{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:YXCZQPZ52EMMSUN3GJQDG3TSW7","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"072793ae717f9053634edc9a33fbba8d32644e3ffe03d8361a57d97240910ab1","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2026-07-05T09:53:35Z","title_canon_sha256":"b0a8a6ef651651c739c7b32ab8bc7fd9b015455dac82ac32e84a6374b0503e0f"},"schema_version":"1.0","source":{"id":"2607.04205","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2607.04205","created_at":"2026-07-07T02:19:02Z"},{"alias_kind":"arxiv_version","alias_value":"2607.04205v1","created_at":"2026-07-07T02:19:02Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2607.04205","created_at":"2026-07-07T02:19:02Z"},{"alias_kind":"pith_short_12","alias_value":"YXCZQPZ52EMM","created_at":"2026-07-07T02:19:02Z"},{"alias_kind":"pith_short_16","alias_value":"YXCZQPZ52EMMSUN3","created_at":"2026-07-07T02:19:02Z"},{"alias_kind":"pith_short_8","alias_value":"YXCZQPZ5","created_at":"2026-07-07T02:19:02Z"}],"graph_snapshots":[{"event_id":"sha256:a59527f061e959ac841ddd51b241ddd46c1b13ffc0d9796d5fa5f2ed9359a3c7","target":"graph","created_at":"2026-07-07T02:19:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2607.04205/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Confirmatory phase III trials require rigorous evidence, yet for first-in-class (FIC) therapies they must often be designed when same-mechanism evidence is scarce. This uncertainty motivates planned interim analyses and makes phase II data from the same therapy a relevant source of prior evidence. However, both borrowing and repeated interim analyses must be calibrated to control the overall type I error rate. Because borrowing changes the evidence available at interim analyses relative to a non-borrowing group sequential design (GSD), it also raises the question of whether interim analysis ti","authors_text":"Cong Zhang, Jiali Song, Leen Huang, Meihua Long, Qimeng Che, Tianyu Zheng, Yan Hou","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2026-07-05T09:53:35Z","title":"A Bayesian predictive framework for adaptive interim-analysis timing with robust borrowing in confirmatory trials"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.04205","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:20d4949aa867b21ef6d026f1cb77f0651d4f1f1daae4ab93979b6031c93d2140","target":"record","created_at":"2026-07-07T02:19:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"072793ae717f9053634edc9a33fbba8d32644e3ffe03d8361a57d97240910ab1","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2026-07-05T09:53:35Z","title_canon_sha256":"b0a8a6ef651651c739c7b32ab8bc7fd9b015455dac82ac32e84a6374b0503e0f"},"schema_version":"1.0","source":{"id":"2607.04205","kind":"arxiv","version":1}},"canonical_sha256":"c5c5983f3dd118c951bb3260336e72b7e36265abc6d81a10e9cd99a2a4ae8d49","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"c5c5983f3dd118c951bb3260336e72b7e36265abc6d81a10e9cd99a2a4ae8d49","first_computed_at":"2026-07-07T02:19:02.969300Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-07T02:19:02.969300Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"qoUyvKR1XnPFQdSnJkNsvo1KXcn8VIJYzZN/VAiNLbm6Au3hjqpmzwMnS1kEV6McbrJxBMhg9DVHCuRJTTYIAQ==","signature_status":"signed_v1","signed_at":"2026-07-07T02:19:02.970210Z","signed_message":"canonical_sha256_bytes"},"source_id":"2607.04205","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:20d4949aa867b21ef6d026f1cb77f0651d4f1f1daae4ab93979b6031c93d2140","sha256:a59527f061e959ac841ddd51b241ddd46c1b13ffc0d9796d5fa5f2ed9359a3c7"],"state_sha256":"9e4feaca1c1541c2eaf2068b7f8adc6bcfafda8dba26260b3c8f946e2b2b9676"}