{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:Z572OEMDW7JWCCGNLJFI725CAC","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"5ce948667ae09b962d564ae72f8d9231db0631777697b514f85bde3430d3d77f","cross_cats_sorted":["physics.chem-ph","q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-03-20T16:58:14Z","title_canon_sha256":"ac365b08aa9b7a929999d4d5d36b1c5524bb43914a3b8ea77b5b66c60059030d"},"schema_version":"1.0","source":{"id":"1903.08615","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1903.08615","created_at":"2026-05-17T23:39:44Z"},{"alias_kind":"arxiv_version","alias_value":"1903.08615v2","created_at":"2026-05-17T23:39:44Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1903.08615","created_at":"2026-05-17T23:39:44Z"},{"alias_kind":"pith_short_12","alias_value":"Z572OEMDW7JW","created_at":"2026-05-18T12:33:33Z"},{"alias_kind":"pith_short_16","alias_value":"Z572OEMDW7JWCCGN","created_at":"2026-05-18T12:33:33Z"},{"alias_kind":"pith_short_8","alias_value":"Z572OEMD","created_at":"2026-05-18T12:33:33Z"}],"graph_snapshots":[{"event_id":"sha256:779875a0762f5f6309c542bff2d31ad0fc48fbb78d9c366ec5c1dbfad64fc680","target":"graph","created_at":"2026-05-17T23:39:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Various kinetic Monte Carlo algorithms become inefficient when some of the population sizes in a system are large, which gives rise to a large number of reaction events per unit time. Here, we present a new acceleration algorithm based on adaptive and heterogeneous scaling of reaction rates and stoichiometric coefficients. The algorithm is conceptually related to the commonly used idea of accelerating a stochastic simulation by considering a sub-volume $\\lambda \\Omega$ ($0<\\lambda<1$) within a system of interest, which reduces the number of reaction events per unit time occurring in a simulati","authors_text":"Song Feng, William S. Hlavacek, Yen Ting Lin","cross_cats":["physics.chem-ph","q-bio.MN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-03-20T16:58:14Z","title":"Scaling methods for accelerating kinetic Monte Carlo simulations of chemical reaction networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1903.08615","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:5178900548579e0212e35734f52ac6e1c283bdbba2868bb033868d7b9783252a","target":"record","created_at":"2026-05-17T23:39:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"5ce948667ae09b962d564ae72f8d9231db0631777697b514f85bde3430d3d77f","cross_cats_sorted":["physics.chem-ph","q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-03-20T16:58:14Z","title_canon_sha256":"ac365b08aa9b7a929999d4d5d36b1c5524bb43914a3b8ea77b5b66c60059030d"},"schema_version":"1.0","source":{"id":"1903.08615","kind":"arxiv","version":2}},"canonical_sha256":"cf7fa71183b7d36108cd5a4a8feba200b354a5789ef75d4e112caf97aa0bca1a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"cf7fa71183b7d36108cd5a4a8feba200b354a5789ef75d4e112caf97aa0bca1a","first_computed_at":"2026-05-17T23:39:44.740605Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:39:44.740605Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"8tYQP8/LTuNcjkiK1PmWVrwtgYErmbSSZvUA9//3div9aYG62K976cE3y96O+AgZkfZMbtwHrtV8Yt67QC2PAA==","signature_status":"signed_v1","signed_at":"2026-05-17T23:39:44.741458Z","signed_message":"canonical_sha256_bytes"},"source_id":"1903.08615","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:5178900548579e0212e35734f52ac6e1c283bdbba2868bb033868d7b9783252a","sha256:779875a0762f5f6309c542bff2d31ad0fc48fbb78d9c366ec5c1dbfad64fc680"],"state_sha256":"0d8af09d3f0f41b1bfa1826393ceedf56a97cea91349e5db256d666ea70213dc"}