{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2012:YRTWYLRZXMEZBMA6N4DJLM7VKW","short_pith_number":"pith:YRTWYLRZ","schema_version":"1.0","canonical_sha256":"c4676c2e39bb0990b01e6f0695b3f5558ca4152ec60245f324352ea8f67e6618","source":{"kind":"arxiv","id":"1202.2495","version":2},"attestation_state":"computed","paper":{"title":"Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells","license":"http://creativecommons.org/licenses/by/3.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"q-bio.MN","authors_text":"Jianhua Xing, John J Tyson, Liwu Li, Meng Zhu, Ping Wang, Trevor Glaros, Yan Fu, Zhanghan Wu","submitted_at":"2012-02-12T07:39:36Z","abstract_excerpt":"The innate immune system, acting as the first line of host defense, senses and adapts to foreign challenges through complex intracellular and intercellular signaling networks. Endotoxin tolerance and priming elicited by macrophages are classic examples of the complex adaptation of innate immune cells. Upon repetitive exposures to different doses of bacterial endotoxin (lipopolysaccharide) or other stimulants, macrophages show either suppressed or augmented inflammatory responses compared to a single exposure to the stimulant. Endotoxin tolerance and priming are critically involved in both immu"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1202.2495","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/3.0/","primary_cat":"q-bio.MN","submitted_at":"2012-02-12T07:39:36Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"8e616fc336a89a5deee9527ef819ff5adba79d3f98cb287be4e501ef22ab2f6b","abstract_canon_sha256":"540fd8254cd46761347e7fad4d760e92726b02a3f37fb6f50d37e56cd4675492"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:37:37.831916Z","signature_b64":"Z0X8qrytTwXi/CCBdbV+uSX46fwM6XISIUDR+VVULiI0Od//nLFMAUIUXLtWc270e2oQbrxWXqlTA2bbfrzuAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"c4676c2e39bb0990b01e6f0695b3f5558ca4152ec60245f324352ea8f67e6618","last_reissued_at":"2026-05-18T00:37:37.831248Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:37:37.831248Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells","license":"http://creativecommons.org/licenses/by/3.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"q-bio.MN","authors_text":"Jianhua Xing, John J Tyson, Liwu Li, Meng Zhu, Ping Wang, Trevor Glaros, Yan Fu, Zhanghan Wu","submitted_at":"2012-02-12T07:39:36Z","abstract_excerpt":"The innate immune system, acting as the first line of host defense, senses and adapts to foreign challenges through complex intracellular and intercellular signaling networks. Endotoxin tolerance and priming elicited by macrophages are classic examples of the complex adaptation of innate immune cells. Upon repetitive exposures to different doses of bacterial endotoxin (lipopolysaccharide) or other stimulants, macrophages show either suppressed or augmented inflammatory responses compared to a single exposure to the stimulant. Endotoxin tolerance and priming are critically involved in both immu"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1202.2495","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1202.2495","created_at":"2026-05-18T00:37:37.831371+00:00"},{"alias_kind":"arxiv_version","alias_value":"1202.2495v2","created_at":"2026-05-18T00:37:37.831371+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1202.2495","created_at":"2026-05-18T00:37:37.831371+00:00"},{"alias_kind":"pith_short_12","alias_value":"YRTWYLRZXMEZ","created_at":"2026-05-18T12:27:30.460161+00:00"},{"alias_kind":"pith_short_16","alias_value":"YRTWYLRZXMEZBMA6","created_at":"2026-05-18T12:27:30.460161+00:00"},{"alias_kind":"pith_short_8","alias_value":"YRTWYLRZ","created_at":"2026-05-18T12:27:30.460161+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/YRTWYLRZXMEZBMA6N4DJLM7VKW","json":"https://pith.science/pith/YRTWYLRZXMEZBMA6N4DJLM7VKW.json","graph_json":"https://pith.science/api/pith-number/YRTWYLRZXMEZBMA6N4DJLM7VKW/graph.json","events_json":"https://pith.science/api/pith-number/YRTWYLRZXMEZBMA6N4DJLM7VKW/events.json","paper":"https://pith.science/paper/YRTWYLRZ"},"agent_actions":{"view_html":"https://pith.science/pith/YRTWYLRZXMEZBMA6N4DJLM7VKW","download_json":"https://pith.science/pith/YRTWYLRZXMEZBMA6N4DJLM7VKW.json","view_paper":"https://pith.science/paper/YRTWYLRZ","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1202.2495&json=true","fetch_graph":"https://pith.science/api/pith-number/YRTWYLRZXMEZBMA6N4DJLM7VKW/graph.json","fetch_events":"https://pith.science/api/pith-number/YRTWYLRZXMEZBMA6N4DJLM7VKW/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/YRTWYLRZXMEZBMA6N4DJLM7VKW/action/timestamp_anchor","attest_storage":"https://pith.science/pith/YRTWYLRZXMEZBMA6N4DJLM7VKW/action/storage_attestation","attest_author":"https://pith.science/pith/YRTWYLRZXMEZBMA6N4DJLM7VKW/action/author_attestation","sign_citation":"https://pith.science/pith/YRTWYLRZXMEZBMA6N4DJLM7VKW/action/citation_signature","submit_replication":"https://pith.science/pith/YRTWYLRZXMEZBMA6N4DJLM7VKW/action/replication_record"}},"created_at":"2026-05-18T00:37:37.831371+00:00","updated_at":"2026-05-18T00:37:37.831371+00:00"}