{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:Z6GDTPRYDO2LU2YDFYACO4ECI5","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"399ca9ff42d179914eddda9c1b808c08d2ead453d2ec5391ef73f4ab411d35ae","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.NC","submitted_at":"2025-08-13T18:49:11Z","title_canon_sha256":"239bb050025df26b960323edcbffeb6c2b9a02175cf095e9878ca9d87b6f5a1a"},"schema_version":"1.0","source":{"id":"2508.10130","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2508.10130","created_at":"2026-07-05T11:53:32Z"},{"alias_kind":"arxiv_version","alias_value":"2508.10130v1","created_at":"2026-07-05T11:53:32Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2508.10130","created_at":"2026-07-05T11:53:32Z"},{"alias_kind":"pith_short_12","alias_value":"Z6GDTPRYDO2L","created_at":"2026-07-05T11:53:32Z"},{"alias_kind":"pith_short_16","alias_value":"Z6GDTPRYDO2LU2YD","created_at":"2026-07-05T11:53:32Z"},{"alias_kind":"pith_short_8","alias_value":"Z6GDTPRY","created_at":"2026-07-05T11:53:32Z"}],"graph_snapshots":[{"event_id":"sha256:d5a5f2119e8817ee2556f58faf74b64fa6ca6a2bbf0e7a8b33b9992cf55cbe2d","target":"graph","created_at":"2026-07-05T11:53:32Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2508.10130/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Background: Glial fibrillary acidic protein (GFAP) is a biomarker for intracerebral hemorrhage and traumatic brain injury, but its link to acute speech disruption is untested. Speech anomalies often emerge early after injury, enabling rapid triage.\n  Methods: We simulated a cohort of 200 virtual patients stratified by lesion location, onset time, and severity. GFAP kinetics followed published trajectories; speech anomalies were generated from lesion-specific neurophysiological mappings. Ensemble machine-learning models used GFAP, speech, and lesion features; robustness was tested under noise, ","authors_text":"Bin Hu, Shamaley Aravinthan","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.NC","submitted_at":"2025-08-13T18:49:11Z","title":"Linking GFAP Levels to Speech Anomalies in Acute Brain Injury: A Simulation Based Study"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.10130","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:05af782086e0c4a649df15bd9f2a98afb30cf48c0d851d12643c54c59206925e","target":"record","created_at":"2026-07-05T11:53:32Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"399ca9ff42d179914eddda9c1b808c08d2ead453d2ec5391ef73f4ab411d35ae","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.NC","submitted_at":"2025-08-13T18:49:11Z","title_canon_sha256":"239bb050025df26b960323edcbffeb6c2b9a02175cf095e9878ca9d87b6f5a1a"},"schema_version":"1.0","source":{"id":"2508.10130","kind":"arxiv","version":1}},"canonical_sha256":"cf8c39be381bb4ba6b032e002770824779a07ad44dadfa223100ee4ae526ba50","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"cf8c39be381bb4ba6b032e002770824779a07ad44dadfa223100ee4ae526ba50","first_computed_at":"2026-07-05T11:53:32.160230Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:53:32.160230Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"kwBtii4r5QSGzCu4HjOOB47p/OarM4m3x/o1SkYu3AgbfywYzlCYmjYdkFBOYkAk81xRaCkP87wWSXvA8FeDDg==","signature_status":"signed_v1","signed_at":"2026-07-05T11:53:32.160793Z","signed_message":"canonical_sha256_bytes"},"source_id":"2508.10130","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:05af782086e0c4a649df15bd9f2a98afb30cf48c0d851d12643c54c59206925e","sha256:d5a5f2119e8817ee2556f58faf74b64fa6ca6a2bbf0e7a8b33b9992cf55cbe2d"],"state_sha256":"a7923fa4bf093a0a9ac2c8ddcf6cc9ca052bdd1253653e8eea0976757ee59ad8"}