{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:Z6BYQOCR5BYQXTMATHDR57KYGL","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6f869f53040814e12f4202535784e70d169327f06d08fd9d82d62333939fd588","cross_cats_sorted":["cs.CE","q-bio.BM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2025-09-08T09:24:09Z","title_canon_sha256":"99e93baaf3e45f990e7be3ea9f9bb740e0de4a4d7713de3b3ae1c07d9d340b30"},"schema_version":"1.0","source":{"id":"2509.06465","kind":"arxiv","version":4}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2509.06465","created_at":"2026-07-05T12:09:24Z"},{"alias_kind":"arxiv_version","alias_value":"2509.06465v4","created_at":"2026-07-05T12:09:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2509.06465","created_at":"2026-07-05T12:09:24Z"},{"alias_kind":"pith_short_12","alias_value":"Z6BYQOCR5BYQ","created_at":"2026-07-05T12:09:24Z"},{"alias_kind":"pith_short_16","alias_value":"Z6BYQOCR5BYQXTMA","created_at":"2026-07-05T12:09:24Z"},{"alias_kind":"pith_short_8","alias_value":"Z6BYQOCR","created_at":"2026-07-05T12:09:24Z"}],"graph_snapshots":[{"event_id":"sha256:0e7f40f1e3c64b72b1426e4d60db362d23ea97a1a77147a6ea58fbed28ef915f","target":"graph","created_at":"2026-07-05T12:09:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2509.06465/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Antibody binding site prediction plays a pivotal role in computational immunology and therapeutic antibody design. Existing sequence or structure methods rely on single-view features and fail to identify antibody-specific binding sites on the antigens. In this paper, we propose \\textbf{CAME-AB}, a novel Cross-modality Attention framework with a Mixture-of-Experts (MoE) backbone for robust antibody binding site prediction. CAME-AB integrates five biologically grounded modalities, including raw amino acid encodings, BLOSUM substitution profiles, pretrained language model embeddings, structure-aw","authors_text":"Fanming Jin, Hangjun Che, Hongzong Li, Jiahao Ma, Jian-Dong Huang, Rui Xiao, Ye-Fan Hu, Zhanpeng Shi","cross_cats":["cs.CE","q-bio.BM"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2025-09-08T09:24:09Z","title":"CAME-AB: Cross-Modality Attention with Mixture-of-Experts for Antibody Binding Site Prediction"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2509.06465","kind":"arxiv","version":4},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:dbf08fb9ea6881e2b1d68f21110542723443de0e9c0deae82cb129f16ab15851","target":"record","created_at":"2026-07-05T12:09:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6f869f53040814e12f4202535784e70d169327f06d08fd9d82d62333939fd588","cross_cats_sorted":["cs.CE","q-bio.BM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2025-09-08T09:24:09Z","title_canon_sha256":"99e93baaf3e45f990e7be3ea9f9bb740e0de4a4d7713de3b3ae1c07d9d340b30"},"schema_version":"1.0","source":{"id":"2509.06465","kind":"arxiv","version":4}},"canonical_sha256":"cf83883851e8710bcd8099c71efd5832ee24f6701227098872464cc9283367c8","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"cf83883851e8710bcd8099c71efd5832ee24f6701227098872464cc9283367c8","first_computed_at":"2026-07-05T12:09:24.256573Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T12:09:24.256573Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Omzkb4FAC5zDuNuFIxUpge403vkj/g/7MG/iqnhiuZpErobVEXVOK9KhD2mjBa9ta1Oi4WIN94y8PmukB4diBw==","signature_status":"signed_v1","signed_at":"2026-07-05T12:09:24.257036Z","signed_message":"canonical_sha256_bytes"},"source_id":"2509.06465","source_kind":"arxiv","source_version":4}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:dbf08fb9ea6881e2b1d68f21110542723443de0e9c0deae82cb129f16ab15851","sha256:0e7f40f1e3c64b72b1426e4d60db362d23ea97a1a77147a6ea58fbed28ef915f"],"state_sha256":"2224d5e086d639f615b6af2f5f0ba55bbbbd4c030c17495a0f909541cbd7b139"}