{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:Z7X56ZXWO6YTDT4JHJXAF6K3BC","short_pith_number":"pith:Z7X56ZXW","canonical_record":{"source":{"id":"2506.03406","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2025-06-03T21:29:41Z","cross_cats_sorted":[],"title_canon_sha256":"f80ff3e8a969848a4c8d6b67b9899e1abe0e5934d73961934630c6aee15a05d2","abstract_canon_sha256":"276c3c8c12595c2d8f0e6850e0e00ab712fe7af95c0c0421f39d81d3138dce57"},"schema_version":"1.0"},"canonical_sha256":"cfefdf66f677b131cf893a6e02f95b08827d7109f5119a26ca848e3cf701e3d0","source":{"kind":"arxiv","id":"2506.03406","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.03406","created_at":"2026-07-05T11:15:27Z"},{"alias_kind":"arxiv_version","alias_value":"2506.03406v1","created_at":"2026-07-05T11:15:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.03406","created_at":"2026-07-05T11:15:27Z"},{"alias_kind":"pith_short_12","alias_value":"Z7X56ZXWO6YT","created_at":"2026-07-05T11:15:27Z"},{"alias_kind":"pith_short_16","alias_value":"Z7X56ZXWO6YTDT4J","created_at":"2026-07-05T11:15:27Z"},{"alias_kind":"pith_short_8","alias_value":"Z7X56ZXW","created_at":"2026-07-05T11:15:27Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:Z7X56ZXWO6YTDT4JHJXAF6K3BC","target":"record","payload":{"canonical_record":{"source":{"id":"2506.03406","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2025-06-03T21:29:41Z","cross_cats_sorted":[],"title_canon_sha256":"f80ff3e8a969848a4c8d6b67b9899e1abe0e5934d73961934630c6aee15a05d2","abstract_canon_sha256":"276c3c8c12595c2d8f0e6850e0e00ab712fe7af95c0c0421f39d81d3138dce57"},"schema_version":"1.0"},"canonical_sha256":"cfefdf66f677b131cf893a6e02f95b08827d7109f5119a26ca848e3cf701e3d0","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:15:27.064241Z","signature_b64":"N0lf4oGGmkhOHpcvftovju5O8+pWFte8EEmKA4OjNy3cXRv9UPEESjzb+rC9p/Vh57d3PqvtD+dh+xoWUzX/Dg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"cfefdf66f677b131cf893a6e02f95b08827d7109f5119a26ca848e3cf701e3d0","last_reissued_at":"2026-07-05T11:15:27.063845Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:15:27.063845Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2506.03406","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:15:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"MVR4ztvnpOCR83iCMuo9qQEKGLxTHyO3AM6PD4rbn0vWPNaooUaiuSNzSMzh3MvteEq4/b9P5ZKyljGDeMDzBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-08T18:43:26.025809Z"},"content_sha256":"f1bae3ea5264e9f953d0ff6e400686cdaeef9f860f36032065f7c8cca5a61f6a","schema_version":"1.0","event_id":"sha256:f1bae3ea5264e9f953d0ff6e400686cdaeef9f860f36032065f7c8cca5a61f6a"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:Z7X56ZXWO6YTDT4JHJXAF6K3BC","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Online multi-layer FDR control","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Ran Dai, Runqiu Wang","submitted_at":"2025-06-03T21:29:41Z","abstract_excerpt":"When hypotheses are tested in a stream and real-time decision-making is needed, online sequential hypothesis testing procedures are needed. Furthermore, these hypotheses are commonly partitioned into groups by their nature. For example, the RNA nanocapsules can be partitioned based on therapeutic nucleic acids (siRNAs) being used, as well as the delivery nanocapsules. When selecting effective RNA nanocapsules, simultaneous false discovery rate control at multiple partition levels is needed. In this paper, we develop hypothesis testing procedures which controls false discovery rate (FDR) simult"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.03406","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2506.03406/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:15:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"OQcy6Ji1RXVzcdcfgwiN9MjARkBN2zWN+WdMZWB2Ko8ZiPdcwIVMXpuqa3XcFURuCyyUNlnMSyAQHrNeAH6yCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-08T18:43:26.026370Z"},"content_sha256":"8352353bba05ea7acbcd4c299e39a97b4e029f7f031195456e45460198c138f3","schema_version":"1.0","event_id":"sha256:8352353bba05ea7acbcd4c299e39a97b4e029f7f031195456e45460198c138f3"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/Z7X56ZXWO6YTDT4JHJXAF6K3BC/bundle.json","state_url":"https://pith.science/pith/Z7X56ZXWO6YTDT4JHJXAF6K3BC/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/Z7X56ZXWO6YTDT4JHJXAF6K3BC/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-08T18:43:26Z","links":{"resolver":"https://pith.science/pith/Z7X56ZXWO6YTDT4JHJXAF6K3BC","bundle":"https://pith.science/pith/Z7X56ZXWO6YTDT4JHJXAF6K3BC/bundle.json","state":"https://pith.science/pith/Z7X56ZXWO6YTDT4JHJXAF6K3BC/state.json","well_known_bundle":"https://pith.science/.well-known/pith/Z7X56ZXWO6YTDT4JHJXAF6K3BC/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:Z7X56ZXWO6YTDT4JHJXAF6K3BC","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"276c3c8c12595c2d8f0e6850e0e00ab712fe7af95c0c0421f39d81d3138dce57","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2025-06-03T21:29:41Z","title_canon_sha256":"f80ff3e8a969848a4c8d6b67b9899e1abe0e5934d73961934630c6aee15a05d2"},"schema_version":"1.0","source":{"id":"2506.03406","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.03406","created_at":"2026-07-05T11:15:27Z"},{"alias_kind":"arxiv_version","alias_value":"2506.03406v1","created_at":"2026-07-05T11:15:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.03406","created_at":"2026-07-05T11:15:27Z"},{"alias_kind":"pith_short_12","alias_value":"Z7X56ZXWO6YT","created_at":"2026-07-05T11:15:27Z"},{"alias_kind":"pith_short_16","alias_value":"Z7X56ZXWO6YTDT4J","created_at":"2026-07-05T11:15:27Z"},{"alias_kind":"pith_short_8","alias_value":"Z7X56ZXW","created_at":"2026-07-05T11:15:27Z"}],"graph_snapshots":[{"event_id":"sha256:8352353bba05ea7acbcd4c299e39a97b4e029f7f031195456e45460198c138f3","target":"graph","created_at":"2026-07-05T11:15:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2506.03406/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"When hypotheses are tested in a stream and real-time decision-making is needed, online sequential hypothesis testing procedures are needed. Furthermore, these hypotheses are commonly partitioned into groups by their nature. For example, the RNA nanocapsules can be partitioned based on therapeutic nucleic acids (siRNAs) being used, as well as the delivery nanocapsules. When selecting effective RNA nanocapsules, simultaneous false discovery rate control at multiple partition levels is needed. In this paper, we develop hypothesis testing procedures which controls false discovery rate (FDR) simult","authors_text":"Ran Dai, Runqiu Wang","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2025-06-03T21:29:41Z","title":"Online multi-layer FDR control"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.03406","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f1bae3ea5264e9f953d0ff6e400686cdaeef9f860f36032065f7c8cca5a61f6a","target":"record","created_at":"2026-07-05T11:15:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"276c3c8c12595c2d8f0e6850e0e00ab712fe7af95c0c0421f39d81d3138dce57","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2025-06-03T21:29:41Z","title_canon_sha256":"f80ff3e8a969848a4c8d6b67b9899e1abe0e5934d73961934630c6aee15a05d2"},"schema_version":"1.0","source":{"id":"2506.03406","kind":"arxiv","version":1}},"canonical_sha256":"cfefdf66f677b131cf893a6e02f95b08827d7109f5119a26ca848e3cf701e3d0","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"cfefdf66f677b131cf893a6e02f95b08827d7109f5119a26ca848e3cf701e3d0","first_computed_at":"2026-07-05T11:15:27.063845Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:15:27.063845Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"N0lf4oGGmkhOHpcvftovju5O8+pWFte8EEmKA4OjNy3cXRv9UPEESjzb+rC9p/Vh57d3PqvtD+dh+xoWUzX/Dg==","signature_status":"signed_v1","signed_at":"2026-07-05T11:15:27.064241Z","signed_message":"canonical_sha256_bytes"},"source_id":"2506.03406","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f1bae3ea5264e9f953d0ff6e400686cdaeef9f860f36032065f7c8cca5a61f6a","sha256:8352353bba05ea7acbcd4c299e39a97b4e029f7f031195456e45460198c138f3"],"state_sha256":"cdfdfc42bb09d314ef5f40a0db59848371cdf9a309b4c0f07f3030ab3b1ac51b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ANWYaJhDMm2tFcmiins9F+GML49O14Ih0hmVOAkvRaMxy5OhIeCSFS2gfyElCqWlFGHms0ELYh23v6f045y4Bw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-08T18:43:26.030401Z","bundle_sha256":"d2e46f14468262ecae13da48670ed5cdf0eab1747b789fa1491953bc5d5231df"}}