}},"canonical_sha256":"c16ff74dba201f486f34df44bb373cd35d3a3873df8dd5a0c1fbaabc57b256a5","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"c16ff74dba201f486f34df44bb373cd35d3a3873df8dd5a0c1fbaabc57b256a5","first_computed_at":"2026-05-18T03:20:08.882310Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:20:08.882310Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"JK8eMyJM4Y2RoYDjBf5zbQpizkyHGjsKiRGvwkqgMhOadkZSep4qI4J9PrCc80ndn7hnqzgv5SEAhFiigdCACQ==","signature_status":"signed_v1","signed_at":"2026-05-18T03:20:08.883054Z","signed_message":"canonical_sha256_bytes"},"source_id":"1305.7478","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6a56a307fa373a2ff67b79e4ecde606d2e1c1c5f083789d48c8af69dbc3ea5b4","sha256:e2da5aaeb3485fe153807cf3460728928b1cec714d0b199a1246c423800f335d"],"state_sha256":"74b0dbc5d36851f37ee345af039040daa46e3f7df42b43a9b1cfe48259260aa8"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"WiaxAzZA2NRtfNBeD91CZv8I79+QIOtgiqB+m6vz5VoJ4BTSg2I6SpUpqgTflcD1YQlzLMwOg0Efxz7M2N9cCw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-03T13:57:40.118938Z","bundle_sha256":"34695e07eaaf00f5fa8f1020018926049f4cc8bde893af9ad7eb5ff3de6c931d"}}