{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:YJBIEXSDKWQGNK6NUA4U3RG5R4","short_pith_number":"pith:YJBIEXSD","canonical_record":{"source":{"id":"1805.06851","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2018-05-02T19:59:07Z","cross_cats_sorted":[],"title_canon_sha256":"c793a3e616a52a6e65f072a3d8aab2d0225b8c9119eefef3f4a75e59e6b70375","abstract_canon_sha256":"7e436a7bb612ba4a26091d47b573c068995c32aad4cd7e44b31775617c846b61"},"schema_version":"1.0"},"canonical_sha256":"c242825e4355a066abcda0394dc4dd8f183ff3e4c818e25d584619f16b5d9487","source":{"kind":"arxiv","id":"1805.06851","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1805.06851","created_at":"2026-05-18T00:15:43Z"},{"alias_kind":"arxiv_version","alias_value":"1805.06851v1","created_at":"2026-05-18T00:15:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1805.06851","created_at":"2026-05-18T00:15:43Z"},{"alias_kind":"pith_short_12","alias_value":"YJBIEXSDKWQG","created_at":"2026-05-18T12:33:04Z"},{"alias_kind":"pith_short_16","alias_value":"YJBIEXSDKWQGNK6N","created_at":"2026-05-18T12:33:04Z"},{"alias_kind":"pith_short_8","alias_value":"YJBIEXSD","created_at":"2026-05-18T12:33:04Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:YJBIEXSDKWQGNK6NUA4U3RG5R4","target":"record","payload":{"canonical_record":{"source":{"id":"1805.06851","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2018-05-02T19:59:07Z","cross_cats_sorted":[],"title_canon_sha256":"c793a3e616a52a6e65f072a3d8aab2d0225b8c9119eefef3f4a75e59e6b70375","abstract_canon_sha256":"7e436a7bb612ba4a26091d47b573c068995c32aad4cd7e44b31775617c846b61"},"schema_version":"1.0"},"canonical_sha256":"c242825e4355a066abcda0394dc4dd8f183ff3e4c818e25d584619f16b5d9487","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:15:43.129577Z","signature_b64":"kaDnAx8I8ocfzj+Y0el/+oMnrubjJs6HI9W/cSZvhYsrEinh7AyfI8C+UL+67acZAPRB2OzFVtjTauNCrIO/DQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"c242825e4355a066abcda0394dc4dd8f183ff3e4c818e25d584619f16b5d9487","last_reissued_at":"2026-05-18T00:15:43.128777Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:15:43.128777Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1805.06851","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:15:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"XG0k8SoHVuRAmKAI+4EWiYc0mpwzshCzPepoOwrbPgURAv9HxMcq96MxLqtuKR5DJDTrpzUt9tRZp5vFvAU+Bg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T03:34:21.469495Z"},"content_sha256":"f10caaf246efd505a862bbdf703a352e5b03783b667f6fb2bf20bb6c7781b2d3","schema_version":"1.0","event_id":"sha256:f10caaf246efd505a862bbdf703a352e5b03783b667f6fb2bf20bb6c7781b2d3"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:YJBIEXSDKWQGNK6NUA4U3RG5R4","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Do Bi-Stable Poisson-Nernst-Planck Models Describe Single Channel Gating?","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Bob Eisenberg, Chun Liu, Nir Gavish","submitted_at":"2018-05-02T19:59:07Z","abstract_excerpt":"Experiments measuring currents through single protein channels show unstable currents, a phenomena called the gating of a single channel. Channels switch between an 'open' state with a well defined single amplitude of current and 'closed' states with nearly zero current. The existing mean-field theory of ion channels focuses almost solely on the open state. The physical modeling of the dynamical features of ion channels is still in its infancy, and does not describe the transitions between open and closed states, nor the distribution of the duration times of open states. One hypothesis is that"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1805.06851","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:15:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"xsg59qeSjK2COOO4s5No0vqm7xX9aYw/MyuZB8u+kgAjEgghO2XzVEeVEEOYFjIRxXdAPxenFw367mqvQsR3Dg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T03:34:21.469849Z"},"content_sha256":"a66bccf63c8170e40c2330c999f97ee3fc660b3fc6aa3f3c652fa1e8189d51da","schema_version":"1.0","event_id":"sha256:a66bccf63c8170e40c2330c999f97ee3fc660b3fc6aa3f3c652fa1e8189d51da"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/YJBIEXSDKWQGNK6NUA4U3RG5R4/bundle.json","state_url":"https://pith.science/pith/YJBIEXSDKWQGNK6NUA4U3RG5R4/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/YJBIEXSDKWQGNK6NUA4U3RG5R4/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-01T03:34:21Z","links":{"resolver":"https://pith.science/pith/YJBIEXSDKWQGNK6NUA4U3RG5R4","bundle":"https://pith.science/pith/YJBIEXSDKWQGNK6NUA4U3RG5R4/bundle.json","state":"https://pith.science/pith/YJBIEXSDKWQGNK6NUA4U3RG5R4/state.json","well_known_bundle":"https://pith.science/.well-known/pith/YJBIEXSDKWQGNK6NUA4U3RG5R4/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:YJBIEXSDKWQGNK6NUA4U3RG5R4","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"7e436a7bb612ba4a26091d47b573c068995c32aad4cd7e44b31775617c846b61","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2018-05-02T19:59:07Z","title_canon_sha256":"c793a3e616a52a6e65f072a3d8aab2d0225b8c9119eefef3f4a75e59e6b70375"},"schema_version":"1.0","source":{"id":"1805.06851","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1805.06851","created_at":"2026-05-18T00:15:43Z"},{"alias_kind":"arxiv_version","alias_value":"1805.06851v1","created_at":"2026-05-18T00:15:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1805.06851","created_at":"2026-05-18T00:15:43Z"},{"alias_kind":"pith_short_12","alias_value":"YJBIEXSDKWQG","created_at":"2026-05-18T12:33:04Z"},{"alias_kind":"pith_short_16","alias_value":"YJBIEXSDKWQGNK6N","created_at":"2026-05-18T12:33:04Z"},{"alias_kind":"pith_short_8","alias_value":"YJBIEXSD","created_at":"2026-05-18T12:33:04Z"}],"graph_snapshots":[{"event_id":"sha256:a66bccf63c8170e40c2330c999f97ee3fc660b3fc6aa3f3c652fa1e8189d51da","target":"graph","created_at":"2026-05-18T00:15:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Experiments measuring currents through single protein channels show unstable currents, a phenomena called the gating of a single channel. Channels switch between an 'open' state with a well defined single amplitude of current and 'closed' states with nearly zero current. The existing mean-field theory of ion channels focuses almost solely on the open state. The physical modeling of the dynamical features of ion channels is still in its infancy, and does not describe the transitions between open and closed states, nor the distribution of the duration times of open states. One hypothesis is that","authors_text":"Bob Eisenberg, Chun Liu, Nir Gavish","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2018-05-02T19:59:07Z","title":"Do Bi-Stable Poisson-Nernst-Planck Models Describe Single Channel Gating?"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1805.06851","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f10caaf246efd505a862bbdf703a352e5b03783b667f6fb2bf20bb6c7781b2d3","target":"record","created_at":"2026-05-18T00:15:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"7e436a7bb612ba4a26091d47b573c068995c32aad4cd7e44b31775617c846b61","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2018-05-02T19:59:07Z","title_canon_sha256":"c793a3e616a52a6e65f072a3d8aab2d0225b8c9119eefef3f4a75e59e6b70375"},"schema_version":"1.0","source":{"id":"1805.06851","kind":"arxiv","version":1}},"canonical_sha256":"c242825e4355a066abcda0394dc4dd8f183ff3e4c818e25d584619f16b5d9487","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"c242825e4355a066abcda0394dc4dd8f183ff3e4c818e25d584619f16b5d9487","first_computed_at":"2026-05-18T00:15:43.128777Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:15:43.128777Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"kaDnAx8I8ocfzj+Y0el/+oMnrubjJs6HI9W/cSZvhYsrEinh7AyfI8C+UL+67acZAPRB2OzFVtjTauNCrIO/DQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:15:43.129577Z","signed_message":"canonical_sha256_bytes"},"source_id":"1805.06851","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f10caaf246efd505a862bbdf703a352e5b03783b667f6fb2bf20bb6c7781b2d3","sha256:a66bccf63c8170e40c2330c999f97ee3fc660b3fc6aa3f3c652fa1e8189d51da"],"state_sha256":"3b96691e898ac7f3bfa12a8f910cbc7e97b7b8f87fd636c5a2e4133a9295e1a8"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"1ixkibQhWDdMY26D8VV9ORbF9WXVAlEQDZCe2LLPyzwpKao0gG1mCeH0gZE3I0wMnCEOTFcLw8OmWipHpmyACg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-01T03:34:21.472104Z","bundle_sha256":"10521bd799f0642e1ffd4e3d78c68ba5bbfc752a869652249d1b0f2de5a5c418"}}