{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:YQLKITREQ7ZDXQKSQDHKRNHAWZ","short_pith_number":"pith:YQLKITRE","canonical_record":{"source":{"id":"1701.05078","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-01-18T14:36:14Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"50e32f2bb2b79a8122a2bcd285e2ad620e85977c97845b11fe2fb695c0a3d73e","abstract_canon_sha256":"933ccbf3a0cd7e0449b43b5578e4b804a2acc359f572d7772f2a90072fc7d4bc"},"schema_version":"1.0"},"canonical_sha256":"c416a44e2487f23bc15280cea8b4e0b67410447dd390f4647fe41b0d0b525bed","source":{"kind":"arxiv","id":"1701.05078","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1701.05078","created_at":"2026-05-18T00:30:05Z"},{"alias_kind":"arxiv_version","alias_value":"1701.05078v1","created_at":"2026-05-18T00:30:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1701.05078","created_at":"2026-05-18T00:30:05Z"},{"alias_kind":"pith_short_12","alias_value":"YQLKITREQ7ZD","created_at":"2026-05-18T12:31:56Z"},{"alias_kind":"pith_short_16","alias_value":"YQLKITREQ7ZDXQKS","created_at":"2026-05-18T12:31:56Z"},{"alias_kind":"pith_short_8","alias_value":"YQLKITRE","created_at":"2026-05-18T12:31:56Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:YQLKITREQ7ZDXQKSQDHKRNHAWZ","target":"record","payload":{"canonical_record":{"source":{"id":"1701.05078","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-01-18T14:36:14Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"50e32f2bb2b79a8122a2bcd285e2ad620e85977c97845b11fe2fb695c0a3d73e","abstract_canon_sha256":"933ccbf3a0cd7e0449b43b5578e4b804a2acc359f572d7772f2a90072fc7d4bc"},"schema_version":"1.0"},"canonical_sha256":"c416a44e2487f23bc15280cea8b4e0b67410447dd390f4647fe41b0d0b525bed","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:30:05.873084Z","signature_b64":"7QWZv7h4Ml07hCl1190xzP3ABGfn1wjZxrx7ztBfA39I/4UW9XGw/CWAN94Kml9QQGgzxNdXWBgPcuCf0r9ICA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"c416a44e2487f23bc15280cea8b4e0b67410447dd390f4647fe41b0d0b525bed","last_reissued_at":"2026-05-18T00:30:05.872640Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:30:05.872640Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1701.05078","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:30:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"OpTO4DXXGdYROvUr1hJZjk0ycSKUxFtUiNMSWuav+bMyfkfJlrZpU/PuieWTUo/ue3uapwDaCmnpIWdLjbiXAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-28T14:15:57.060951Z"},"content_sha256":"b65163b6cd745e8fb708cc7e708a0d52de06faa8d8b85b0153d7e109961a0fc4","schema_version":"1.0","event_id":"sha256:b65163b6cd745e8fb708cc7e708a0d52de06faa8d8b85b0153d7e109961a0fc4"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:YQLKITREQ7ZDXQKSQDHKRNHAWZ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Deciphering intrinsic inter-subunit couplings that lead to sequential hydrolysis of F1-ATPase ring","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"physics.bio-ph","authors_text":"Holger Flechsig, Jin Yu, Liqiang Dai","submitted_at":"2017-01-18T14:36:14Z","abstract_excerpt":"The rotary sequential hydrolysis of metabolic machine F1-ATPase is a prominent feature to reveal high coordination among multiple chemical sites on the stator F1 ring, which also contributes to tight coupling between the chemical reaction and central {\\gamma}-shaft rotation. High-speed AFM experiments discovered that the sequential hydrolysis was maintained on the F1 ring even in the absence of the {\\gamma} rotor. To explore how the intrinsic sequential performance arises, we computationally investigated essential inter-subunit couplings on the hexameric ring of mitochondrial and bacterial F1."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1701.05078","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:30:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"LF6iZrbpRydjewjqWQMqMiCaqRe6clxHlbQ7Bg5rRv+ZIi9d5P5rg9BUZhFfz7B1l+rin4qhRNJe/ew5KhzwBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-28T14:15:57.061296Z"},"content_sha256":"a1835dad99f81d5597be53262a3ac549120d05d51734fcc8992a6fd532a047cd","schema_version":"1.0","event_id":"sha256:a1835dad99f81d5597be53262a3ac549120d05d51734fcc8992a6fd532a047cd"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/YQLKITREQ7ZDXQKSQDHKRNHAWZ/bundle.json","state_url":"https://pith.science/pith/YQLKITREQ7ZDXQKSQDHKRNHAWZ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/YQLKITREQ7ZDXQKSQDHKRNHAWZ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-28T14:15:57Z","links":{"resolver":"https://pith.science/pith/YQLKITREQ7ZDXQKSQDHKRNHAWZ","bundle":"https://pith.science/pith/YQLKITREQ7ZDXQKSQDHKRNHAWZ/bundle.json","state":"https://pith.science/pith/YQLKITREQ7ZDXQKSQDHKRNHAWZ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/YQLKITREQ7ZDXQKSQDHKRNHAWZ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:YQLKITREQ7ZDXQKSQDHKRNHAWZ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"933ccbf3a0cd7e0449b43b5578e4b804a2acc359f572d7772f2a90072fc7d4bc","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-01-18T14:36:14Z","title_canon_sha256":"50e32f2bb2b79a8122a2bcd285e2ad620e85977c97845b11fe2fb695c0a3d73e"},"schema_version":"1.0","source":{"id":"1701.05078","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1701.05078","created_at":"2026-05-18T00:30:05Z"},{"alias_kind":"arxiv_version","alias_value":"1701.05078v1","created_at":"2026-05-18T00:30:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1701.05078","created_at":"2026-05-18T00:30:05Z"},{"alias_kind":"pith_short_12","alias_value":"YQLKITREQ7ZD","created_at":"2026-05-18T12:31:56Z"},{"alias_kind":"pith_short_16","alias_value":"YQLKITREQ7ZDXQKS","created_at":"2026-05-18T12:31:56Z"},{"alias_kind":"pith_short_8","alias_value":"YQLKITRE","created_at":"2026-05-18T12:31:56Z"}],"graph_snapshots":[{"event_id":"sha256:a1835dad99f81d5597be53262a3ac549120d05d51734fcc8992a6fd532a047cd","target":"graph","created_at":"2026-05-18T00:30:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The rotary sequential hydrolysis of metabolic machine F1-ATPase is a prominent feature to reveal high coordination among multiple chemical sites on the stator F1 ring, which also contributes to tight coupling between the chemical reaction and central {\\gamma}-shaft rotation. High-speed AFM experiments discovered that the sequential hydrolysis was maintained on the F1 ring even in the absence of the {\\gamma} rotor. To explore how the intrinsic sequential performance arises, we computationally investigated essential inter-subunit couplings on the hexameric ring of mitochondrial and bacterial F1.","authors_text":"Holger Flechsig, Jin Yu, Liqiang Dai","cross_cats":["q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-01-18T14:36:14Z","title":"Deciphering intrinsic inter-subunit couplings that lead to sequential hydrolysis of F1-ATPase ring"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1701.05078","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b65163b6cd745e8fb708cc7e708a0d52de06faa8d8b85b0153d7e109961a0fc4","target":"record","created_at":"2026-05-18T00:30:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"933ccbf3a0cd7e0449b43b5578e4b804a2acc359f572d7772f2a90072fc7d4bc","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-01-18T14:36:14Z","title_canon_sha256":"50e32f2bb2b79a8122a2bcd285e2ad620e85977c97845b11fe2fb695c0a3d73e"},"schema_version":"1.0","source":{"id":"1701.05078","kind":"arxiv","version":1}},"canonical_sha256":"c416a44e2487f23bc15280cea8b4e0b67410447dd390f4647fe41b0d0b525bed","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"c416a44e2487f23bc15280cea8b4e0b67410447dd390f4647fe41b0d0b525bed","first_computed_at":"2026-05-18T00:30:05.872640Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:30:05.872640Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"7QWZv7h4Ml07hCl1190xzP3ABGfn1wjZxrx7ztBfA39I/4UW9XGw/CWAN94Kml9QQGgzxNdXWBgPcuCf0r9ICA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:30:05.873084Z","signed_message":"canonical_sha256_bytes"},"source_id":"1701.05078","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b65163b6cd745e8fb708cc7e708a0d52de06faa8d8b85b0153d7e109961a0fc4","sha256:a1835dad99f81d5597be53262a3ac549120d05d51734fcc8992a6fd532a047cd"],"state_sha256":"ae281b3670d217d8f8c52055d24da0b875f453c7b571c00c691d7767875161b4"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"nySxzYmTRbNbrd6T04jXSC/oApZCmrz6wX4aqfKSbYIw28ttu6a74ZN7gXN0cVAflxMzCoMMRuMHOKWye0dDDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-28T14:15:57.063199Z","bundle_sha256":"d8da5e69420d82f13bfdcf82e57c673e4bf0fbfcbc151f6fefbd693294d0e9a1"}}