{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2012:Z7OL562IPBWJLFBJ5CSMI7HP2Q","short_pith_number":"pith:Z7OL562I","schema_version":"1.0","canonical_sha256":"cfdcbefb48786c959429e8a4c47cefd43a2044781b81983d74faa9ab52152bcc","source":{"kind":"arxiv","id":"1205.0381","version":3},"attestation_state":"computed","paper":{"title":"Origins of Binary Gene Expression in Post-transcriptional Regulation by MicroRNAs","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.MN"],"primary_cat":"q-bio.QM","authors_text":"Indrani Bose, Sayantari Ghosh","submitted_at":"2012-05-02T11:08:36Z","abstract_excerpt":"MicroRNA-mediated regulation of gene expression is characterised by some distinctive features that set it apart from unregulated and transcription factor-regulated gene expression. Recently, a mathematical model has been proposed to describe the dynamics of post-transcriptional regulation by microRNAs. The model explains the observations made in single cell experiments quite well. In this paper, we introduce some additional features into the model and consider two specific cases. In the first case, a non-cooperative positive feedback loop is included in the transcriptional regulation of the ta"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1205.0381","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2012-05-02T11:08:36Z","cross_cats_sorted":["q-bio.MN"],"title_canon_sha256":"1dfee78e1191cad4bd524fe8e0f53ca009e069c23044a97484068ed514f698ad","abstract_canon_sha256":"06bf11cc704dcbad0fe1e741668fad6d3c19ecd3ba2d820a21469d8d51b511bc"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:42:55.802732Z","signature_b64":"QaBTzlnCdWae/x/iFHn1o5B+g2MF2Bn2WQzO4nLp5JhGA99GuE/Raj9Pk3Jp5bkpB3Lm6QvO2p4dnTjd9TOxBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"cfdcbefb48786c959429e8a4c47cefd43a2044781b81983d74faa9ab52152bcc","last_reissued_at":"2026-05-18T03:42:55.802106Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:42:55.802106Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Origins of Binary Gene Expression in Post-transcriptional Regulation by MicroRNAs","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.MN"],"primary_cat":"q-bio.QM","authors_text":"Indrani Bose, Sayantari Ghosh","submitted_at":"2012-05-02T11:08:36Z","abstract_excerpt":"MicroRNA-mediated regulation of gene expression is characterised by some distinctive features that set it apart from unregulated and transcription factor-regulated gene expression. Recently, a mathematical model has been proposed to describe the dynamics of post-transcriptional regulation by microRNAs. The model explains the observations made in single cell experiments quite well. In this paper, we introduce some additional features into the model and consider two specific cases. In the first case, a non-cooperative positive feedback loop is included in the transcriptional regulation of the ta"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1205.0381","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1205.0381","created_at":"2026-05-18T03:42:55.802212+00:00"},{"alias_kind":"arxiv_version","alias_value":"1205.0381v3","created_at":"2026-05-18T03:42:55.802212+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1205.0381","created_at":"2026-05-18T03:42:55.802212+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/Z7OL562IPBWJLFBJ5CSMI7HP2Q","json":"https://pith.science/pith/Z7OL562IPBWJLFBJ5CSMI7HP2Q.json","graph_json":"https://pith.science/api/pith-number/Z7OL562IPBWJLFBJ5CSMI7HP2Q/graph.json","events_json":"https://pith.science/api/pith-number/Z7OL562IPBWJLFBJ5CSMI7HP2Q/events.json","paper":"https://pith.science/paper/Z7OL562I"},"agent_actions":{"view_html":"https://pith.science/pith/Z7OL562IPBWJLFBJ5CSMI7HP2Q","download_json":"https://pith.science/pith/Z7OL562IPBWJLFBJ5CSMI7HP2Q.json","view_paper":"https://pith.science/paper/Z7OL562I","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1205.0381&json=true","fetch_graph":"https://pith.science/api/pith-number/Z7OL562IPBWJLFBJ5CSMI7HP2Q/graph.json","fetch_events":"https://pith.science/api/pith-number/Z7OL562IPBWJLFBJ5CSMI7HP2Q/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/Z7OL562IPBWJLFBJ5CSMI7HP2Q/action/timestamp_anchor","attest_storage":"https://pith.science/pith/Z7OL562IPBWJLFBJ5CSMI7HP2Q/action/storage_attestation","attest_author":"https://pith.science/pith/Z7OL562IPBWJLFBJ5CSMI7HP2Q/action/author_attestation","sign_citation":"https://pith.science/pith/Z7OL562IPBWJLFBJ5CSMI7HP2Q/action/citation_signature","submit_replication":"https://pith.science/pith/Z7OL562IPBWJLFBJ5CSMI7HP2Q/action/replication_record"}},"created_at":"2026-05-18T03:42:55.802212+00:00","updated_at":"2026-05-18T03:42:55.802212+00:00"}