{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2012:Z7TG46V3SVMOKL5U2N5BNMAWY7","short_pith_number":"pith:Z7TG46V3","schema_version":"1.0","canonical_sha256":"cfe66e7abb9558e52fb4d37a16b016c7f57d402228d974f798c3a000d2e2bf8c","source":{"kind":"arxiv","id":"1209.4487","version":1},"attestation_state":"computed","paper":{"title":"The role of tunable activation thresholds in the dynamics of autoimmunity","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["nlin.CD","q-bio.QM"],"primary_cat":"q-bio.PE","authors_text":"K.B. Blyuss, L.B. Nicholson","submitted_at":"2012-09-20T10:19:38Z","abstract_excerpt":"It has been known for some time that human autoimmune diseases can be triggered by viral infections. Several possible mechanisms of interactions between a virus and immune system have been analysed, with a prevailing opinion being that the onset of autoimmunity can in many cases be attributed to \"molecular mimicry\", where linear peptide epitopes, processed from viral proteins, mimic normal host self proteins, thus leading to a cross-reaction of immune response against virus with host cells. In this paper we present a mathematical model for the dynamics of an immune response to a viral infectio"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1209.4487","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2012-09-20T10:19:38Z","cross_cats_sorted":["nlin.CD","q-bio.QM"],"title_canon_sha256":"b5375717a65f1f9bea66270c2413b248e421d536b6e56340a6fba8677fd80745","abstract_canon_sha256":"52a5f3d34a05f2eeede084c86f3d25aa92dbea7e369dc2533fb5b646d7037ac4"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:45:11.569865Z","signature_b64":"ph0YBTQXYB52kkU4zAr9H2WlshGGO/vTHXwXDlHL7KdeHRVtmt607xuMDHFW1patb1BquBjLfap4PvK1iTvcAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"cfe66e7abb9558e52fb4d37a16b016c7f57d402228d974f798c3a000d2e2bf8c","last_reissued_at":"2026-05-18T03:45:11.569093Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:45:11.569093Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"The role of tunable activation thresholds in the dynamics of autoimmunity","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["nlin.CD","q-bio.QM"],"primary_cat":"q-bio.PE","authors_text":"K.B. Blyuss, L.B. Nicholson","submitted_at":"2012-09-20T10:19:38Z","abstract_excerpt":"It has been known for some time that human autoimmune diseases can be triggered by viral infections. Several possible mechanisms of interactions between a virus and immune system have been analysed, with a prevailing opinion being that the onset of autoimmunity can in many cases be attributed to \"molecular mimicry\", where linear peptide epitopes, processed from viral proteins, mimic normal host self proteins, thus leading to a cross-reaction of immune response against virus with host cells. In this paper we present a mathematical model for the dynamics of an immune response to a viral infectio"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1209.4487","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1209.4487","created_at":"2026-05-18T03:45:11.569220+00:00"},{"alias_kind":"arxiv_version","alias_value":"1209.4487v1","created_at":"2026-05-18T03:45:11.569220+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1209.4487","created_at":"2026-05-18T03:45:11.569220+00:00"},{"alias_kind":"pith_short_12","alias_value":"Z7TG46V3SVMO","created_at":"2026-05-18T12:27:30.460161+00:00"},{"alias_kind":"pith_short_16","alias_value":"Z7TG46V3SVMOKL5U","created_at":"2026-05-18T12:27:30.460161+00:00"},{"alias_kind":"pith_short_8","alias_value":"Z7TG46V3","created_at":"2026-05-18T12:27:30.460161+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/Z7TG46V3SVMOKL5U2N5BNMAWY7","json":"https://pith.science/pith/Z7TG46V3SVMOKL5U2N5BNMAWY7.json","graph_json":"https://pith.science/api/pith-number/Z7TG46V3SVMOKL5U2N5BNMAWY7/graph.json","events_json":"https://pith.science/api/pith-number/Z7TG46V3SVMOKL5U2N5BNMAWY7/events.json","paper":"https://pith.science/paper/Z7TG46V3"},"agent_actions":{"view_html":"https://pith.science/pith/Z7TG46V3SVMOKL5U2N5BNMAWY7","download_json":"https://pith.science/pith/Z7TG46V3SVMOKL5U2N5BNMAWY7.json","view_paper":"https://pith.science/paper/Z7TG46V3","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1209.4487&json=true","fetch_graph":"https://pith.science/api/pith-number/Z7TG46V3SVMOKL5U2N5BNMAWY7/graph.json","fetch_events":"https://pith.science/api/pith-number/Z7TG46V3SVMOKL5U2N5BNMAWY7/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/Z7TG46V3SVMOKL5U2N5BNMAWY7/action/timestamp_anchor","attest_storage":"https://pith.science/pith/Z7TG46V3SVMOKL5U2N5BNMAWY7/action/storage_attestation","attest_author":"https://pith.science/pith/Z7TG46V3SVMOKL5U2N5BNMAWY7/action/author_attestation","sign_citation":"https://pith.science/pith/Z7TG46V3SVMOKL5U2N5BNMAWY7/action/citation_signature","submit_replication":"https://pith.science/pith/Z7TG46V3SVMOKL5U2N5BNMAWY7/action/replication_record"}},"created_at":"2026-05-18T03:45:11.569220+00:00","updated_at":"2026-05-18T03:45:11.569220+00:00"}